{"id":"8ab939ee-f6cd-5af4-9bd3-880dbaeec975","stable_key":"fd37d270-3395-56d6-9f1c-ddda56e606f6:arg-odc-cofactor","predicate":"cofactor_for","statement":"Biochemical binding and structural experiments identify PLP as the human ODC coenzyme.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"6402c8d0-660c-56e3-a40f-008ee86819cf","mechanism_event_label":"The polyamine branch connects to vitamin B6.","subject":{"id":"6b656ff5-9532-5da4-8eea-8ca163a48649","slug":"pyridoxal-phosphate","display_name":"PLP","entity_type_key":"small_molecule"},"object":{"id":"f8b362af-6bb4-5955-92a8-22ade1d2a716","slug":"odc1","display_name":"Human ornithine decarboxylase / ODC1","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"6402c8d0-660c-56e3-a40f-008ee86819cf","stable_key":"fd37d270-3395-56d6-9f1c-ddda56e606f6:arg-odc-cofactor-event","event_type":"observed_relationship","label":"The polyamine branch connects to vitamin B6.","description":"Biochemical binding and structural experiments identify PLP as the human ODC coenzyme.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6b656ff5-9532-5da4-8eea-8ca163a48649","slug":"pyridoxal-phosphate","display_name":"PLP","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f8b362af-6bb4-5955-92a8-22ade1d2a716","slug":"odc1","display_name":"Human ornithine decarboxylase / ODC1","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c715e48e-42db-5fac-b4a4-c1285a68d085","slug":"ornithine","display_name":"L-Ornithine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human and Leishmania ODC comparison; human inhibitor-bound structure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Cofactor dependence does not establish that extra B6 raises polyamines in a replete person.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Arginine collection; tissue, species, dose and formulation distinctions retained.","comparator":null,"unit":null,"notes":"","entity":{"slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The polyamine branch connects to vitamin B6.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"A structural insight into the inhibition of human and Leishmania donovani ornithine decarboxylases by 1-amino-oxy-3-aminopropane. · 2007 · https://pubmed.ncbi.nlm.nih.gov/17407445/ · DOI 10.1042/bj20070188","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b664915b-574f-5422-9389-1b7e2e9851d6","evidence_kind":"source_excerpt","locator":"Lines 102-108","start_line":102,"end_line":108,"excerpt":"## arg-odc-cofactor\nThe polyamine branch connects to vitamin B6.\nBiochemical binding and structural experiments identify PLP as the human ODC coenzyme.\nModel: Human and Leishmania ODC comparison; human inhibitor-bound structure.\nLimitations: Cofactor dependence does not establish that extra B6 raises polyamines in a replete person.\nEvidence access: Primary abstract\nA structural insight into the inhibition of human and Leishmania donovani ornithine decarboxylases by 1-amino-oxy-3-aminopropane. · 2007 · https://pubmed.ncbi.nlm.nih.gov/17407445/ · DOI 10.1042/bj20070188","model_system":"Human and Leishmania ODC comparison; human inhibitor-bound structure.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; primary evidence access stated per claim.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"bb9a67ea-904f-5b8a-93a4-459081212bdd","stable_key":"import-fd37d270-3395-56d6-9f1c-ddda56e606f6","title":"L-Arginine: transport, metabolic branches, nutrient interactions, availability and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"ec0e9a3fb72b7485534e4372a074ac7624a399ff962e55690eb462217b5149ec","revision_id":"af027270-5535-51ae-85ff-9c76c518c962","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}