Component
Human HLA-B*35:01 allele
Study-scoped entity; inspect species, exposure, model and limitations on each claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
HLA-B*35:01 was present in 72% of 40 adjudicated green-tea liver-injury cases, versus 11% in population controls.
Experimental context and source evidence
- experimental_model
- Drug-Induced Liver Injury Network selected case series; 95% hepatocellular, 35% severe, three transplants.
- limitations
- Selected cases are not an incidence estimate; association does not prove antigen presentation or deterministic injury in carriers.
- nutrient_topic
- EGCG collection; comparator and shared-pathway records retain their actual intervention. · Epigallocatechin-3-gallate (EGCG)
- plain_language
- A genetic association suggests an immune contribution to some liver injuries.
- primary_references
- HLA-B*35:01 and Green Tea-Induced Liver Injury. · 2021 · https://pubmed.ncbi.nlm.nih.gov/32892374/ · DOI 10.1002/hep.31538
EGCG: receptor signaling, metabolism, nutrient interactions and discovery questions (2026-09-18) · lines 556–562
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Drug-Induced Liver Injury Network selected case series; 95% hepatocellular, 35% severe, three transplants. · source_derived_draft · unverified_draft
## egcg-hla A genetic association suggests an immune contribution to some liver injuries. HLA-B*35:01 was present in 72% of 40 adjudicated green-tea liver-injury cases, versus 11% in population controls. Model: Drug-Induced Liver Injury Network selected case series; 95% hepatocellular, 35% severe, three transplants. Limitations: Selected cases are not an incidence estimate; association does not prove antigen presentation or deterministic injury in carriers. Evidence access: primary abstract. HLA-B*35:01 and Green Tea-Induced Liver Injury. · 2021 · https://pubmed.ncbi.nlm.nih.gov/32892374/ · DOI 10.1002/hep.31538
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.