Component
Serum liver-enzyme elevations
Study-scoped entity; inspect species, exposure, model and limitations on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
In the 12-month randomized trial, 26/513 extract recipients (5.1%) developed moderate-or-greater liver-test abnormalities; odds ratio versus placebo was 7.0 (95% CI 2.4–20.3).
Experimental context and source evidence
- experimental_model
- 1021 analyzed women with normal baseline enzymes; 513 extract and 508 placebo.
- limitations
- An extract trial does not isolate EGCG as the sole causal constituent or estimate risk from ordinary tea drinking.
- nutrient_topic
- EGCG collection; comparator and shared-pathway records retain their actual intervention. · Epigallocatechin-3-gallate (EGCG)
- plain_language
- Concentrated extract increased liver-test abnormalities in this trial.
- primary_references
- Effect of Green Tea Supplements on Liver Enzyme Elevation: Results from a Randomized Intervention Study in the United States. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28765194/ · DOI 10.1158/1940-6207.capr-17-0160
EGCG: receptor signaling, metabolism, nutrient interactions and discovery questions (2026-09-18) · lines 540–546
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · 1021 analyzed women with normal baseline enzymes; 513 extract and 508 placebo. · source_derived_draft · unverified_draft
## egcg-liver-rct Concentrated extract increased liver-test abnormalities in this trial. In the 12-month randomized trial, 26/513 extract recipients (5.1%) developed moderate-or-greater liver-test abnormalities; odds ratio versus placebo was 7.0 (95% CI 2.4–20.3). Model: 1021 analyzed women with normal baseline enzymes; 513 extract and 508 placebo. Limitations: An extract trial does not isolate EGCG as the sole causal constituent or estimate risk from ordinary tea drinking. Evidence access: primary abstract. Effect of Green Tea Supplements on Liver Enzyme Elevation: Results from a Randomized Intervention Study in the United States. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28765194/ · DOI 10.1158/1940-6207.capr-17-0160
Complete structured claim and evidenceALT decreased after stopping extract and increased after rechallenge in affected participants.
Experimental context and source evidence
- experimental_model
- Trial dechallenge/rechallenge observations.
- limitations
- These observations do not establish a single molecular injury pathway.
- nutrient_topic
- EGCG collection; comparator and shared-pathway records retain their actual intervention. · Epigallocatechin-3-gallate (EGCG)
- plain_language
- Stopping and restarting strengthened the link to the extract.
- primary_references
- Effect of Green Tea Supplements on Liver Enzyme Elevation: Results from a Randomized Intervention Study in the United States. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28765194/ · DOI 10.1158/1940-6207.capr-17-0160
EGCG: receptor signaling, metabolism, nutrient interactions and discovery questions (2026-09-18) · lines 548–554
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Trial dechallenge/rechallenge observations. · source_derived_draft · unverified_draft
## egcg-liver-rechallenge Stopping and restarting strengthened the link to the extract. ALT decreased after stopping extract and increased after rechallenge in affected participants. Model: Trial dechallenge/rechallenge observations. Limitations: These observations do not establish a single molecular injury pathway. Evidence access: primary abstract. Effect of Green Tea Supplements on Liver Enzyme Elevation: Results from a Randomized Intervention Study in the United States. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28765194/ · DOI 10.1158/1940-6207.capr-17-0160
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.