Component
Sheep AANAT Ser205 phosphorylation
Sheep AANAT Ser205 phosphorylation. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Nighttime light exposure decreased ovine AANAT Ser205 phosphorylation.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/melatonin-research/15644438.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d8be6407faaad634dbbe950dcc278cfcbe12aa24c08caafcc0ff740e8945b552", "start_char": 0, "end_char": 1693, "text_sha256": "d8be6407faaad634dbbe950dcc278cfcbe12aa24c08caafcc0ff740e8945b552"}
- experimental_model
- Phosphorylation, binding and enzyme-kinetic experiments
- exposure
- Thr31 and Ser205 phosphorylation; night versus light exposure
- limitations
- Residue numbering and kinetic states refer to ovine enzyme. Two-site and one-site binding have different effects; not a universal activation rule for all phosphorylation.
- nutrient_topic
- Melatonin research collection; topical membership is not evidence of a direct dietary effect. · Melatonin
- organism
- Sheep AANAT and 14-3-3 biochemical systems
- plain_language
- Light can alter the enzyme-regulation state, not merely the amount of starting amino acid.
- primary_references
- [melatonin-p15644438] Melatonin synthesis: 14-3-3-dependent activation and inhibition of arylalkylamine N-acetyltransferase mediated by phosphoserine-205. (2005). https://pubmed.ncbi.nlm.nih.gov/15644438/ DOI: 10.1073/pnas.0406871102
- tissue_or_cell_type
- Pineal enzyme regulation
Melatonin: synthesis, receptors, circadian timing and nutrient interactions (2026-09-17) · lines 279–290
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Phosphorylation, binding and enzyme-kinetic experiments · source_derived_draft · unverified_draft
### melatonin-night-light-s205 Nighttime light exposure decreased ovine AANAT Ser205 phosphorylation. Condition category: normal nutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Light can alter the enzyme-regulation state, not merely the amount of starting amino acid. organism: Sheep AANAT and 14-3-3 biochemical systems tissue_or_cell_type: Pineal enzyme regulation experimental_model: Phosphorylation, binding and enzyme-kinetic experiments limitations: Residue numbering and kinetic states refer to ovine enzyme. Two-site and one-site binding have different effects; not a universal activation rule for all phosphorylation. exposure: Thr31 and Ser205 phosphorylation; night versus light exposure evidence_span: {"source_cache": "artifacts/melatonin-research/15644438.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d8be6407faaad634dbbe950dcc278cfcbe12aa24c08caafcc0ff740e8945b552", "start_char": 0, "end_char": 1693, "text_sha256": "d8be6407faaad634dbbe950dcc278cfcbe12aa24c08caafcc0ff740e8945b552"} [melatonin-p15644438] Melatonin synthesis: 14-3-3-dependent activation and inhibition of arylalkylamine N-acetyltransferase mediated by phosphoserine-205. (2005). https://pubmed.ncbi.nlm.nih.gov/15644438/ DOI: 10.1073/pnas.0406871102
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.