Component

Light exposure during biological night

Light exposure during biological night. Species, exposure and limitations are retained in each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Light during usual sleep hours suppressed melatonin by more than 50% in most trials.

    Light exposure during biological night → Nocturnal circulating melatonin concentration source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    biomarker_context Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/melatonin-research/21193540.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "899cae7b15ef3be8a3d4660202e8f675722295da9cb69a0eef3bdcf2470aeb23", "start_char": 0, "end_char": 1666, "text_sha256": "899cae7b15ef3be8a3d4660202e8f675722295da9cb69a0eef3bdcf2470aeb23"}
    experimental_model
    Controlled-light profiles analyzed retrospectively
    exposure
    Room light below 200 lux versus dim light below 3 lux before bed; light during usual sleep hours
    limitations
    Study light conditions are not universal thresholds for all eyes, spectra or exposure durations. Suppression is not dietary deficiency.
    nutrient_topic
    Melatonin research collection; topical membership is not evidence of a direct dietary effect. · Melatonin
    organism
    116 healthy adults aged 18-30
    plain_language
    A low sample can have an environmental explanation.
    primary_references
    [melatonin-p21193540] Exposure to room light before bedtime suppresses melatonin onset and shortens melatonin duration in humans. (2011). https://pubmed.ncbi.nlm.nih.gov/21193540/ DOI: 10.1210/jc.2010-2098
    tissue_or_cell_type
    Circulating melatonin under different light conditions
    trigger_kind
    biomarker_context Imported condition classification; unverified.

    Melatonin: synthesis, receptors, circadian timing and nutrient interactions (2026-09-17) · lines 903–914

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Controlled-light profiles analyzed retrospectively · source_derived_draft · unverified_draft

    ### melatonin-light-night-level Light during usual sleep hours suppressed melatonin by more than 50% in most trials. Condition category: biomarker_context nutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect. plain_language: A low sample can have an environmental explanation. organism: 116 healthy adults aged 18-30 tissue_or_cell_type: Circulating melatonin under different light conditions experimental_model: Controlled-light profiles analyzed retrospectively limitations: Study light conditions are not universal thresholds for all eyes, spectra or exposure durations. Suppression is not dietary deficiency. exposure: Room light below 200 lux versus dim light below 3 lux before bed; light during usual sleep hours evidence_span: {"source_cache": "artifacts/melatonin-research/21193540.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "899cae7b15ef3be8a3d4660202e8f675722295da9cb69a0eef3bdcf2470aeb23", "start_char": 0, "end_char": 1666, "text_sha256": "899cae7b15ef3be8a3d4660202e8f675722295da9cb69a0eef3bdcf2470aeb23"} [melatonin-p21193540] Exposure to room light before bedtime suppresses melatonin onset and shortens melatonin duration in humans. (2011). https://pubmed.ncbi.nlm.nih.gov/21193540/ DOI: 10.1210/jc.2010-2098
    Complete structured claim and evidence

  2. Nighttime light exposure decreased ovine AANAT Ser205 phosphorylation.

    Light exposure during biological night → Sheep AANAT Ser205 phosphorylation source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/melatonin-research/15644438.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d8be6407faaad634dbbe950dcc278cfcbe12aa24c08caafcc0ff740e8945b552", "start_char": 0, "end_char": 1693, "text_sha256": "d8be6407faaad634dbbe950dcc278cfcbe12aa24c08caafcc0ff740e8945b552"}
    experimental_model
    Phosphorylation, binding and enzyme-kinetic experiments
    exposure
    Thr31 and Ser205 phosphorylation; night versus light exposure
    limitations
    Residue numbering and kinetic states refer to ovine enzyme. Two-site and one-site binding have different effects; not a universal activation rule for all phosphorylation.
    nutrient_topic
    Melatonin research collection; topical membership is not evidence of a direct dietary effect. · Melatonin
    organism
    Sheep AANAT and 14-3-3 biochemical systems
    plain_language
    Light can alter the enzyme-regulation state, not merely the amount of starting amino acid.
    primary_references
    [melatonin-p15644438] Melatonin synthesis: 14-3-3-dependent activation and inhibition of arylalkylamine N-acetyltransferase mediated by phosphoserine-205. (2005). https://pubmed.ncbi.nlm.nih.gov/15644438/ DOI: 10.1073/pnas.0406871102
    tissue_or_cell_type
    Pineal enzyme regulation

    Melatonin: synthesis, receptors, circadian timing and nutrient interactions (2026-09-17) · lines 279–290

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Phosphorylation, binding and enzyme-kinetic experiments · source_derived_draft · unverified_draft

    ### melatonin-night-light-s205 Nighttime light exposure decreased ovine AANAT Ser205 phosphorylation. Condition category: normal nutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Light can alter the enzyme-regulation state, not merely the amount of starting amino acid. organism: Sheep AANAT and 14-3-3 biochemical systems tissue_or_cell_type: Pineal enzyme regulation experimental_model: Phosphorylation, binding and enzyme-kinetic experiments limitations: Residue numbering and kinetic states refer to ovine enzyme. Two-site and one-site binding have different effects; not a universal activation rule for all phosphorylation. exposure: Thr31 and Ser205 phosphorylation; night versus light exposure evidence_span: {"source_cache": "artifacts/melatonin-research/15644438.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d8be6407faaad634dbbe950dcc278cfcbe12aa24c08caafcc0ff740e8945b552", "start_char": 0, "end_char": 1693, "text_sha256": "d8be6407faaad634dbbe950dcc278cfcbe12aa24c08caafcc0ff740e8945b552"} [melatonin-p15644438] Melatonin synthesis: 14-3-3-dependent activation and inhibition of arylalkylamine N-acetyltransferase mediated by phosphoserine-205. (2005). https://pubmed.ncbi.nlm.nih.gov/15644438/ DOI: 10.1073/pnas.0406871102
    Complete structured claim and evidence

  3. Nighttime light exposure decreased ovine AANAT Thr31 phosphorylation.

    Light exposure during biological night → Sheep AANAT Thr31 phosphorylation source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/melatonin-research/15644438.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d8be6407faaad634dbbe950dcc278cfcbe12aa24c08caafcc0ff740e8945b552", "start_char": 0, "end_char": 1693, "text_sha256": "d8be6407faaad634dbbe950dcc278cfcbe12aa24c08caafcc0ff740e8945b552"}
    experimental_model
    Phosphorylation, binding and enzyme-kinetic experiments
    exposure
    Thr31 and Ser205 phosphorylation; night versus light exposure
    limitations
    Residue numbering and kinetic states refer to ovine enzyme. Two-site and one-site binding have different effects; not a universal activation rule for all phosphorylation.
    nutrient_topic
    Melatonin research collection; topical membership is not evidence of a direct dietary effect. · Melatonin
    organism
    Sheep AANAT and 14-3-3 biochemical systems
    plain_language
    Light can alter the enzyme-regulation state, not merely the amount of starting amino acid.
    primary_references
    [melatonin-p15644438] Melatonin synthesis: 14-3-3-dependent activation and inhibition of arylalkylamine N-acetyltransferase mediated by phosphoserine-205. (2005). https://pubmed.ncbi.nlm.nih.gov/15644438/ DOI: 10.1073/pnas.0406871102
    tissue_or_cell_type
    Pineal enzyme regulation

    Melatonin: synthesis, receptors, circadian timing and nutrient interactions (2026-09-17) · lines 266–277

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Phosphorylation, binding and enzyme-kinetic experiments · source_derived_draft · unverified_draft

    ### melatonin-night-light-t31 Nighttime light exposure decreased ovine AANAT Thr31 phosphorylation. Condition category: normal nutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Light can alter the enzyme-regulation state, not merely the amount of starting amino acid. organism: Sheep AANAT and 14-3-3 biochemical systems tissue_or_cell_type: Pineal enzyme regulation experimental_model: Phosphorylation, binding and enzyme-kinetic experiments limitations: Residue numbering and kinetic states refer to ovine enzyme. Two-site and one-site binding have different effects; not a universal activation rule for all phosphorylation. exposure: Thr31 and Ser205 phosphorylation; night versus light exposure evidence_span: {"source_cache": "artifacts/melatonin-research/15644438.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d8be6407faaad634dbbe950dcc278cfcbe12aa24c08caafcc0ff740e8945b552", "start_char": 0, "end_char": 1693, "text_sha256": "d8be6407faaad634dbbe950dcc278cfcbe12aa24c08caafcc0ff740e8945b552"} [melatonin-p15644438] Melatonin synthesis: 14-3-3-dependent activation and inhibition of arylalkylamine N-acetyltransferase mediated by phosphoserine-205. (2005). https://pubmed.ncbi.nlm.nih.gov/15644438/ DOI: 10.1073/pnas.0406871102
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards