Component

Green tea extract, study-specific mixture

Study-scoped entity; inspect species, exposure, model and limitations on each claim.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. In 39 women studied for 30 days, folate stayed in the normal range across EGCG-containing-extract groups, including groups receiving clomiphene or letrozole.

    Green tea extract, study-specific mixture → Serum folate concentration source_derived_draftungraded
    Experimental context and source evidence
    experimental_model
    Women aged 18–40; all groups received extract; selected MTHFR and DHFR genotypes considered.
    limitations
    No extract-free control, pregnancy outcome or long-term depletion test. Abstract dose terminology is inconsistent; no pure-EGCG dose is inferred.
    nutrient_topic
    EGCG collection; comparator and shared-pathway records retain their actual intervention. · Epigallocatechin-3-gallate (EGCG)
    plain_language
    This short human study did not reproduce folate depletion.
    primary_references
    Evaluating the Effect of Epigallocatechin Gallate (EGCG) in Reducing Folate Levels in Reproductive Aged Women by MTHFR and DHFR Genotype in Combination With Letrozole or Clomiphene. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40077973/ · DOI 10.1111/cts.70189

    EGCG: receptor signaling, metabolism, nutrient interactions and discovery questions (2026-09-18) · lines 156–162

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Women aged 18–40; all groups received extract; selected MTHFR and DHFR genotypes considered. · source_derived_draft · unverified_draft

    ## egcg-human-folate This short human study did not reproduce folate depletion. In 39 women studied for 30 days, folate stayed in the normal range across EGCG-containing-extract groups, including groups receiving clomiphene or letrozole. Model: Women aged 18–40; all groups received extract; selected MTHFR and DHFR genotypes considered. Limitations: No extract-free control, pregnancy outcome or long-term depletion test. Abstract dose terminology is inconsistent; no pure-EGCG dose is inferred. Evidence access: primary abstract. Evaluating the Effect of Epigallocatechin Gallate (EGCG) in Reducing Folate Levels in Reproductive Aged Women by MTHFR and DHFR Genotype in Combination With Letrozole or Clomiphene. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40077973/ · DOI 10.1111/cts.70189
    Complete structured claim and evidence

  2. In the 12-month randomized trial, 26/513 extract recipients (5.1%) developed moderate-or-greater liver-test abnormalities; odds ratio versus placebo was 7.0 (95% CI 2.4–20.3).

    Green tea extract, study-specific mixture → Serum liver-enzyme elevations source_derived_draftungraded
    Experimental context and source evidence
    experimental_model
    1021 analyzed women with normal baseline enzymes; 513 extract and 508 placebo.
    limitations
    An extract trial does not isolate EGCG as the sole causal constituent or estimate risk from ordinary tea drinking.
    nutrient_topic
    EGCG collection; comparator and shared-pathway records retain their actual intervention. · Epigallocatechin-3-gallate (EGCG)
    plain_language
    Concentrated extract increased liver-test abnormalities in this trial.
    primary_references
    Effect of Green Tea Supplements on Liver Enzyme Elevation: Results from a Randomized Intervention Study in the United States. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28765194/ · DOI 10.1158/1940-6207.capr-17-0160

    EGCG: receptor signaling, metabolism, nutrient interactions and discovery questions (2026-09-18) · lines 540–546

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · 1021 analyzed women with normal baseline enzymes; 513 extract and 508 placebo. · source_derived_draft · unverified_draft

    ## egcg-liver-rct Concentrated extract increased liver-test abnormalities in this trial. In the 12-month randomized trial, 26/513 extract recipients (5.1%) developed moderate-or-greater liver-test abnormalities; odds ratio versus placebo was 7.0 (95% CI 2.4–20.3). Model: 1021 analyzed women with normal baseline enzymes; 513 extract and 508 placebo. Limitations: An extract trial does not isolate EGCG as the sole causal constituent or estimate risk from ordinary tea drinking. Evidence access: primary abstract. Effect of Green Tea Supplements on Liver Enzyme Elevation: Results from a Randomized Intervention Study in the United States. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28765194/ · DOI 10.1158/1940-6207.capr-17-0160
    Complete structured claim and evidence

  3. ALT decreased after stopping extract and increased after rechallenge in affected participants.

    Green tea extract, study-specific mixture → Serum liver-enzyme elevations source_derived_draftungraded
    Experimental context and source evidence
    experimental_model
    Trial dechallenge/rechallenge observations.
    limitations
    These observations do not establish a single molecular injury pathway.
    nutrient_topic
    EGCG collection; comparator and shared-pathway records retain their actual intervention. · Epigallocatechin-3-gallate (EGCG)
    plain_language
    Stopping and restarting strengthened the link to the extract.
    primary_references
    Effect of Green Tea Supplements on Liver Enzyme Elevation: Results from a Randomized Intervention Study in the United States. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28765194/ · DOI 10.1158/1940-6207.capr-17-0160

    EGCG: receptor signaling, metabolism, nutrient interactions and discovery questions (2026-09-18) · lines 548–554

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Trial dechallenge/rechallenge observations. · source_derived_draft · unverified_draft

    ## egcg-liver-rechallenge Stopping and restarting strengthened the link to the extract. ALT decreased after stopping extract and increased after rechallenge in affected participants. Model: Trial dechallenge/rechallenge observations. Limitations: These observations do not establish a single molecular injury pathway. Evidence access: primary abstract. Effect of Green Tea Supplements on Liver Enzyme Elevation: Results from a Randomized Intervention Study in the United States. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28765194/ · DOI 10.1158/1940-6207.capr-17-0160
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. HLA-B*35:01 was present in 72% of 40 adjudicated green-tea liver-injury cases, versus 11% in population controls.

    Human HLA-B*35:01 allele → Green-tea-associated liver injury source_derived_draftungraded
    Experimental context and source evidence
    experimental_model
    Drug-Induced Liver Injury Network selected case series; 95% hepatocellular, 35% severe, three transplants.
    limitations
    Selected cases are not an incidence estimate; association does not prove antigen presentation or deterministic injury in carriers.
    nutrient_topic
    EGCG collection; comparator and shared-pathway records retain their actual intervention. · Epigallocatechin-3-gallate (EGCG)
    plain_language
    A genetic association suggests an immune contribution to some liver injuries.
    primary_references
    HLA-B*35:01 and Green Tea-Induced Liver Injury. · 2021 · https://pubmed.ncbi.nlm.nih.gov/32892374/ · DOI 10.1002/hep.31538

    EGCG: receptor signaling, metabolism, nutrient interactions and discovery questions (2026-09-18) · lines 556–562

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Drug-Induced Liver Injury Network selected case series; 95% hepatocellular, 35% severe, three transplants. · source_derived_draft · unverified_draft

    ## egcg-hla A genetic association suggests an immune contribution to some liver injuries. HLA-B*35:01 was present in 72% of 40 adjudicated green-tea liver-injury cases, versus 11% in population controls. Model: Drug-Induced Liver Injury Network selected case series; 95% hepatocellular, 35% severe, three transplants. Limitations: Selected cases are not an incidence estimate; association does not prove antigen presentation or deterministic injury in carriers. Evidence access: primary abstract. HLA-B*35:01 and Green Tea-Induced Liver Injury. · 2021 · https://pubmed.ncbi.nlm.nih.gov/32892374/ · DOI 10.1002/hep.31538
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards