{"id":"48615655-e855-5cb3-bed8-0c034e2f50ad","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:cal-borghi-urinary-oxalate","predicate":"has_reported_effect_on","statement":"Urinary oxalate rose with the low-calcium diet but fell with the normal-calcium, lower-protein, lower-salt diet.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"54bb9ef1-8d25-575d-8e3b-07e345ea2b32","mechanism_event_label":"Diet composition changed urinary oxalate as well as calcium.","subject":{"id":"8e2a5a1f-cd49-5f28-8611-325266fb78a6","slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"},"object":{"id":"27cf19b4-41d7-5f81-8151-48667672310c","slug":"urinary-oxalate-excretion","display_name":"Urinary oxalate excretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"54bb9ef1-8d25-575d-8e3b-07e345ea2b32","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:cal-borghi-urinary-oxalate-event","event_type":"observed_intervention","label":"Diet composition changed urinary oxalate as well as calcium.","description":"Urinary oxalate rose with the low-calcium diet but fell with the normal-calcium, lower-protein, lower-salt diet.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8e2a5a1f-cd49-5f28-8611-325266fb78a6","slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"},"role":"tested_input","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"27cf19b4-41d7-5f81-8151-48667672310c","slug":"urinary-oxalate-excretion","display_name":"Urinary oxalate excretion","entity_type_key":"cellular_process"},"role":"measured_outcome","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9c8d2b72-517d-5bb6-8589-cabd98267f65","slug":"oxalate","display_name":"Oxalate","entity_type_key":"ion"},"role":"measured_solute","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Same randomized dietary trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Urine result supports a plausible intestinal explanation but does not isolate binding or prove mediation of recurrence.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Calcium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Diet composition changed urinary oxalate as well as calcium.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[cal-clin-borghi2002] Comparison of two diets for the prevention of recurrent stones in idiopathic hypercalciuria (2002). https://pubmed.ncbi.nlm.nih.gov/11784873/ DOI: 10.1056/NEJMoa010369","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human clinical or absorption endpoint","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"49c61329-5d23-5d26-8a9c-32cfc53cd65b","evidence_kind":"source_excerpt","locator":"Lines 1247-1256","start_line":1247,"end_line":1256,"excerpt":"### cal-borghi-urinary-oxalate\nUrinary oxalate rose with the low-calcium diet but fell with the normal-calcium, lower-protein, lower-salt diet.\nCondition category: normal\nnutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Diet composition changed urinary oxalate as well as calcium.\norganism: Homo sapiens\ntissue_or_cell_type: Human clinical or absorption endpoint\nexperimental_model: Same randomized dietary trial.\nlimitations: Urine result supports a plausible intestinal explanation but does not isolate binding or prove mediation of recurrence.\n[cal-clin-borghi2002] Comparison of two diets for the prevention of recurrent stones in idiopathic hypercalciuria (2002). https://pubmed.ncbi.nlm.nih.gov/11784873/ DOI: 10.1056/NEJMoa010369","model_system":"Same randomized dietary trial.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [cal-clin-borghi2002] Comparison of two diets for the prevention of recurrent stones in idiopathic hypercalciuria (2002). https://pubmed.ncbi.nlm.nih.gov/11784873/ DOI: 10.1056/NEJMoa010369","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3c083fa0-59c6-50e9-af42-678d0e3c1006","stable_key":"import-434e1e27-eb90-583a-956b-62472726ffba","title":"Calcium: mechanism-first literature curation (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"965c934d6b147f2b62f8d45ce6d7a87681a600bfe5c46a585b4704889afd3fc1","revision_id":"543ec48b-4f70-5197-9d76-f5a3c443664c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}