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Smoking affected exogenous exposure without a significant endogenous nighttime AUC change; do not conflate the two.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Melatonin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"melatonin","display_name":"Melatonin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Eight habitual smokers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Stopping an enzyme-inducing exposure can change supplemental melatonin pharmacokinetics.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[melatonin-p15824912] Influence of cigarette smoking on melatonin levels in man. (2005). https://pubmed.ncbi.nlm.nih.gov/15824912/ DOI: 10.1007/s00228-005-0908-7","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Endogenous night secretion versus exogenous exposure","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c3f9f4ee-e3b8-5e19-a768-a6e57a282c93","evidence_kind":"source_excerpt","locator":"Lines 734-745","start_line":734,"end_line":745,"excerpt":"### melatonin-smoking-abstinence-exposure\nOral melatonin AUC was higher after seven days of smoking abstinence than during smoking.\nCondition category: normal\nnutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Stopping an enzyme-inducing exposure can change supplemental melatonin pharmacokinetics.\norganism: Eight habitual smokers\ntissue_or_cell_type: Endogenous night secretion versus exogenous exposure\nexperimental_model: Within-person smoking versus seven-day abstinence study\nlimitations: High pharmacological dose and small cohort. Smoking affected exogenous exposure without a significant endogenous nighttime AUC change; do not conflate the two.\nexposure: 25 mg oral melatonin after nighttime sampling\nevidence_span: {\"source_cache\": \"artifacts/melatonin-research/15824912.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"c9b44dc6db12d52916bdcf69db0dd31eec1107fa54539057ea07346f1e69894c\", \"start_char\": 0, \"end_char\": 1764, \"text_sha256\": \"c9b44dc6db12d52916bdcf69db0dd31eec1107fa54539057ea07346f1e69894c\"}\n[melatonin-p15824912] Influence of cigarette smoking on melatonin levels in man. (2005). https://pubmed.ncbi.nlm.nih.gov/15824912/ DOI: 10.1007/s00228-005-0908-7","model_system":"Within-person smoking versus seven-day abstinence study","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [melatonin-p15824912] Influence of cigarette smoking on melatonin levels in man. (2005). https://pubmed.ncbi.nlm.nih.gov/15824912/ DOI: 10.1007/s00228-005-0908-7","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"bab588de-d217-5038-9c8b-b41222eba08b","stable_key":"import-3279ff78-2460-5064-bfc0-3f2987af85a0","title":"Melatonin: synthesis, receptors, circadian timing and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"ff4f279d263f95a69da8e7e8a6c6318ab6ba1b55254dbbda1bfa9ce437e1db80","revision_id":"0318eef8-ff38-513e-8ffa-458146ca5e77","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}