Component

Human adipocyte intracellular calcium response

Context-specific entity; species, compartment and exposure are stated on each claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Adding t10,c12 CLA increased intracellular calcium; BAPTA and the calcium-mobilization inhibitor TMB-8 attenuated the increase.

    trans-10,cis-12 conjugated linoleic acid → Human adipocyte intracellular calcium response source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Primary human adipocytes with pharmacological perturbation.
    limitations
    Does not mean dietary calcium causes the effect or that a unique channel was identified.
    nutrient_topic
    CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
    plain_language
    A local calcium signal helped initiate the response.
    primary_references
    Inflammation and insulin resistance induced by trans-10, cis-12 conjugated linoleic acid depend on intracellular calcium levels in primary cultures of human adipocytes. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20154361/ · DOI 10.1194/jlr.M005447

    Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 150–156

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Primary human adipocytes with pharmacological perturbation. · source_derived_draft · unverified_draft

    ## cla-calcium A local calcium signal helped initiate the response. Adding t10,c12 CLA increased intracellular calcium; BAPTA and the calcium-mobilization inhibitor TMB-8 attenuated the increase. Model: Primary human adipocytes with pharmacological perturbation. Limitations: Does not mean dietary calcium causes the effect or that a unique channel was identified. Evidence access: Primary abstract Inflammation and insulin resistance induced by trans-10, cis-12 conjugated linoleic acid depend on intracellular calcium levels in primary cultures of human adipocytes. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20154361/ · DOI 10.1194/jlr.M005447
    Complete structured claim and evidence

  2. DGK inhibitor R59022 attenuated CLA-induced calcium accumulation and reductions in glucose/fatty-acid uptake.

    R59022, pharmacological DGK inhibitor → Human adipocyte intracellular calcium response source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Primary human adipocytes, R59022 pretreatment.
    limitations
    The inhibitor does not establish DGK-eta as the calcium-controlling isoform.
    nutrient_topic
    CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
    plain_language
    Pharmacological results connected lipid signaling and calcium.
    primary_references
    Diacylglycerol kinase inhibitor R59022 attenuates conjugated linoleic acid-mediated inflammation in human adipocytes. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23264678/ · DOI 10.1194/jlr.M031211

    Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 198–204

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Primary human adipocytes, R59022 pretreatment. · source_derived_draft · unverified_draft

    ## cla-dgk-inhibitor Pharmacological results connected lipid signaling and calcium. DGK inhibitor R59022 attenuated CLA-induced calcium accumulation and reductions in glucose/fatty-acid uptake. Model: Primary human adipocytes, R59022 pretreatment. Limitations: The inhibitor does not establish DGK-eta as the calcium-controlling isoform. Evidence access: Primary abstract Diacylglycerol kinase inhibitor R59022 attenuates conjugated linoleic acid-mediated inflammation in human adipocytes. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23264678/ · DOI 10.1194/jlr.M031211
    Complete structured claim and evidence

  3. PLC inhibitor U73122 attenuated CLA-induced calcium accumulation, inflammatory signaling and impaired glucose uptake.

    U73122, pharmacological PLC inhibitor → Human adipocyte intracellular calcium response source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Human adipocyte inhibitor experiment.
    limitations
    Broad inhibitor evidence does not isolate PLC-gamma1 as necessary.
    nutrient_topic
    CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
    plain_language
    A phospholipase-sensitive step linked membrane signaling to calcium.
    primary_references
    The phospholipase C inhibitor U73122 attenuates trans-10, cis-12 conjugated linoleic acid-mediated inflammatory signaling and insulin resistance in human adipocytes. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23468551/ · DOI 10.3945/jn.112.173161

    Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 174–180

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Human adipocyte inhibitor experiment. · source_derived_draft · unverified_draft

    ## cla-plc-block A phospholipase-sensitive step linked membrane signaling to calcium. PLC inhibitor U73122 attenuated CLA-induced calcium accumulation, inflammatory signaling and impaired glucose uptake. Model: Human adipocyte inhibitor experiment. Limitations: Broad inhibitor evidence does not isolate PLC-gamma1 as necessary. Evidence access: Primary abstract The phospholipase C inhibitor U73122 attenuates trans-10, cis-12 conjugated linoleic acid-mediated inflammatory signaling and insulin resistance in human adipocytes. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23468551/ · DOI 10.3945/jn.112.173161
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards