{"id":"4d4a945c-6cf8-5568-9785-ce1c9461349e","stable_key":"fd37d270-3395-56d6-9f1c-ddda56e606f6:arg-odc-reaction","predicate":"decarboxylated_to","statement":"ODC catalyzes conversion of ornithine into putrescine.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"ca771158-6d00-51fb-a377-4bfd6a8ef993","mechanism_event_label":"This reaction opens the polyamine branch.","subject":{"id":"c715e48e-42db-5fac-b4a4-c1285a68d085","slug":"ornithine","display_name":"L-Ornithine","entity_type_key":"small_molecule"},"object":{"id":"c71bf622-f14b-5314-b1a5-dfa002d2d8ff","slug":"putrescine","display_name":"Putrescine","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"ca771158-6d00-51fb-a377-4bfd6a8ef993","stable_key":"fd37d270-3395-56d6-9f1c-ddda56e606f6:arg-odc-reaction-event","event_type":"observed_relationship","label":"This reaction opens the polyamine branch.","description":"ODC catalyzes conversion of ornithine into putrescine.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c715e48e-42db-5fac-b4a4-c1285a68d085","slug":"ornithine","display_name":"L-Ornithine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c71bf622-f14b-5314-b1a5-dfa002d2d8ff","slug":"putrescine","display_name":"Putrescine","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"f8b362af-6bb4-5955-92a8-22ade1d2a716","slug":"odc1","display_name":"Human ornithine decarboxylase / ODC1","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"6b656ff5-9532-5da4-8eea-8ca163a48649","slug":"pyridoxal-phosphate","display_name":"PLP","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract and indexed primary full-text introduction, PMC1904517","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human ODC study; reaction identified in the primary paper introduction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Reaction identity does not establish net pathway flux after supplementation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Arginine collection; tissue, species, dose and formulation distinctions retained.","comparator":null,"unit":null,"notes":"","entity":{"slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"This reaction opens the polyamine branch.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"A structural insight into the inhibition of human and Leishmania donovani ornithine decarboxylases by 1-amino-oxy-3-aminopropane. · 2007 · https://pubmed.ncbi.nlm.nih.gov/17407445/ · DOI 10.1042/bj20070188","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"7b90911b-d57b-50f4-8830-1dcc0491dce0","evidence_kind":"source_excerpt","locator":"Lines 110-116","start_line":110,"end_line":116,"excerpt":"## arg-odc-reaction\nThis reaction opens the polyamine branch.\nODC catalyzes conversion of ornithine into putrescine.\nModel: Human ODC study; reaction identified in the primary paper introduction.\nLimitations: Reaction identity does not establish net pathway flux after supplementation.\nEvidence access: Primary abstract and indexed primary full-text introduction, PMC1904517\nA structural insight into the inhibition of human and Leishmania donovani ornithine decarboxylases by 1-amino-oxy-3-aminopropane. · 2007 · https://pubmed.ncbi.nlm.nih.gov/17407445/ · DOI 10.1042/bj20070188","model_system":"Human ODC study; reaction identified in the primary paper introduction.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; primary evidence access stated per claim.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"bb9a67ea-904f-5b8a-93a4-459081212bdd","stable_key":"import-fd37d270-3395-56d6-9f1c-ddda56e606f6","title":"L-Arginine: transport, metabolic branches, nutrient interactions, availability and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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