Component

Nocturnal circulating melatonin concentration

Nocturnal circulating melatonin concentration. Species, exposure and limitations are retained in each linked claim.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. All tested atenolol doses reduced nocturnal melatonin relative to placebo, with a dose-dependent pattern.

    Atenolol → Nocturnal circulating melatonin concentration source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/melatonin-research/9406983.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7d3fe9b237757bb5797ed40bbc26931a04868f9160ea458dd1264671c77e0718", "start_char": 0, "end_char": 1175, "text_sha256": "7d3fe9b237757bb5797ed40bbc26931a04868f9160ea458dd1264671c77e0718"}
    experimental_model
    Randomized single-blind dose-response study
    exposure
    Atenolol 12.5, 25, 37.5 or 50 mg versus placebo; week washouts
    limitations
    Acute beta1 blockade and small sample. A lower concentration does not by itself establish symptomatic deficiency or a need for replacement.
    nutrient_topic
    Melatonin research collection; topical membership is not evidence of a direct dietary effect. · Melatonin
    organism
    Six healthy humans
    plain_language
    A medicine can weaken the normal secretion signal even when synthetic nutrients are available.
    primary_references
    [melatonin-p9406983] The effect of atenolol, a beta1-adrenergic antagonist, on nocturnal plasma melatonin secretion: evidence for a dose-response relationship in humans. (1997). https://pubmed.ncbi.nlm.nih.gov/9406983/ DOI: 10.1111/j.1600-079x.1997.tb00345.x
    tissue_or_cell_type
    Nocturnal melatonin secretion
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Melatonin: synthesis, receptors, circadian timing and nutrient interactions (2026-09-17) · lines 968–979

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized single-blind dose-response study · source_derived_draft · unverified_draft

    ### melatonin-atenolol-suppression All tested atenolol doses reduced nocturnal melatonin relative to placebo, with a dose-dependent pattern. Condition category: machinery_impairment nutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect. plain_language: A medicine can weaken the normal secretion signal even when synthetic nutrients are available. organism: Six healthy humans tissue_or_cell_type: Nocturnal melatonin secretion experimental_model: Randomized single-blind dose-response study limitations: Acute beta1 blockade and small sample. A lower concentration does not by itself establish symptomatic deficiency or a need for replacement. exposure: Atenolol 12.5, 25, 37.5 or 50 mg versus placebo; week washouts evidence_span: {"source_cache": "artifacts/melatonin-research/9406983.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7d3fe9b237757bb5797ed40bbc26931a04868f9160ea458dd1264671c77e0718", "start_char": 0, "end_char": 1175, "text_sha256": "7d3fe9b237757bb5797ed40bbc26931a04868f9160ea458dd1264671c77e0718"} [melatonin-p9406983] The effect of atenolol, a beta1-adrenergic antagonist, on nocturnal plasma melatonin secretion: evidence for a dose-response relationship in humans. (1997). https://pubmed.ncbi.nlm.nih.gov/9406983/ DOI: 10.1111/j.1600-079x.1997.tb00345.x
    Complete structured claim and evidence

  2. Evening pyridoxine did not significantly change melatonin onset, peak, mean or AUC relative to placebo.

    Pyridoxine → Nocturnal circulating melatonin concentration source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/melatonin-research/12080281.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "04727c17cd3152a4749ec25ff15b36b827efb885501ce058d436fbbea1e9e7a9", "start_char": 0, "end_char": 1222, "text_sha256": "04727c17cd3152a4749ec25ff15b36b827efb885501ce058d436fbbea1e9e7a9"}
    experimental_model
    Placebo-controlled evening pyridoxine experiment
    exposure
    100 mg pyridoxine at 17:00; evening/night sampling
    limitations
    Acute exposure in healthy men. Null supplementation response does not negate the enzymatic requirement for PLP or settle effects in B6 deficiency.
    nutrient_topic
    Melatonin research collection; topical membership is not evidence of a direct dietary effect. · Melatonin
    organism
    Twelve healthy men
    plain_language
    An enzyme needs B6, but giving extra B6 did not increase the hormone in this experiment.
    primary_references
    [melatonin-p12080281] The effect of pyridoxine administration on melatonin secretion in normal men. (2002). https://pubmed.ncbi.nlm.nih.gov/12080281/
    tissue_or_cell_type
    Melatonin secretion, temperature and polysomnography

    Melatonin: synthesis, receptors, circadian timing and nutrient interactions (2026-09-17) · lines 773–784

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Placebo-controlled evening pyridoxine experiment · source_derived_draft · unverified_draft

    ### melatonin-b6-secretion-null Evening pyridoxine did not significantly change melatonin onset, peak, mean or AUC relative to placebo. Condition category: normal nutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect. plain_language: An enzyme needs B6, but giving extra B6 did not increase the hormone in this experiment. organism: Twelve healthy men tissue_or_cell_type: Melatonin secretion, temperature and polysomnography experimental_model: Placebo-controlled evening pyridoxine experiment limitations: Acute exposure in healthy men. Null supplementation response does not negate the enzymatic requirement for PLP or settle effects in B6 deficiency. exposure: 100 mg pyridoxine at 17:00; evening/night sampling evidence_span: {"source_cache": "artifacts/melatonin-research/12080281.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "04727c17cd3152a4749ec25ff15b36b827efb885501ce058d436fbbea1e9e7a9", "start_char": 0, "end_char": 1222, "text_sha256": "04727c17cd3152a4749ec25ff15b36b827efb885501ce058d436fbbea1e9e7a9"} [melatonin-p12080281] The effect of pyridoxine administration on melatonin secretion in normal men. (2002). https://pubmed.ncbi.nlm.nih.gov/12080281/
    Complete structured claim and evidence

  3. Light during usual sleep hours suppressed melatonin by more than 50% in most trials.

    Light exposure during biological night → Nocturnal circulating melatonin concentration source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    biomarker_context Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/melatonin-research/21193540.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "899cae7b15ef3be8a3d4660202e8f675722295da9cb69a0eef3bdcf2470aeb23", "start_char": 0, "end_char": 1666, "text_sha256": "899cae7b15ef3be8a3d4660202e8f675722295da9cb69a0eef3bdcf2470aeb23"}
    experimental_model
    Controlled-light profiles analyzed retrospectively
    exposure
    Room light below 200 lux versus dim light below 3 lux before bed; light during usual sleep hours
    limitations
    Study light conditions are not universal thresholds for all eyes, spectra or exposure durations. Suppression is not dietary deficiency.
    nutrient_topic
    Melatonin research collection; topical membership is not evidence of a direct dietary effect. · Melatonin
    organism
    116 healthy adults aged 18-30
    plain_language
    A low sample can have an environmental explanation.
    primary_references
    [melatonin-p21193540] Exposure to room light before bedtime suppresses melatonin onset and shortens melatonin duration in humans. (2011). https://pubmed.ncbi.nlm.nih.gov/21193540/ DOI: 10.1210/jc.2010-2098
    tissue_or_cell_type
    Circulating melatonin under different light conditions
    trigger_kind
    biomarker_context Imported condition classification; unverified.

    Melatonin: synthesis, receptors, circadian timing and nutrient interactions (2026-09-17) · lines 903–914

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Controlled-light profiles analyzed retrospectively · source_derived_draft · unverified_draft

    ### melatonin-light-night-level Light during usual sleep hours suppressed melatonin by more than 50% in most trials. Condition category: biomarker_context nutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect. plain_language: A low sample can have an environmental explanation. organism: 116 healthy adults aged 18-30 tissue_or_cell_type: Circulating melatonin under different light conditions experimental_model: Controlled-light profiles analyzed retrospectively limitations: Study light conditions are not universal thresholds for all eyes, spectra or exposure durations. Suppression is not dietary deficiency. exposure: Room light below 200 lux versus dim light below 3 lux before bed; light during usual sleep hours evidence_span: {"source_cache": "artifacts/melatonin-research/21193540.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "899cae7b15ef3be8a3d4660202e8f675722295da9cb69a0eef3bdcf2470aeb23", "start_char": 0, "end_char": 1666, "text_sha256": "899cae7b15ef3be8a3d4660202e8f675722295da9cb69a0eef3bdcf2470aeb23"} [melatonin-p21193540] Exposure to room light before bedtime suppresses melatonin onset and shortens melatonin duration in humans. (2011). https://pubmed.ncbi.nlm.nih.gov/21193540/ DOI: 10.1210/jc.2010-2098
    Complete structured claim and evidence

  4. Endogenous overnight melatonin AUC was similar during smoking and after abstinence.

    Abstinence from cigarette smoking → Nocturnal circulating melatonin concentration source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/melatonin-research/15824912.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c9b44dc6db12d52916bdcf69db0dd31eec1107fa54539057ea07346f1e69894c", "start_char": 0, "end_char": 1764, "text_sha256": "c9b44dc6db12d52916bdcf69db0dd31eec1107fa54539057ea07346f1e69894c"}
    experimental_model
    Within-person smoking versus seven-day abstinence study
    exposure
    25 mg oral melatonin after nighttime sampling
    limitations
    High pharmacological dose and small cohort. Smoking affected exogenous exposure without a significant endogenous nighttime AUC change; do not conflate the two.
    nutrient_topic
    Melatonin research collection; topical membership is not evidence of a direct dietary effect. · Melatonin
    organism
    Eight habitual smokers
    plain_language
    The supplement result cannot be generalized to the natural night signal.
    primary_references
    [melatonin-p15824912] Influence of cigarette smoking on melatonin levels in man. (2005). https://pubmed.ncbi.nlm.nih.gov/15824912/ DOI: 10.1007/s00228-005-0908-7
    tissue_or_cell_type
    Endogenous night secretion versus exogenous exposure

    Melatonin: synthesis, receptors, circadian timing and nutrient interactions (2026-09-17) · lines 747–758

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Within-person smoking versus seven-day abstinence study · source_derived_draft · unverified_draft

    ### melatonin-smoking-endogenous-null Endogenous overnight melatonin AUC was similar during smoking and after abstinence. Condition category: normal nutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect. plain_language: The supplement result cannot be generalized to the natural night signal. organism: Eight habitual smokers tissue_or_cell_type: Endogenous night secretion versus exogenous exposure experimental_model: Within-person smoking versus seven-day abstinence study limitations: High pharmacological dose and small cohort. Smoking affected exogenous exposure without a significant endogenous nighttime AUC change; do not conflate the two. exposure: 25 mg oral melatonin after nighttime sampling evidence_span: {"source_cache": "artifacts/melatonin-research/15824912.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c9b44dc6db12d52916bdcf69db0dd31eec1107fa54539057ea07346f1e69894c", "start_char": 0, "end_char": 1764, "text_sha256": "c9b44dc6db12d52916bdcf69db0dd31eec1107fa54539057ea07346f1e69894c"} [melatonin-p15824912] Influence of cigarette smoking on melatonin levels in man. (2005). https://pubmed.ncbi.nlm.nih.gov/15824912/ DOI: 10.1007/s00228-005-0908-7
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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