{"id":"fd948bac-91ca-59e4-b17f-d4223789e696","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:cal-meal-urinary-oxalate","predicate":"has_reported_effect_on","statement":"Calcium carbonate with meals lowered urinary oxalate from baseline; bedtime dosing did not.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"e5802751-78f6-59b4-b150-88849a283da7","mechanism_event_label":"Taking the tested preparation with food changed oxalate handling.","subject":{"id":"4ee1cbd0-1cec-58e1-9fee-bdb2c13db94d","slug":"calcium-carbonate","display_name":"Calcium carbonate","entity_type_key":"chemical_species"},"object":{"id":"27cf19b4-41d7-5f81-8151-48667672310c","slug":"urinary-oxalate-excretion","display_name":"Urinary oxalate excretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"e5802751-78f6-59b4-b150-88849a283da7","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:cal-meal-urinary-oxalate-event","event_type":"observed_intervention","label":"Taking the tested preparation with food changed oxalate handling.","description":"Calcium carbonate with meals lowered urinary oxalate from baseline; bedtime dosing did not.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4ee1cbd0-1cec-58e1-9fee-bdb2c13db94d","slug":"calcium-carbonate","display_name":"Calcium carbonate","entity_type_key":"chemical_species"},"role":"tested_input","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"27cf19b4-41d7-5f81-8151-48667672310c","slug":"urinary-oxalate-excretion","display_name":"Urinary oxalate excretion","entity_type_key":"cellular_process"},"role":"measured_outcome","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9c8d2b72-517d-5bb6-8589-cabd98267f65","slug":"oxalate","display_name":"Oxalate","entity_type_key":"ion"},"role":"measured_solute","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"32 healthy men, one-week crossover regimens.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"1 g calcium carbonate with each of three meals versus 3 g carbonate at bedtime: compound mass, not 3 g elemental calcium.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This experiment measured urine, not long-term stone incidence.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Calcium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Taking the tested preparation with food changed oxalate handling.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[cal-clin-domrong2004] Schedule of taking calcium supplement and the risk of nephrolithiasis (2004). https://pubmed.ncbi.nlm.nih.gov/15086924/ DOI: 10.1111/j.1523-1755.2004.00587.x","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human clinical or absorption endpoint","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"6c33e278-64fe-5e53-a41c-ab38a95266b9","evidence_kind":"source_excerpt","locator":"Lines 1258-1268","start_line":1258,"end_line":1268,"excerpt":"### cal-meal-urinary-oxalate\nCalcium carbonate with meals lowered urinary oxalate from baseline; bedtime dosing did not.\nCondition category: normal\nnutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Taking the tested preparation with food changed oxalate handling.\norganism: Homo sapiens\ntissue_or_cell_type: Human clinical or absorption endpoint\nexperimental_model: 32 healthy men, one-week crossover regimens.\nlimitations: This experiment measured urine, not long-term stone incidence.\nexposure: 1 g calcium carbonate with each of three meals versus 3 g carbonate at bedtime: compound mass, not 3 g elemental calcium.\n[cal-clin-domrong2004] Schedule of taking calcium supplement and the risk of nephrolithiasis (2004). https://pubmed.ncbi.nlm.nih.gov/15086924/ DOI: 10.1111/j.1523-1755.2004.00587.x","model_system":"32 healthy men, one-week crossover regimens.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [cal-clin-domrong2004] Schedule of taking calcium supplement and the risk of nephrolithiasis (2004). https://pubmed.ncbi.nlm.nih.gov/15086924/ DOI: 10.1111/j.1523-1755.2004.00587.x","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3c083fa0-59c6-50e9-af42-678d0e3c1006","stable_key":"import-434e1e27-eb90-583a-956b-62472726ffba","title":"Calcium: mechanism-first literature curation (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"965c934d6b147f2b62f8d45ce6d7a87681a600bfe5c46a585b4704889afd3fc1","revision_id":"543ec48b-4f70-5197-9d76-f5a3c443664c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}