{"id":"eb4066e1-daf3-54d1-bea6-609ef051a100","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-liver-rechallenge","predicate":"associated_with","statement":"ALT decreased after stopping extract and increased after rechallenge in affected participants.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"842f7021-095f-575e-8192-b8573a9c3728","mechanism_event_label":"Stopping and restarting strengthened the link to the extract.","subject":{"id":"58cbd901-c851-5c3c-bc65-116da20b91c5","slug":"green-tea-extract","display_name":"Green tea extract, study-specific mixture","entity_type_key":"chemical_species"},"object":{"id":"5b0b2369-77e9-5071-87fa-aca305d37767","slug":"liver-enzyme-elevation","display_name":"Serum liver-enzyme elevations","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"842f7021-095f-575e-8192-b8573a9c3728","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-liver-rechallenge-event","event_type":"observed_relationship","label":"Stopping and restarting strengthened the link to the extract.","description":"ALT decreased after stopping extract and increased after rechallenge in affected participants.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"58cbd901-c851-5c3c-bc65-116da20b91c5","slug":"green-tea-extract","display_name":"Green tea extract, study-specific mixture","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5b0b2369-77e9-5071-87fa-aca305d37767","slug":"liver-enzyme-elevation","display_name":"Serum liver-enzyme elevations","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Trial dechallenge/rechallenge observations.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"These observations do not establish a single molecular injury pathway.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"EGCG collection; comparator and shared-pathway records retain their actual intervention.","comparator":null,"unit":null,"notes":"","entity":{"slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Stopping and restarting strengthened the link to the extract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Effect of Green Tea Supplements on Liver Enzyme Elevation: Results from a Randomized Intervention Study in the United States. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28765194/ · DOI 10.1158/1940-6207.capr-17-0160","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"84e5e1df-4a53-5575-8649-056af2795ce4","evidence_kind":"source_excerpt","locator":"Lines 548-554","start_line":548,"end_line":554,"excerpt":"## egcg-liver-rechallenge\nStopping and restarting strengthened the link to the extract.\nALT decreased after stopping extract and increased after rechallenge in affected participants.\nModel: Trial dechallenge/rechallenge observations.\nLimitations: These observations do not establish a single molecular injury pathway.\nEvidence access: primary abstract.\nEffect of Green Tea Supplements on Liver Enzyme Elevation: Results from a Randomized Intervention Study in the United States. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28765194/ · DOI 10.1158/1940-6207.capr-17-0160","model_system":"Trial dechallenge/rechallenge observations.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Primary-abstract paraphrase; no full-text methods verification claimed.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1f6d09e8-3aae-5c41-9ea7-15d0d1cab72d","stable_key":"import-ec987f3e-0b3c-55cc-b304-c703a738e35d","title":"EGCG: receptor signaling, metabolism, nutrient interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"b101c8d4d96ee03ff97eb1922c7bb0f96943295af473fdc3ef98b0dbd62fe8c7","revision_id":"e19bc5b2-ee3c-5f67-b5c5-9dc3b7d5f850","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}