Component

Mouse heme oxygenase 1 / Hmox1

Mouse heme oxygenase 1 / Hmox1. Species, exposure and limitations are retained in each linked claim.

7 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. HO-1 inhibition, knockdown or genetic absence blocked the enhancement of macrophage phagocytosis by taurine chloramine, while overexpression augmented it.

    Mouse heme oxygenase 1 / Hmox1 → Taurine-chloramine-induced mouse macrophage phagocytosis source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Mouse macrophage pharmacological and genetic comparisons.
    limitations
    The mechanism concerns this phagocytosis assay, not all actions of taurine chloramine.
    nutrient_topic
    Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Taurine
    plain_language
    Removing HO-1 tested whether the observed effect needed that enzyme.
    primary_references
    Role of heme oxygenase-1 in potentiation of phagocytic activity of macrophages by taurine chloramine: Implications for the resolution of zymosan A-induced murine peritonitis. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29477410/ · DOI 10.1016/j.cellimm.2018.02.003

    Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19) · lines 393–399

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Mouse macrophage pharmacological and genetic comparisons. · source_derived_draft · unverified_draft

    ## taurine-ho1-required Removing HO-1 tested whether the observed effect needed that enzyme. HO-1 inhibition, knockdown or genetic absence blocked the enhancement of macrophage phagocytosis by taurine chloramine, while overexpression augmented it. Model: Mouse macrophage pharmacological and genetic comparisons. Limitations: The mechanism concerns this phagocytosis assay, not all actions of taurine chloramine. Evidence access: Primary abstract Role of heme oxygenase-1 in potentiation of phagocytic activity of macrophages by taurine chloramine: Implications for the resolution of zymosan A-induced murine peritonitis. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29477410/ · DOI 10.1016/j.cellimm.2018.02.003
    Complete structured claim and evidence

What acts on it

  1. DIM increased HO-1 mRNA and protein in the mouse fibroblast study.

    3,3'-Diindolylmethane / DIM → Mouse heme oxygenase 1 / Hmox1 source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/dim-research/21615272.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1ae26f09db419c2cd095519c3326616a14343b52e23a71e7994a4aed764ab1b8", "start_char": 0, "end_char": 737, "text_sha256": "1ae26f09db419c2cd095519c3326616a14343b52e23a71e7994a4aed764ab1b8"}
    experimental_model
    Reporter and gene/protein expression experiments
    exposure
    DIM compared with I3C and sulforaphane
    limitations
    Mouse cells; transcriptional induction does not establish clinical antioxidant benefit or nutrient repletion.
    nutrient_topic
    Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect. · 3,3'-Diindolylmethane / DIM
    organism
    Mouse NIH3T3 fibroblasts
    plain_language
    This downstream enzyme is recorded separately from the Nrf2 regulator.
    primary_references
    [dim-p21615272] 3,3'-Diindolylmethane but not indole-3-carbinol activates Nrf2 and induces Nrf2 target gene expression in cultured murine fibroblasts. (2011). https://pubmed.ncbi.nlm.nih.gov/21615272/ DOI: 10.3109/10715762.2011.571683
    tissue_or_cell_type
    Nrf2-regulated defense genes

    Diindolylmethane (DIM): formation, receptor signaling, metabolism and drug interactions (2026-09-17) · lines 1247–1258

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Reporter and gene/protein expression experiments · source_derived_draft · unverified_draft

    ### dim-nrf2-mouse-hmox1 DIM increased HO-1 mRNA and protein in the mouse fibroblast study. Condition category: normal nutrient_topic: Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect. plain_language: This downstream enzyme is recorded separately from the Nrf2 regulator. organism: Mouse NIH3T3 fibroblasts tissue_or_cell_type: Nrf2-regulated defense genes experimental_model: Reporter and gene/protein expression experiments limitations: Mouse cells; transcriptional induction does not establish clinical antioxidant benefit or nutrient repletion. exposure: DIM compared with I3C and sulforaphane evidence_span: {"source_cache": "artifacts/dim-research/21615272.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1ae26f09db419c2cd095519c3326616a14343b52e23a71e7994a4aed764ab1b8", "start_char": 0, "end_char": 737, "text_sha256": "1ae26f09db419c2cd095519c3326616a14343b52e23a71e7994a4aed764ab1b8"} [dim-p21615272] 3,3'-Diindolylmethane but not indole-3-carbinol activates Nrf2 and induces Nrf2 target gene expression in cultured murine fibroblasts. (2011). https://pubmed.ncbi.nlm.nih.gov/21615272/ DOI: 10.3109/10715762.2011.571683
    Complete structured claim and evidence

  2. Taurine chloramine treatment increased HO-1 expression in mouse peritoneal macrophages in the zymosan inflammation study.

    Taurine chloramine / TauCl → Mouse heme oxygenase 1 / Hmox1 source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Murine peritonitis, isolated macrophages and RAW264.7 cells.
    limitations
    This is a derivative and mouse immune-cell result, not evidence that taurine directly supplies or removes iron.
    nutrient_topic
    Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Taurine
    plain_language
    The derivative changed an enzyme involved in stress responses.
    primary_references
    Role of heme oxygenase-1 in potentiation of phagocytic activity of macrophages by taurine chloramine: Implications for the resolution of zymosan A-induced murine peritonitis. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29477410/ · DOI 10.1016/j.cellimm.2018.02.003

    Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19) · lines 385–391

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Murine peritonitis, isolated macrophages and RAW264.7 cells. · source_derived_draft · unverified_draft

    ## taurine-taucl-ho1 The derivative changed an enzyme involved in stress responses. Taurine chloramine treatment increased HO-1 expression in mouse peritoneal macrophages in the zymosan inflammation study. Model: Murine peritonitis, isolated macrophages and RAW264.7 cells. Limitations: This is a derivative and mouse immune-cell result, not evidence that taurine directly supplies or removes iron. Evidence access: Primary abstract Role of heme oxygenase-1 in potentiation of phagocytic activity of macrophages by taurine chloramine: Implications for the resolution of zymosan A-induced murine peritonitis. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29477410/ · DOI 10.1016/j.cellimm.2018.02.003
    Complete structured claim and evidence

  3. Curcumin induced HO-1 expression in JB6 cells.

    Curcumin → Mouse heme oxygenase 1 / Hmox1 source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/curcumin-research/31972171.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0a05e877dfe677824dea390c30634719eba641ed122c2480147ce2e73bf05936", "start_char": 0, "end_char": 1591, "text_sha256": "0a05e877dfe677824dea390c30634719eba641ed122c2480147ce2e73bf05936"}
    experimental_model
    Mouse epidermal-cell and skin experiments, siRNA and receptor-construct assays
    exposure
    Curcumin versus tetrahydrocurcumin; Nrf2 siRNA and Keap1 C151S construct
    limitations
    Cell exposures and construct-origin details are not available in the indexed abstract. Results do not establish human systemic target engagement.
    nutrient_topic
    Curcumin research collection; topical membership is not evidence of a direct dietary effect. · Curcumin
    organism
    Mus musculus; transfected construct species not resolved in indexed abstract
    plain_language
    The stress-response pathway increased a heme-processing enzyme.
    primary_references
    [curcumin-p31972171] Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification. (2020). https://pubmed.ncbi.nlm.nih.gov/31972171/ DOI: 10.1016/j.bcp.2020.113820
    tissue_or_cell_type
    JB6 epidermal cells and mouse skin

    Curcumin: metabolism, signaling and nutrient connections (2026-09-17) · lines 372–383

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mouse epidermal-cell and skin experiments, siRNA and receptor-construct assays · source_derived_draft · unverified_draft

    ### curcumin-ho1 Curcumin induced HO-1 expression in JB6 cells. Condition category: normal nutrient_topic: Curcumin research collection; topical membership is not evidence of a direct dietary effect. plain_language: The stress-response pathway increased a heme-processing enzyme. organism: Mus musculus; transfected construct species not resolved in indexed abstract tissue_or_cell_type: JB6 epidermal cells and mouse skin experimental_model: Mouse epidermal-cell and skin experiments, siRNA and receptor-construct assays limitations: Cell exposures and construct-origin details are not available in the indexed abstract. Results do not establish human systemic target engagement. exposure: Curcumin versus tetrahydrocurcumin; Nrf2 siRNA and Keap1 C151S construct evidence_span: {"source_cache": "artifacts/curcumin-research/31972171.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0a05e877dfe677824dea390c30634719eba641ed122c2480147ce2e73bf05936", "start_char": 0, "end_char": 1591, "text_sha256": "0a05e877dfe677824dea390c30634719eba641ed122c2480147ce2e73bf05936"} [curcumin-p31972171] Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification. (2020). https://pubmed.ncbi.nlm.nih.gov/31972171/ DOI: 10.1016/j.bcp.2020.113820
    Complete structured claim and evidence

  4. Nrf2 siRNA abrogated curcumin-induced HO-1 expression.

    Experimental mouse Nrf2 siRNA suppression → Mouse heme oxygenase 1 / Hmox1 source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/curcumin-research/31972171.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0a05e877dfe677824dea390c30634719eba641ed122c2480147ce2e73bf05936", "start_char": 0, "end_char": 1591, "text_sha256": "0a05e877dfe677824dea390c30634719eba641ed122c2480147ce2e73bf05936"}
    experimental_model
    Mouse epidermal-cell and skin experiments, siRNA and receptor-construct assays
    exposure
    Curcumin versus tetrahydrocurcumin; Nrf2 siRNA and Keap1 C151S construct
    limitations
    Cell exposures and construct-origin details are not available in the indexed abstract. Results do not establish human systemic target engagement.
    nutrient_topic
    Curcumin research collection; topical membership is not evidence of a direct dietary effect. · Curcumin
    organism
    Mus musculus; transfected construct species not resolved in indexed abstract
    plain_language
    This response required functioning Nrf2 machinery.
    primary_references
    [curcumin-p31972171] Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification. (2020). https://pubmed.ncbi.nlm.nih.gov/31972171/ DOI: 10.1016/j.bcp.2020.113820
    tissue_or_cell_type
    JB6 epidermal cells and mouse skin
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Curcumin: metabolism, signaling and nutrient connections (2026-09-17) · lines 411–422

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mouse epidermal-cell and skin experiments, siRNA and receptor-construct assays · source_derived_draft · unverified_draft

    ### curcumin-nrf2-loss Nrf2 siRNA abrogated curcumin-induced HO-1 expression. Condition category: machinery_impairment nutrient_topic: Curcumin research collection; topical membership is not evidence of a direct dietary effect. plain_language: This response required functioning Nrf2 machinery. organism: Mus musculus; transfected construct species not resolved in indexed abstract tissue_or_cell_type: JB6 epidermal cells and mouse skin experimental_model: Mouse epidermal-cell and skin experiments, siRNA and receptor-construct assays limitations: Cell exposures and construct-origin details are not available in the indexed abstract. Results do not establish human systemic target engagement. exposure: Curcumin versus tetrahydrocurcumin; Nrf2 siRNA and Keap1 C151S construct evidence_span: {"source_cache": "artifacts/curcumin-research/31972171.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0a05e877dfe677824dea390c30634719eba641ed122c2480147ce2e73bf05936", "start_char": 0, "end_char": 1591, "text_sha256": "0a05e877dfe677824dea390c30634719eba641ed122c2480147ce2e73bf05936"} [curcumin-p31972171] Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification. (2020). https://pubmed.ncbi.nlm.nih.gov/31972171/ DOI: 10.1016/j.bcp.2020.113820
    Complete structured claim and evidence

  5. Tetrahydrocurcumin failed to reproduce HO-1 induction in this comparison.

    Tetrahydrocurcumin → Mouse heme oxygenase 1 / Hmox1 source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/curcumin-research/31972171.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0a05e877dfe677824dea390c30634719eba641ed122c2480147ce2e73bf05936", "start_char": 0, "end_char": 1591, "text_sha256": "0a05e877dfe677824dea390c30634719eba641ed122c2480147ce2e73bf05936"}
    experimental_model
    Mouse epidermal-cell and skin experiments, siRNA and receptor-construct assays
    exposure
    Curcumin versus tetrahydrocurcumin; Nrf2 siRNA and Keap1 C151S construct
    limitations
    Cell exposures and construct-origin details are not available in the indexed abstract. Results do not establish human systemic target engagement.
    nutrient_topic
    Curcumin research collection; topical membership is not evidence of a direct dietary effect. · Curcumin
    organism
    Mus musculus; transfected construct species not resolved in indexed abstract
    plain_language
    The reduced metabolite did not behave like the parent compound here.
    primary_references
    [curcumin-p31972171] Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification. (2020). https://pubmed.ncbi.nlm.nih.gov/31972171/ DOI: 10.1016/j.bcp.2020.113820
    tissue_or_cell_type
    JB6 epidermal cells and mouse skin

    Curcumin: metabolism, signaling and nutrient connections (2026-09-17) · lines 398–409

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mouse epidermal-cell and skin experiments, siRNA and receptor-construct assays · source_derived_draft · unverified_draft

    ### curcumin-thc-ho1-null Tetrahydrocurcumin failed to reproduce HO-1 induction in this comparison. Condition category: normal nutrient_topic: Curcumin research collection; topical membership is not evidence of a direct dietary effect. plain_language: The reduced metabolite did not behave like the parent compound here. organism: Mus musculus; transfected construct species not resolved in indexed abstract tissue_or_cell_type: JB6 epidermal cells and mouse skin experimental_model: Mouse epidermal-cell and skin experiments, siRNA and receptor-construct assays limitations: Cell exposures and construct-origin details are not available in the indexed abstract. Results do not establish human systemic target engagement. exposure: Curcumin versus tetrahydrocurcumin; Nrf2 siRNA and Keap1 C151S construct evidence_span: {"source_cache": "artifacts/curcumin-research/31972171.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0a05e877dfe677824dea390c30634719eba641ed122c2480147ce2e73bf05936", "start_char": 0, "end_char": 1591, "text_sha256": "0a05e877dfe677824dea390c30634719eba641ed122c2480147ce2e73bf05936"} [curcumin-p31972171] Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification. (2020). https://pubmed.ncbi.nlm.nih.gov/31972171/ DOI: 10.1016/j.bcp.2020.113820
    Complete structured claim and evidence

  6. Myricetin increased hepatic HO-1 expression in the LPS/D-galactosamine mouse model.

    Myricetin → Mouse heme oxygenase 1 / Hmox1 source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Mouse liver-injury experiment.
    limitations
    Expression is not proof of direct binding or enzyme flux; accessed in-vitro knockout details do not resolve cell species.
    nutrient_topic
    Myricetin collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Myricetin
    plain_language
    A downstream defense enzyme also changed.
    primary_references
    The hepatoprotective effect of myricetin against lipopolysaccharide and D-galactosamine-induced fulminant hepatitis. · 2020 · https://pubmed.ncbi.nlm.nih.gov/31712142/ · DOI 10.1016/j.ijbiomac.2019.11.075

    Myricetin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19) · lines 644–650

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Mouse liver-injury experiment. · source_derived_draft · unverified_draft

    ## myricetin-mouse-ho1 A downstream defense enzyme also changed. Myricetin increased hepatic HO-1 expression in the LPS/D-galactosamine mouse model. Model: Mouse liver-injury experiment. Limitations: Expression is not proof of direct binding or enzyme flux; accessed in-vitro knockout details do not resolve cell species. Evidence access: Primary abstract The hepatoprotective effect of myricetin against lipopolysaccharide and D-galactosamine-induced fulminant hepatitis. · 2020 · https://pubmed.ncbi.nlm.nih.gov/31712142/ · DOI 10.1016/j.ijbiomac.2019.11.075
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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