{"id":"3a076017-6dd8-5f28-8bc9-e5606dfc9a26","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-hla","predicate":"associated_with","statement":"HLA-B*35:01 was present in 72% of 40 adjudicated green-tea liver-injury cases, versus 11% in population controls.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"e89b896f-022f-5ffe-941e-de0ae4f36a4f","mechanism_event_label":"A genetic association suggests an immune contribution to some liver injuries.","subject":{"id":"4d7cc610-1a3b-5b54-982b-dcbff1b5b982","slug":"hla-b-35-01","display_name":"Human HLA-B*35:01 allele","entity_type_key":"gene"},"object":{"id":"23074e25-6eea-5d93-a59e-57445406ffb3","slug":"green-tea-associated-liver-injury","display_name":"Green-tea-associated liver injury","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"e89b896f-022f-5ffe-941e-de0ae4f36a4f","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-hla-event","event_type":"observed_relationship","label":"A genetic association suggests an immune contribution to some liver injuries.","description":"HLA-B*35:01 was present in 72% of 40 adjudicated green-tea liver-injury cases, versus 11% in population controls.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4d7cc610-1a3b-5b54-982b-dcbff1b5b982","slug":"hla-b-35-01","display_name":"Human HLA-B*35:01 allele","entity_type_key":"gene"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"23074e25-6eea-5d93-a59e-57445406ffb3","slug":"green-tea-associated-liver-injury","display_name":"Green-tea-associated liver injury","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"58cbd901-c851-5c3c-bc65-116da20b91c5","slug":"green-tea-extract","display_name":"Green tea extract, study-specific mixture","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Drug-Induced Liver Injury Network selected case series; 95% hepatocellular, 35% severe, three transplants.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Selected cases are not an incidence estimate; association does not prove antigen presentation or deterministic injury in carriers.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"EGCG collection; comparator and shared-pathway records retain their actual intervention.","comparator":null,"unit":null,"notes":"","entity":{"slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A genetic association suggests an immune contribution to some liver injuries.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"HLA-B*35:01 and Green Tea-Induced Liver Injury. · 2021 · https://pubmed.ncbi.nlm.nih.gov/32892374/ · DOI 10.1002/hep.31538","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"2fc74aba-86af-5ef4-b74f-ea3835297f0c","evidence_kind":"source_excerpt","locator":"Lines 556-562","start_line":556,"end_line":562,"excerpt":"## egcg-hla\nA genetic association suggests an immune contribution to some liver injuries.\nHLA-B*35:01 was present in 72% of 40 adjudicated green-tea liver-injury cases, versus 11% in population controls.\nModel: Drug-Induced Liver Injury Network selected case series; 95% hepatocellular, 35% severe, three transplants.\nLimitations: Selected cases are not an incidence estimate; association does not prove antigen presentation or deterministic injury in carriers.\nEvidence access: primary abstract.\nHLA-B*35:01 and Green Tea-Induced Liver Injury. · 2021 · https://pubmed.ncbi.nlm.nih.gov/32892374/ · DOI 10.1002/hep.31538","model_system":"Drug-Induced Liver Injury Network selected case series; 95% hepatocellular, 35% severe, three transplants.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Primary-abstract paraphrase; no full-text methods verification claimed.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1f6d09e8-3aae-5c41-9ea7-15d0d1cab72d","stable_key":"import-ec987f3e-0b3c-55cc-b304-c703a738e35d","title":"EGCG: receptor signaling, metabolism, nutrient interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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