Component

Urinary oxalate excretion

Process or measured study endpoint, not a chemical species; outcome definition is retained in claim context.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Urinary oxalate rose with the low-calcium diet but fell with the normal-calcium, lower-protein, lower-salt diet.

    Calcium → Urinary oxalate excretion source_derived_draftungraded
    Experimental context and source evidence
    experimental_model
    Same randomized dietary trial.
    limitations
    Urine result supports a plausible intestinal explanation but does not isolate binding or prove mediation of recurrence.
    nutrient_topic
    Calcium research collection; topical membership is not evidence of a direct dietary effect. · Calcium
    organism
    Homo sapiens
    plain_language
    Diet composition changed urinary oxalate as well as calcium.
    primary_references
    [cal-clin-borghi2002] Comparison of two diets for the prevention of recurrent stones in idiopathic hypercalciuria (2002). https://pubmed.ncbi.nlm.nih.gov/11784873/ DOI: 10.1056/NEJMoa010369
    tissue_or_cell_type
    Human clinical or absorption endpoint

    Calcium: mechanism-first literature curation (2026-09-17) · lines 1247–1256

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Same randomized dietary trial. · source_derived_draft · unverified_draft

    ### cal-borghi-urinary-oxalate Urinary oxalate rose with the low-calcium diet but fell with the normal-calcium, lower-protein, lower-salt diet. Condition category: normal nutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect. plain_language: Diet composition changed urinary oxalate as well as calcium. organism: Homo sapiens tissue_or_cell_type: Human clinical or absorption endpoint experimental_model: Same randomized dietary trial. limitations: Urine result supports a plausible intestinal explanation but does not isolate binding or prove mediation of recurrence. [cal-clin-borghi2002] Comparison of two diets for the prevention of recurrent stones in idiopathic hypercalciuria (2002). https://pubmed.ncbi.nlm.nih.gov/11784873/ DOI: 10.1056/NEJMoa010369
    Complete structured claim and evidence

  2. Calcium carbonate with meals lowered urinary oxalate from baseline; bedtime dosing did not.

    Calcium carbonate → Urinary oxalate excretion source_derived_draftungraded
    Experimental context and source evidence
    experimental_model
    32 healthy men, one-week crossover regimens.
    exposure
    1 g calcium carbonate with each of three meals versus 3 g carbonate at bedtime: compound mass, not 3 g elemental calcium.
    limitations
    This experiment measured urine, not long-term stone incidence.
    nutrient_topic
    Calcium research collection; topical membership is not evidence of a direct dietary effect. · Calcium
    organism
    Homo sapiens
    plain_language
    Taking the tested preparation with food changed oxalate handling.
    primary_references
    [cal-clin-domrong2004] Schedule of taking calcium supplement and the risk of nephrolithiasis (2004). https://pubmed.ncbi.nlm.nih.gov/15086924/ DOI: 10.1111/j.1523-1755.2004.00587.x
    tissue_or_cell_type
    Human clinical or absorption endpoint

    Calcium: mechanism-first literature curation (2026-09-17) · lines 1258–1268

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · 32 healthy men, one-week crossover regimens. · source_derived_draft · unverified_draft

    ### cal-meal-urinary-oxalate Calcium carbonate with meals lowered urinary oxalate from baseline; bedtime dosing did not. Condition category: normal nutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect. plain_language: Taking the tested preparation with food changed oxalate handling. organism: Homo sapiens tissue_or_cell_type: Human clinical or absorption endpoint experimental_model: 32 healthy men, one-week crossover regimens. limitations: This experiment measured urine, not long-term stone incidence. exposure: 1 g calcium carbonate with each of three meals versus 3 g carbonate at bedtime: compound mass, not 3 g elemental calcium. [cal-clin-domrong2004] Schedule of taking calcium supplement and the risk of nephrolithiasis (2004). https://pubmed.ncbi.nlm.nih.gov/15086924/ DOI: 10.1111/j.1523-1755.2004.00587.x
    Complete structured claim and evidence

  3. Boron supplementation decreased total urinary oxalate in the low-magnesium group.

    Boron → Urinary oxalate excretion source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/boron-research/9062533.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a23cd1fe09277bdd83b690746d4bbaf4742cdd74e51d5b27ee898bd87208b2be", "start_char": 0, "end_char": 1720, "text_sha256": "a23cd1fe09277bdd83b690746d4bbaf4742cdd74e51d5b27ee898bd87208b2be"}
    experimental_model
    Metabolic-ward feeding; 11 postmenopausal volunteers
    exposure
    167-day study; basal 0.36 mg B and 109 mg Mg/8400 kJ; 3 mg/day B supplement in last two 24-day periods; magnesium supplement 0 or 200 mg/day
    limitations
    Small study with multiple dietary periods and supplements. Do not assume independence from related reports from the same research program. Urine composition is not a kidney-stone clinical endpoint.
    nutrient_topic
    Boron research collection; topical membership is not evidence of a direct dietary effect. · Boron
    organism
    Human
    plain_language
    Less oxalate appeared in urine in this setting; fewer kidney stones were not demonstrated.
    primary_references
    [boron-p9062533] Metabolic responses of postmenopausal women to supplemental dietary boron and aluminum during usual and low magnesium intake: boron, calcium, and magnesium absorption and retention and blood mineral concentrations. (1997). https://pubmed.ncbi.nlm.nih.gov/9062533/ DOI: 10.1093/ajcn/65.3.803
    tissue_or_cell_type
    Mineral balance, blood and excreta
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Boron: chemistry, nutrient interactions, low-intake studies and mechanistic uncertainties (2026-09-17) · lines 677–688

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Metabolic-ward feeding; 11 postmenopausal volunteers · source_derived_draft · unverified_draft

    ### boron-oxalate-low-magnesium Boron supplementation decreased total urinary oxalate in the low-magnesium group. Condition category: nutrient_deficiency nutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect. plain_language: Less oxalate appeared in urine in this setting; fewer kidney stones were not demonstrated. organism: Human tissue_or_cell_type: Mineral balance, blood and excreta experimental_model: Metabolic-ward feeding; 11 postmenopausal volunteers limitations: Small study with multiple dietary periods and supplements. Do not assume independence from related reports from the same research program. Urine composition is not a kidney-stone clinical endpoint. exposure: 167-day study; basal 0.36 mg B and 109 mg Mg/8400 kJ; 3 mg/day B supplement in last two 24-day periods; magnesium supplement 0 or 200 mg/day evidence_span: {"source_cache": "artifacts/boron-research/9062533.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a23cd1fe09277bdd83b690746d4bbaf4742cdd74e51d5b27ee898bd87208b2be", "start_char": 0, "end_char": 1720, "text_sha256": "a23cd1fe09277bdd83b690746d4bbaf4742cdd74e51d5b27ee898bd87208b2be"} [boron-p9062533] Metabolic responses of postmenopausal women to supplemental dietary boron and aluminum during usual and low magnesium intake: boron, calcium, and magnesium absorption and retention and blood mineral concentrations. (1997). https://pubmed.ncbi.nlm.nih.gov/9062533/ DOI: 10.1093/ajcn/65.3.803
    Complete structured claim and evidence

  4. Nineteen of 48 participants, including 12 stone formers and seven non-stone formers, had more than 10% greater 24-hour oxalate excretion with 2 g/day vitamin C.

    L-Ascorbic acid → Urinary oxalate excretion source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    Oxalate is relevant to calcium oxalate stone chemistry.
    experimental_model
    Randomized controlled-diet crossover study: 29 calcium stone formers and 19 non-stone formers.
    exposure
    Ascorbic acid 1000 mg twice daily for six days versus no supplement for six days; 13C2 oxalate challenge after adaptation.
    limitations
    Responders were defined by the observed rise; no incident-stone endpoint and no extrapolation to ordinary food intake.
    nutrient_topic
    Vitamin C research collection; topical membership is not evidence of a direct dietary effect. · Vitamin C
    organism
    Homo sapiens
    plain_language
    Some people excreted more oxalate after the high oral exposure.
    primary_references
    [c-massey2005] Ascorbate increases human oxaluria and kidney stone risk (2005). https://pubmed.ncbi.nlm.nih.gov/15987848/ DOI: 10.1093/jn/135.7.1673
    tissue_or_cell_type
    Human blood or whole-person endpoints

    Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1645–1656

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized controlled-diet crossover study: 29 calcium stone formers and 19 non-stone formers. · source_derived_draft · unverified_draft

    ### c-high-oral-dose-oxaluria Nineteen of 48 participants, including 12 stone formers and seven non-stone formers, had more than 10% greater 24-hour oxalate excretion with 2 g/day vitamin C. Condition category: normal nutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect. plain_language: Some people excreted more oxalate after the high oral exposure. organism: Homo sapiens tissue_or_cell_type: Human blood or whole-person endpoints experimental_model: Randomized controlled-diet crossover study: 29 calcium stone formers and 19 non-stone formers. limitations: Responders were defined by the observed rise; no incident-stone endpoint and no extrapolation to ordinary food intake. exposure: Ascorbic acid 1000 mg twice daily for six days versus no supplement for six days; 13C2 oxalate challenge after adaptation. cross_nutrient: Oxalate is relevant to calcium oxalate stone chemistry. [c-massey2005] Ascorbate increases human oxaluria and kidney stone risk (2005). https://pubmed.ncbi.nlm.nih.gov/15987848/ DOI: 10.1093/jn/135.7.1673
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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