Component
PLCG1
Independent entity for contextual scientific-audit claims; no universal nutritional effect implied.
3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Adding t10,c12 CLA increased plasma-membrane PLC-gamma1 abundance within three minutes.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Primary human adipocyte localization experiment.
- limitations
- Localization is not proof of direct CLA binding or identification of its receptor.
- nutrient_topic
- CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
- plain_language
- A lipid-signaling enzyme moved toward the membrane.
- primary_references
- The phospholipase C inhibitor U73122 attenuates trans-10, cis-12 conjugated linoleic acid-mediated inflammatory signaling and insulin resistance in human adipocytes. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23468551/ · DOI 10.3945/jn.112.173161
Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 166–172
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Primary human adipocyte localization experiment. · source_derived_draft · unverified_draft
## cla-plc-location A lipid-signaling enzyme moved toward the membrane. Adding t10,c12 CLA increased plasma-membrane PLC-gamma1 abundance within three minutes. Model: Primary human adipocyte localization experiment. Limitations: Localization is not proof of direct CLA binding or identification of its receptor. Evidence access: Primary abstract The phospholipase C inhibitor U73122 attenuates trans-10, cis-12 conjugated linoleic acid-mediated inflammatory signaling and insulin resistance in human adipocytes. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23468551/ · DOI 10.3945/jn.112.173161
Complete structured claim and evidence
Where it participates (unsigned role)
PLC inhibitor U73122 attenuated CLA-induced calcium accumulation, inflammatory signaling and impaired glucose uptake.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Human adipocyte inhibitor experiment.
- limitations
- Broad inhibitor evidence does not isolate PLC-gamma1 as necessary.
- nutrient_topic
- CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
- plain_language
- A phospholipase-sensitive step linked membrane signaling to calcium.
- primary_references
- The phospholipase C inhibitor U73122 attenuates trans-10, cis-12 conjugated linoleic acid-mediated inflammatory signaling and insulin resistance in human adipocytes. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23468551/ · DOI 10.3945/jn.112.173161
Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 174–180
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Human adipocyte inhibitor experiment. · source_derived_draft · unverified_draft
## cla-plc-block A phospholipase-sensitive step linked membrane signaling to calcium. PLC inhibitor U73122 attenuated CLA-induced calcium accumulation, inflammatory signaling and impaired glucose uptake. Model: Human adipocyte inhibitor experiment. Limitations: Broad inhibitor evidence does not isolate PLC-gamma1 as necessary. Evidence access: Primary abstract The phospholipase C inhibitor U73122 attenuates trans-10, cis-12 conjugated linoleic acid-mediated inflammatory signaling and insulin resistance in human adipocytes. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23468551/ · DOI 10.3945/jn.112.173161
Complete structured claim and evidenceGSDMD-N-induced cytotoxicity involves PLCG1 and calcium downstream of GSDMD cleavage in the tested macrophage model.
Experimental context and source evidence
- cell_type
- Macrophages
- experimental_model
- Myeloid Gpx4 models, macrophage cytosolic LPS/E. coli and mouse sepsis
- limitations
- Does not put PLCG1 downstream in every inflammatory signaling pathway.
- organism
- Mus musculus
Selenium: literature corrections and mechanism additions · lines 1396–1406
Metabolic Ledger literature curation, 17 September 2026; primary papers linked individually · supports · Myeloid Gpx4 models, macrophage cytosolic LPS/E. coli and mouse sepsis · secondary_verified · secondary_verified
## gsdmd-plcg1 The PLCG1/calcium execution phase follows gasdermin cleavage. GSDMD-N-induced cytotoxicity involves PLCG1 and calcium downstream of GSDMD cleavage in the tested macrophage model. Organism: Mus musculus Cell type: Macrophages Experimental model: Myeloid Gpx4 models, macrophage cytosolic LPS/E. coli and mouse sepsis Limitations: Does not put PLCG1 downstream in every inflammatory signaling pathway. Primary reference: [Lipid peroxidation drives gasdermin D-mediated pyroptosis in lethal polymicrobial sepsis](https://pmc.ncbi.nlm.nih.gov/articles/PMC6043361/)
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.