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(2005). https://pubmed.ncbi.nlm.nih.gov/15824912/ DOI: 10.1007/s00228-005-0908-7","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Endogenous night secretion versus exogenous exposure","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"80cdb981-7b0c-565c-a925-ff23d441ad0c","evidence_kind":"source_excerpt","locator":"Lines 747-758","start_line":747,"end_line":758,"excerpt":"### melatonin-smoking-endogenous-null\nEndogenous overnight melatonin AUC was similar during smoking and after abstinence.\nCondition category: normal\nnutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The supplement result cannot be generalized to the natural night signal.\norganism: Eight habitual smokers\ntissue_or_cell_type: Endogenous night secretion versus exogenous exposure\nexperimental_model: Within-person smoking versus seven-day abstinence study\nlimitations: High pharmacological dose and small cohort. Smoking affected exogenous exposure without a significant endogenous nighttime AUC change; do not conflate the two.\nexposure: 25 mg oral melatonin after nighttime sampling\nevidence_span: {\"source_cache\": \"artifacts/melatonin-research/15824912.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"c9b44dc6db12d52916bdcf69db0dd31eec1107fa54539057ea07346f1e69894c\", \"start_char\": 0, \"end_char\": 1764, \"text_sha256\": \"c9b44dc6db12d52916bdcf69db0dd31eec1107fa54539057ea07346f1e69894c\"}\n[melatonin-p15824912] Influence of cigarette smoking on melatonin levels in man. (2005). https://pubmed.ncbi.nlm.nih.gov/15824912/ DOI: 10.1007/s00228-005-0908-7","model_system":"Within-person smoking versus seven-day abstinence study","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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