{"id":"9bd8b00d-8ae8-5e84-9253-1a27ff9a94ec","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-gemfibrozil-lactone-null","predicate":"does_not_change_significantly","statement":"Gemfibrozil did not significantly change parent lovastatin pharmacokinetic parameters in that LipoCol Forte experiment.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"218bd87c-735b-53e1-8251-86994df0387d","mechanism_event_label":"The lactone and acid did not show the same interaction result.","subject":{"id":"be172818-3b91-5a27-8657-a620397442da","slug":"gemfibrozil","display_name":"Gemfibrozil","entity_type_key":"drug"},"object":{"id":"d4154949-85ce-5c98-9f32-af94e72d613a","slug":"human-lovastatin-plasma-exposure","display_name":"Human plasma exposure to lovastatin","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"218bd87c-735b-53e1-8251-86994df0387d","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-gemfibrozil-lactone-null-event","event_type":"observed_relationship","label":"The lactone and acid did not show the same interaction result.","description":"Gemfibrozil did not significantly change parent lovastatin pharmacokinetic parameters in that LipoCol Forte experiment.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"be172818-3b91-5a27-8657-a620397442da","slug":"gemfibrozil","display_name":"Gemfibrozil","entity_type_key":"drug"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d4154949-85ce-5c98-9f32-af94e72d613a","slug":"human-lovastatin-plasma-exposure","display_name":"Human plasma exposure to lovastatin","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"30978ef1-162a-52bd-bb88-2e506565f5bc","slug":"lipocol-forte-2012","display_name":"LipoCol Forte red yeast rice preparation studied in 2012","entity_type_key":"drug"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"5d0ea9bb-cce8-5e13-aa3d-37db2215386e","slug":"lovastatin","display_name":"Lovastatin / monacolin K lactone","entity_type_key":"drug"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text PMC3513969","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Same 13 volunteers and dosing protocol.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The positive acid result must not be generalized to every measured chemical form.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Red yeast rice collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"red-yeast-rice","display_name":"Red yeast rice","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"The lactone and acid did not show the same interaction result.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[23227093] Interaction between Red Yeast Rice and CYP450 Enzymes/P-Glycoprotein and Its Implication for the Clinical Pharmacokinetics of Lovastatin. · 2012 · https://pubmed.ncbi.nlm.nih.gov/23227093/ · DOI 10.1155/2012/127043","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"0b31e515-9c92-5e0f-bd3d-86bd29ad9b4e","evidence_kind":"source_excerpt","locator":"Lines 172-178","start_line":172,"end_line":178,"excerpt":"## red-yeast-rice-gemfibrozil-lactone-null\nThe lactone and acid did not show the same interaction result.\nGemfibrozil did not significantly change parent lovastatin pharmacokinetic parameters in that LipoCol Forte experiment.\nModel: Same 13 volunteers and dosing protocol.\nLimitations: The positive acid result must not be generalized to every measured chemical form.\nEvidence access: Primary full text PMC3513969\n[23227093] Interaction between Red Yeast Rice and CYP450 Enzymes/P-Glycoprotein and Its Implication for the Clinical Pharmacokinetics of Lovastatin. · 2012 · https://pubmed.ncbi.nlm.nih.gov/23227093/ · DOI 10.1155/2012/127043","model_system":"Same 13 volunteers and dosing protocol.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"261a12bc-3d00-52a4-a5ec-70e174390596","stable_key":"import-4910e17b-aaec-52cd-b9e5-caca85d817ee","title":"Red yeast rice: constituents, mevalonate, CoQ and product-specific interactions (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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