{"id":"e43e00d4-b7e4-538f-bc03-2e4f0b370782","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-human-folate","predicate":"no_observed_depletion","statement":"In 39 women studied for 30 days, folate stayed in the normal range across EGCG-containing-extract groups, including groups receiving clomiphene or letrozole.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"54a052b3-3192-5bc0-9020-a70bd6555a91","mechanism_event_label":"This short human study did not reproduce folate depletion.","subject":{"id":"58cbd901-c851-5c3c-bc65-116da20b91c5","slug":"green-tea-extract","display_name":"Green tea extract, study-specific mixture","entity_type_key":"chemical_species"},"object":{"id":"69fa9bd2-2d5e-5468-b810-496ee7effcfc","slug":"serum-folate-concentration","display_name":"Serum folate concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"54a052b3-3192-5bc0-9020-a70bd6555a91","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-human-folate-event","event_type":"observed_relationship","label":"This short human study did not reproduce folate depletion.","description":"In 39 women studied for 30 days, folate stayed in the normal range across EGCG-containing-extract groups, including groups receiving clomiphene or letrozole.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"58cbd901-c851-5c3c-bc65-116da20b91c5","slug":"green-tea-extract","display_name":"Green tea extract, study-specific mixture","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"69fa9bd2-2d5e-5468-b810-496ee7effcfc","slug":"serum-folate-concentration","display_name":"Serum folate concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e176a266-711e-5469-89da-3fb2d3f244ad","slug":"folate","display_name":"Folate (vitamin B9)","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"22e1b8eb-f35f-5afa-be20-b0534df9f6be","slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Women aged 18–40; all groups received extract; selected MTHFR and DHFR genotypes considered.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No extract-free control, pregnancy outcome or long-term depletion test. Abstract dose terminology is inconsistent; no pure-EGCG dose is inferred.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"EGCG collection; comparator and shared-pathway records retain their actual intervention.","comparator":null,"unit":null,"notes":"","entity":{"slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"This short human study did not reproduce folate depletion.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Evaluating the Effect of Epigallocatechin Gallate (EGCG) in Reducing Folate Levels in Reproductive Aged Women by MTHFR and DHFR Genotype in Combination With Letrozole or Clomiphene. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40077973/ · DOI 10.1111/cts.70189","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"1fe9c160-421f-56ea-8354-f5a50008ecdb","evidence_kind":"source_excerpt","locator":"Lines 156-162","start_line":156,"end_line":162,"excerpt":"## egcg-human-folate\nThis short human study did not reproduce folate depletion.\nIn 39 women studied for 30 days, folate stayed in the normal range across EGCG-containing-extract groups, including groups receiving clomiphene or letrozole.\nModel: Women aged 18–40; all groups received extract; selected MTHFR and DHFR genotypes considered.\nLimitations: No extract-free control, pregnancy outcome or long-term depletion test. Abstract dose terminology is inconsistent; no pure-EGCG dose is inferred.\nEvidence access: primary abstract.\nEvaluating the Effect of Epigallocatechin Gallate (EGCG) in Reducing Folate Levels in Reproductive Aged Women by MTHFR and DHFR Genotype in Combination With Letrozole or Clomiphene. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40077973/ · DOI 10.1111/cts.70189","model_system":"Women aged 18–40; all groups received extract; selected MTHFR and DHFR genotypes considered.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Primary-abstract paraphrase; no full-text methods verification claimed.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1f6d09e8-3aae-5c41-9ea7-15d0d1cab72d","stable_key":"import-ec987f3e-0b3c-55cc-b304-c703a738e35d","title":"EGCG: receptor signaling, metabolism, nutrient interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"b101c8d4d96ee03ff97eb1922c7bb0f96943295af473fdc3ef98b0dbd62fe8c7","revision_id":"e19bc5b2-ee3c-5f67-b5c5-9dc3b7d5f850","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}