Component

Human ornithine decarboxylase / ODC1

Study-scoped entity; inspect species, exposure and experimental limitations on each claim.

6 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Three ODC1-directed siRNAs depleted polyamines and reduced starvation-induced autophagic flux.

    Human ornithine decarboxylase / ODC1 → Human U2OS/H4 starvation-induced autophagic flux source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_access
    Primary full text
    experimental_model
    Human U2OS cells.
    limitations
    ODC1 supplies several polyamines; depletion is not spermidine-specific.
    nutrient_topic
    Spermidine collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Spermidine
    plain_language
    Genetic evidence complements the inhibitor experiment.
    primary_references
    Spermidine is essential for fasting-mediated autophagy and longevity. · 2024 · https://pubmed.ncbi.nlm.nih.gov/39117797/ · DOI 10.1038/s41556-024-01468-x
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Spermidine: biosynthesis, hypusination, transport and cross-nutrient mechanisms (2026-09-19) · lines 198–204

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human U2OS cells. · source_derived_draft · unverified_draft

    ## spermidine-fasting-knockdown Genetic evidence complements the inhibitor experiment. Three ODC1-directed siRNAs depleted polyamines and reduced starvation-induced autophagic flux. Model: Human U2OS cells. Limitations: ODC1 supplies several polyamines; depletion is not spermidine-specific. Evidence access: Primary full text Spermidine is essential for fasting-mediated autophagy and longevity. · 2024 · https://pubmed.ncbi.nlm.nih.gov/39117797/ · DOI 10.1038/s41556-024-01468-x
    Complete structured claim and evidence

  2. DFMO inhibition of ODC1 reduced starvation-induced autophagic flux in U2OS and H4 cells.

    Human ornithine decarboxylase / ODC1 → Human U2OS/H4 starvation-induced autophagic flux source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_access
    Primary full text
    experimental_model
    Human tumor cell lines; 100 micromolar DFMO pretreatment and short HBSS starvation.
    limitations
    Pharmacological depletion differs from ordinary low dietary intake.
    nutrient_topic
    Spermidine collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Spermidine
    plain_language
    Blocking polyamine production can interrupt the fasting response.
    primary_references
    Spermidine is essential for fasting-mediated autophagy and longevity. · 2024 · https://pubmed.ncbi.nlm.nih.gov/39117797/ · DOI 10.1038/s41556-024-01468-x
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Spermidine: biosynthesis, hypusination, transport and cross-nutrient mechanisms (2026-09-19) · lines 182–188

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human tumor cell lines; 100 micromolar DFMO pretreatment and short HBSS starvation. · source_derived_draft · unverified_draft

    ## spermidine-fasting-odc Blocking polyamine production can interrupt the fasting response. DFMO inhibition of ODC1 reduced starvation-induced autophagic flux in U2OS and H4 cells. Model: Human tumor cell lines; 100 micromolar DFMO pretreatment and short HBSS starvation. Limitations: Pharmacological depletion differs from ordinary low dietary intake. Evidence access: Primary full text Spermidine is essential for fasting-mediated autophagy and longevity. · 2024 · https://pubmed.ncbi.nlm.nih.gov/39117797/ · DOI 10.1038/s41556-024-01468-x
    Complete structured claim and evidence

What acts on it

  1. Biochemical binding and structural experiments identify PLP as the human ODC coenzyme.

    PLP → Human ornithine decarboxylase / ODC1 source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Human and Leishmania ODC comparison; human inhibitor-bound structure.
    limitations
    Cofactor dependence does not establish that extra B6 raises polyamines in a replete person.
    nutrient_topic
    L-Arginine collection; tissue, species, dose and formulation distinctions retained. · L-Arginine
    plain_language
    The polyamine branch connects to vitamin B6.
    primary_references
    A structural insight into the inhibition of human and Leishmania donovani ornithine decarboxylases by 1-amino-oxy-3-aminopropane. · 2007 · https://pubmed.ncbi.nlm.nih.gov/17407445/ · DOI 10.1042/bj20070188

    L-Arginine: transport, metabolic branches, nutrient interactions, availability and discovery questions (2026-09-18) · lines 102–108

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Human and Leishmania ODC comparison; human inhibitor-bound structure. · source_derived_draft · unverified_draft

    ## arg-odc-cofactor The polyamine branch connects to vitamin B6. Biochemical binding and structural experiments identify PLP as the human ODC coenzyme. Model: Human and Leishmania ODC comparison; human inhibitor-bound structure. Limitations: Cofactor dependence does not establish that extra B6 raises polyamines in a replete person. Evidence access: Primary abstract A structural insight into the inhibition of human and Leishmania donovani ornithine decarboxylases by 1-amino-oxy-3-aminopropane. · 2007 · https://pubmed.ncbi.nlm.nih.gov/17407445/ · DOI 10.1042/bj20070188
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Human AZIN2 bound antizymes and counteracted AZ1-dependent suppression and degradation of ODC.

    Human antizyme inhibitor 2 / AZIN2 → Human ornithine decarboxylase antizyme 1 / OAZ1 source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Yeast two-hybrid, binding, ODC activity and degradation assays.
    limitations
    Binding and functional inhibition were studied; no oral supplement response is inferred.
    nutrient_topic
    Agmatine Sulfate collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Agmatine Sulfate
    plain_language
    A regulatory protein can change polyamine supply without synthesizing agmatine itself.
    primary_references
    Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase. · 2008 · https://pubmed.ncbi.nlm.nih.gov/17900240/ · DOI 10.1042/BJ20071004

    Agmatine Sulfate: transport, guanidino metabolism, ion channels and cross-nutrient mechanisms (2026-09-20) · lines 180–186

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Yeast two-hybrid, binding, ODC activity and degradation assays. · source_derived_draft · unverified_draft

    ## agmatine-sulfate-azin2-regulation A regulatory protein can change polyamine supply without synthesizing agmatine itself. Human AZIN2 bound antizymes and counteracted AZ1-dependent suppression and degradation of ODC. Model: Yeast two-hybrid, binding, ODC activity and degradation assays. Limitations: Binding and functional inhibition were studied; no oral supplement response is inferred. Evidence access: Primary abstract Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase. · 2008 · https://pubmed.ncbi.nlm.nih.gov/17900240/ · DOI 10.1042/BJ20071004
    Complete structured claim and evidence

  2. ODC catalyzes conversion of ornithine into putrescine.

    L-Ornithine → Putrescine source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract and indexed primary full-text introduction, PMC1904517
    experimental_model
    Human ODC study; reaction identified in the primary paper introduction.
    limitations
    Reaction identity does not establish net pathway flux after supplementation.
    nutrient_topic
    L-Arginine collection; tissue, species, dose and formulation distinctions retained. · L-Arginine
    plain_language
    This reaction opens the polyamine branch.
    primary_references
    A structural insight into the inhibition of human and Leishmania donovani ornithine decarboxylases by 1-amino-oxy-3-aminopropane. · 2007 · https://pubmed.ncbi.nlm.nih.gov/17407445/ · DOI 10.1042/bj20070188

    L-Arginine: transport, metabolic branches, nutrient interactions, availability and discovery questions (2026-09-18) · lines 110–116

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Human ODC study; reaction identified in the primary paper introduction. · source_derived_draft · unverified_draft

    ## arg-odc-reaction This reaction opens the polyamine branch. ODC catalyzes conversion of ornithine into putrescine. Model: Human ODC study; reaction identified in the primary paper introduction. Limitations: Reaction identity does not establish net pathway flux after supplementation. Evidence access: Primary abstract and indexed primary full-text introduction, PMC1904517 A structural insight into the inhibition of human and Leishmania donovani ornithine decarboxylases by 1-amino-oxy-3-aminopropane. · 2007 · https://pubmed.ncbi.nlm.nih.gov/17407445/ · DOI 10.1042/bj20070188
    Complete structured claim and evidence

  3. Tracer carbon appeared in putrescine and proline; arginase inhibition reduced these labeled products.

    L-Arginine → Putrescine source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Full-text results, Figures 2 and 6, Europe PMC PMC5075284; primary abstract.
    experimental_model
    Primary human activated T cells; isotope tracing and functional assays.
    limitations
    Flux is model-specific; not evidence of clinical wound healing.
    nutrient_topic
    L-Arginine collection; tissue, species, dose and formulation distinctions retained. · L-Arginine
    plain_language
    Arginine fed more than the NO pathway.
    primary_references
    L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27745970/ · DOI 10.1016/j.cell.2016.09.031

    L-Arginine: transport, metabolic branches, nutrient interactions, availability and discovery questions (2026-09-18) · lines 222–228

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Primary human activated T cells; isotope tracing and functional assays. · source_derived_draft · unverified_draft

    ## arg-tcell-carbon Arginine fed more than the NO pathway. Tracer carbon appeared in putrescine and proline; arginase inhibition reduced these labeled products. Model: Primary human activated T cells; isotope tracing and functional assays. Limitations: Flux is model-specific; not evidence of clinical wound healing. Evidence access: Full-text results, Figures 2 and 6, Europe PMC PMC5075284; primary abstract. L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27745970/ · DOI 10.1016/j.cell.2016.09.031
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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