Component

Abstinence from cigarette smoking

Abstinence from cigarette smoking. Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Oral melatonin AUC was higher after seven days of smoking abstinence than during smoking.

    Abstinence from cigarette smoking → Circulating melatonin exposure, route and timing specified source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/melatonin-research/15824912.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c9b44dc6db12d52916bdcf69db0dd31eec1107fa54539057ea07346f1e69894c", "start_char": 0, "end_char": 1764, "text_sha256": "c9b44dc6db12d52916bdcf69db0dd31eec1107fa54539057ea07346f1e69894c"}
    experimental_model
    Within-person smoking versus seven-day abstinence study
    exposure
    25 mg oral melatonin after nighttime sampling
    limitations
    High pharmacological dose and small cohort. Smoking affected exogenous exposure without a significant endogenous nighttime AUC change; do not conflate the two.
    nutrient_topic
    Melatonin research collection; topical membership is not evidence of a direct dietary effect. · Melatonin
    organism
    Eight habitual smokers
    plain_language
    Stopping an enzyme-inducing exposure can change supplemental melatonin pharmacokinetics.
    primary_references
    [melatonin-p15824912] Influence of cigarette smoking on melatonin levels in man. (2005). https://pubmed.ncbi.nlm.nih.gov/15824912/ DOI: 10.1007/s00228-005-0908-7
    tissue_or_cell_type
    Endogenous night secretion versus exogenous exposure

    Melatonin: synthesis, receptors, circadian timing and nutrient interactions (2026-09-17) · lines 734–745

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Within-person smoking versus seven-day abstinence study · source_derived_draft · unverified_draft

    ### melatonin-smoking-abstinence-exposure Oral melatonin AUC was higher after seven days of smoking abstinence than during smoking. Condition category: normal nutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Stopping an enzyme-inducing exposure can change supplemental melatonin pharmacokinetics. organism: Eight habitual smokers tissue_or_cell_type: Endogenous night secretion versus exogenous exposure experimental_model: Within-person smoking versus seven-day abstinence study limitations: High pharmacological dose and small cohort. Smoking affected exogenous exposure without a significant endogenous nighttime AUC change; do not conflate the two. exposure: 25 mg oral melatonin after nighttime sampling evidence_span: {"source_cache": "artifacts/melatonin-research/15824912.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c9b44dc6db12d52916bdcf69db0dd31eec1107fa54539057ea07346f1e69894c", "start_char": 0, "end_char": 1764, "text_sha256": "c9b44dc6db12d52916bdcf69db0dd31eec1107fa54539057ea07346f1e69894c"} [melatonin-p15824912] Influence of cigarette smoking on melatonin levels in man. (2005). https://pubmed.ncbi.nlm.nih.gov/15824912/ DOI: 10.1007/s00228-005-0908-7
    Complete structured claim and evidence

  2. Endogenous overnight melatonin AUC was similar during smoking and after abstinence.

    Abstinence from cigarette smoking → Nocturnal circulating melatonin concentration source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/melatonin-research/15824912.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c9b44dc6db12d52916bdcf69db0dd31eec1107fa54539057ea07346f1e69894c", "start_char": 0, "end_char": 1764, "text_sha256": "c9b44dc6db12d52916bdcf69db0dd31eec1107fa54539057ea07346f1e69894c"}
    experimental_model
    Within-person smoking versus seven-day abstinence study
    exposure
    25 mg oral melatonin after nighttime sampling
    limitations
    High pharmacological dose and small cohort. Smoking affected exogenous exposure without a significant endogenous nighttime AUC change; do not conflate the two.
    nutrient_topic
    Melatonin research collection; topical membership is not evidence of a direct dietary effect. · Melatonin
    organism
    Eight habitual smokers
    plain_language
    The supplement result cannot be generalized to the natural night signal.
    primary_references
    [melatonin-p15824912] Influence of cigarette smoking on melatonin levels in man. (2005). https://pubmed.ncbi.nlm.nih.gov/15824912/ DOI: 10.1007/s00228-005-0908-7
    tissue_or_cell_type
    Endogenous night secretion versus exogenous exposure

    Melatonin: synthesis, receptors, circadian timing and nutrient interactions (2026-09-17) · lines 747–758

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Within-person smoking versus seven-day abstinence study · source_derived_draft · unverified_draft

    ### melatonin-smoking-endogenous-null Endogenous overnight melatonin AUC was similar during smoking and after abstinence. Condition category: normal nutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect. plain_language: The supplement result cannot be generalized to the natural night signal. organism: Eight habitual smokers tissue_or_cell_type: Endogenous night secretion versus exogenous exposure experimental_model: Within-person smoking versus seven-day abstinence study limitations: High pharmacological dose and small cohort. Smoking affected exogenous exposure without a significant endogenous nighttime AUC change; do not conflate the two. exposure: 25 mg oral melatonin after nighttime sampling evidence_span: {"source_cache": "artifacts/melatonin-research/15824912.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c9b44dc6db12d52916bdcf69db0dd31eec1107fa54539057ea07346f1e69894c", "start_char": 0, "end_char": 1764, "text_sha256": "c9b44dc6db12d52916bdcf69db0dd31eec1107fa54539057ea07346f1e69894c"} [melatonin-p15824912] Influence of cigarette smoking on melatonin levels in man. (2005). https://pubmed.ncbi.nlm.nih.gov/15824912/ DOI: 10.1007/s00228-005-0908-7
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards