{"id":"9cbe72ad-3deb-5c7a-8fea-e38cfca406e1","stable_key":"fd37d270-3395-56d6-9f1c-ddda56e606f6:arg-tcell-carbon","predicate":"contributes_carbon_to","statement":"Tracer carbon appeared in putrescine and proline; arginase inhibition reduced these labeled products.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"2c3a6b42-0f9f-59ef-b6a5-18086995b4e8","mechanism_event_label":"Arginine fed more than the NO pathway.","subject":{"id":"eeca3c9e-7749-5677-b7bd-37fe8f7c228d","slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"},"object":{"id":"c71bf622-f14b-5314-b1a5-dfa002d2d8ff","slug":"putrescine","display_name":"Putrescine","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"2c3a6b42-0f9f-59ef-b6a5-18086995b4e8","stable_key":"fd37d270-3395-56d6-9f1c-ddda56e606f6:arg-tcell-carbon-event","event_type":"observed_relationship","label":"Arginine fed more than the NO pathway.","description":"Tracer carbon appeared in putrescine and proline; 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primary abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Primary human activated T cells; isotope tracing and functional assays.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Flux is model-specific; not evidence of clinical wound healing.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Arginine collection; tissue, species, dose and formulation distinctions retained.","comparator":null,"unit":null,"notes":"","entity":{"slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Arginine fed more than the NO pathway.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27745970/ · DOI 10.1016/j.cell.2016.09.031","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c38250f8-0098-53bd-8f05-1500056288e6","evidence_kind":"source_excerpt","locator":"Lines 222-228","start_line":222,"end_line":228,"excerpt":"## arg-tcell-carbon\nArginine fed more than the NO pathway.\nTracer carbon appeared in putrescine and proline; arginase inhibition reduced these labeled products.\nModel: Primary human activated T cells; isotope tracing and functional assays.\nLimitations: Flux is model-specific; not evidence of clinical wound healing.\nEvidence access: Full-text results, Figures 2 and 6, Europe PMC PMC5075284; primary abstract.\nL-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27745970/ · DOI 10.1016/j.cell.2016.09.031","model_system":"Primary human activated T cells; isotope tracing and functional assays.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; primary evidence access stated per claim.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"bb9a67ea-904f-5b8a-93a4-459081212bdd","stable_key":"import-fd37d270-3395-56d6-9f1c-ddda56e606f6","title":"L-Arginine: transport, metabolic branches, nutrient interactions, availability and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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