Component
cleaved GSDMD N-terminal fragment
Independent entity for contextual scientific-audit claims; no universal nutritional effect implied.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
GSDMD-N-induced cytotoxicity involves PLCG1 and calcium downstream of GSDMD cleavage in the tested macrophage model.
Experimental context and source evidence
- cell_type
- Macrophages
- experimental_model
- Myeloid Gpx4 models, macrophage cytosolic LPS/E. coli and mouse sepsis
- limitations
- Does not put PLCG1 downstream in every inflammatory signaling pathway.
- organism
- Mus musculus
Selenium: literature corrections and mechanism additions · lines 1396–1406
Metabolic Ledger literature curation, 17 September 2026; primary papers linked individually · supports · Myeloid Gpx4 models, macrophage cytosolic LPS/E. coli and mouse sepsis · secondary_verified · secondary_verified
## gsdmd-plcg1 The PLCG1/calcium execution phase follows gasdermin cleavage. GSDMD-N-induced cytotoxicity involves PLCG1 and calcium downstream of GSDMD cleavage in the tested macrophage model. Organism: Mus musculus Cell type: Macrophages Experimental model: Myeloid Gpx4 models, macrophage cytosolic LPS/E. coli and mouse sepsis Limitations: Does not put PLCG1 downstream in every inflammatory signaling pathway. Primary reference: [Lipid peroxidation drives gasdermin D-mediated pyroptosis in lethal polymicrobial sepsis](https://pmc.ncbi.nlm.nih.gov/articles/PMC6043361/)
Complete structured claim and evidence
What acts on it
Inflammatory caspase activation cleaves GSDMD to produce its cytotoxic N-terminal fragment in the inspected pyroptosis pathway.
Experimental context and source evidence
- cell_type
- Macrophages
- experimental_model
- Myeloid Gpx4 models, macrophage cytosolic LPS/E. coli and mouse sepsis
- limitations
- Not a demonstrated complete human dietary-deficiency sequence.
- organism
- Mus musculus
Selenium: literature corrections and mechanism additions · lines 1384–1394
Metabolic Ledger literature curation, 17 September 2026; primary papers linked individually · supports · Myeloid Gpx4 models, macrophage cytosolic LPS/E. coli and mouse sepsis · secondary_verified · secondary_verified
## caspase-gsdmd Caspases cut gasdermin before its execution fragment acts. Inflammatory caspase activation cleaves GSDMD to produce its cytotoxic N-terminal fragment in the inspected pyroptosis pathway. Organism: Mus musculus Cell type: Macrophages Experimental model: Myeloid Gpx4 models, macrophage cytosolic LPS/E. coli and mouse sepsis Limitations: Not a demonstrated complete human dietary-deficiency sequence. Primary reference: [Lipid peroxidation drives gasdermin D-mediated pyroptosis in lethal polymicrobial sepsis](https://pmc.ncbi.nlm.nih.gov/articles/PMC6043361/)
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.