{"id":"e9cd8206-0c96-5875-ac3c-3eaa1cec9850","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-oxalate-low-magnesium","predicate":"reduces","statement":"Boron supplementation decreased total urinary oxalate in the low-magnesium group.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"ebeea835-9303-5a74-9c4b-e5fa47635cd8","mechanism_event_label":"Less oxalate appeared in urine in this setting; fewer kidney stones were not demonstrated.","subject":{"id":"5144a867-de17-599d-baec-68500e3d40bd","slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"},"object":{"id":"27cf19b4-41d7-5f81-8151-48667672310c","slug":"urinary-oxalate-excretion","display_name":"Urinary oxalate excretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"ebeea835-9303-5a74-9c4b-e5fa47635cd8","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-oxalate-low-magnesium-event","event_type":"observed_intervention","label":"Less oxalate appeared in urine in this setting; fewer kidney stones were not demonstrated.","description":"Boron supplementation decreased total urinary oxalate in the low-magnesium group.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1f0c42f0-eaf3-5b86-966d-7ffc8a84872b","slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"},"role":"dietary_context","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9c8d2b72-517d-5bb6-8589-cabd98267f65","slug":"oxalate","display_name":"Oxalate","entity_type_key":"ion"},"role":"measured_compound","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"5144a867-de17-599d-baec-68500e3d40bd","slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"27cf19b4-41d7-5f81-8151-48667672310c","slug":"urinary-oxalate-excretion","display_name":"Urinary oxalate excretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/boron-research/9062533.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"a23cd1fe09277bdd83b690746d4bbaf4742cdd74e51d5b27ee898bd87208b2be\", \"start_char\": 0, \"end_char\": 1720, \"text_sha256\": \"a23cd1fe09277bdd83b690746d4bbaf4742cdd74e51d5b27ee898bd87208b2be\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Metabolic-ward feeding; 11 postmenopausal volunteers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"167-day study; basal 0.36 mg B and 109 mg Mg/8400 kJ; 3 mg/day B supplement in last two 24-day periods; magnesium supplement 0 or 200 mg/day","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small study with multiple dietary periods and supplements. Do not assume independence from related reports from the same research program. Urine composition is not a kidney-stone clinical endpoint.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Boron research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Less oxalate appeared in urine in this setting; fewer kidney stones were not demonstrated.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[boron-p9062533] Metabolic responses of postmenopausal women to supplemental dietary boron and aluminum during usual and low magnesium intake: boron, calcium, and magnesium absorption and retention and blood mineral concentrations. (1997). https://pubmed.ncbi.nlm.nih.gov/9062533/ DOI: 10.1093/ajcn/65.3.803","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Mineral balance, blood and excreta","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"21560808-7773-5723-b662-b516f5976c03","evidence_kind":"source_excerpt","locator":"Lines 677-688","start_line":677,"end_line":688,"excerpt":"### boron-oxalate-low-magnesium\nBoron supplementation decreased total urinary oxalate in the low-magnesium group.\nCondition category: nutrient_deficiency\nnutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Less oxalate appeared in urine in this setting; fewer kidney stones were not demonstrated.\norganism: Human\ntissue_or_cell_type: Mineral balance, blood and excreta\nexperimental_model: Metabolic-ward feeding; 11 postmenopausal volunteers\nlimitations: Small study with multiple dietary periods and supplements. Do not assume independence from related reports from the same research program. Urine composition is not a kidney-stone clinical endpoint.\nexposure: 167-day study; basal 0.36 mg B and 109 mg Mg/8400 kJ; 3 mg/day B supplement in last two 24-day periods; magnesium supplement 0 or 200 mg/day\nevidence_span: {\"source_cache\": \"artifacts/boron-research/9062533.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"a23cd1fe09277bdd83b690746d4bbaf4742cdd74e51d5b27ee898bd87208b2be\", \"start_char\": 0, \"end_char\": 1720, \"text_sha256\": \"a23cd1fe09277bdd83b690746d4bbaf4742cdd74e51d5b27ee898bd87208b2be\"}\n[boron-p9062533] Metabolic responses of postmenopausal women to supplemental dietary boron and aluminum during usual and low magnesium intake: boron, calcium, and magnesium absorption and retention and blood mineral concentrations. (1997). https://pubmed.ncbi.nlm.nih.gov/9062533/ DOI: 10.1093/ajcn/65.3.803","model_system":"Metabolic-ward feeding; 11 postmenopausal volunteers","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [boron-p9062533] Metabolic responses of postmenopausal women to supplemental dietary boron and aluminum during usual and low magnesium intake: boron, calcium, and magnesium absorption and retention and blood mineral concentrations. 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