Component

Tetrahydrocurcumin

Tetrahydrocurcumin. Species, exposure and limitations are retained in each linked claim.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Tetrahydrocurcumin failed to reproduce HO-1 induction in this comparison.

    Tetrahydrocurcumin → Mouse heme oxygenase 1 / Hmox1 source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/curcumin-research/31972171.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0a05e877dfe677824dea390c30634719eba641ed122c2480147ce2e73bf05936", "start_char": 0, "end_char": 1591, "text_sha256": "0a05e877dfe677824dea390c30634719eba641ed122c2480147ce2e73bf05936"}
    experimental_model
    Mouse epidermal-cell and skin experiments, siRNA and receptor-construct assays
    exposure
    Curcumin versus tetrahydrocurcumin; Nrf2 siRNA and Keap1 C151S construct
    limitations
    Cell exposures and construct-origin details are not available in the indexed abstract. Results do not establish human systemic target engagement.
    nutrient_topic
    Curcumin research collection; topical membership is not evidence of a direct dietary effect. · Curcumin
    organism
    Mus musculus; transfected construct species not resolved in indexed abstract
    plain_language
    The reduced metabolite did not behave like the parent compound here.
    primary_references
    [curcumin-p31972171] Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification. (2020). https://pubmed.ncbi.nlm.nih.gov/31972171/ DOI: 10.1016/j.bcp.2020.113820
    tissue_or_cell_type
    JB6 epidermal cells and mouse skin

    Curcumin: metabolism, signaling and nutrient connections (2026-09-17) · lines 398–409

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mouse epidermal-cell and skin experiments, siRNA and receptor-construct assays · source_derived_draft · unverified_draft

    ### curcumin-thc-ho1-null Tetrahydrocurcumin failed to reproduce HO-1 induction in this comparison. Condition category: normal nutrient_topic: Curcumin research collection; topical membership is not evidence of a direct dietary effect. plain_language: The reduced metabolite did not behave like the parent compound here. organism: Mus musculus; transfected construct species not resolved in indexed abstract tissue_or_cell_type: JB6 epidermal cells and mouse skin experimental_model: Mouse epidermal-cell and skin experiments, siRNA and receptor-construct assays limitations: Cell exposures and construct-origin details are not available in the indexed abstract. Results do not establish human systemic target engagement. exposure: Curcumin versus tetrahydrocurcumin; Nrf2 siRNA and Keap1 C151S construct evidence_span: {"source_cache": "artifacts/curcumin-research/31972171.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0a05e877dfe677824dea390c30634719eba641ed122c2480147ce2e73bf05936", "start_char": 0, "end_char": 1591, "text_sha256": "0a05e877dfe677824dea390c30634719eba641ed122c2480147ce2e73bf05936"} [curcumin-p31972171] Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification. (2020). https://pubmed.ncbi.nlm.nih.gov/31972171/ DOI: 10.1016/j.bcp.2020.113820
    Complete structured claim and evidence

What acts on it

  1. CurA then reduced dihydrocurcumin to tetrahydrocurcumin.

    Escherichia coli CurA, NADPH-dependent curcumin reductase → Tetrahydrocurcumin source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/curcumin-research/21467222.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c4ff0be81d2a3b3bd5edb9902da02b1e599d45a5e60ab4787514e340bf63d757", "start_char": 0, "end_char": 1325, "text_sha256": "c4ff0be81d2a3b3bd5edb9902da02b1e599d45a5e60ab4787514e340bf63d757"}
    experimental_model
    Purification and characterization of a human-fecal bacterial enzyme
    exposure
    Curcumin and reduced intermediates; NADPH-dependent reactions
    limitations
    Bacterial biochemistry does not quantify a person's circulating metabolite concentrations or establish that dietary niacin increases this conversion.
    nutrient_topic
    Curcumin research collection; topical membership is not evidence of a direct dietary effect. · Curcumin
    organism
    Escherichia coli isolate
    plain_language
    The same enzyme can carry out the next step.
    primary_references
    [curcumin-p21467222] Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism. (2011). https://pubmed.ncbi.nlm.nih.gov/21467222/ DOI: 10.1073/pnas.1016217108
    tissue_or_cell_type
    Purified CurA

    Curcumin: metabolism, signaling and nutrient connections (2026-09-17) · lines 216–227

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Purification and characterization of a human-fecal bacterial enzyme · source_derived_draft · unverified_draft

    ### curcumin-cura-second CurA then reduced dihydrocurcumin to tetrahydrocurcumin. Condition category: normal nutrient_topic: Curcumin research collection; topical membership is not evidence of a direct dietary effect. plain_language: The same enzyme can carry out the next step. organism: Escherichia coli isolate tissue_or_cell_type: Purified CurA experimental_model: Purification and characterization of a human-fecal bacterial enzyme limitations: Bacterial biochemistry does not quantify a person's circulating metabolite concentrations or establish that dietary niacin increases this conversion. exposure: Curcumin and reduced intermediates; NADPH-dependent reactions evidence_span: {"source_cache": "artifacts/curcumin-research/21467222.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c4ff0be81d2a3b3bd5edb9902da02b1e599d45a5e60ab4787514e340bf63d757", "start_char": 0, "end_char": 1325, "text_sha256": "c4ff0be81d2a3b3bd5edb9902da02b1e599d45a5e60ab4787514e340bf63d757"} [curcumin-p21467222] Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism. (2011). https://pubmed.ncbi.nlm.nih.gov/21467222/ DOI: 10.1073/pnas.1016217108
    Complete structured claim and evidence

  2. Tetrahydrocurcumin was detected among human intestinal and hepatic cytosolic metabolites.

    Human tissue cytosolic curcumin reduction → Tetrahydrocurcumin source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/curcumin-research/11815407.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "028fbc6d7e7e728f7e52970df07c8e9b04053abe4799669798d593369d2c23b8", "start_char": 0, "end_char": 2113, "text_sha256": "028fbc6d7e7e728f7e52970df07c8e9b04053abe4799669798d593369d2c23b8"}
    experimental_model
    Human and rat tissue fractions and enzyme assays
    exposure
    Curcumin incubated with tissue fractions or purified sulfotransferases
    limitations
    Ex-vivo metabolism does not measure whole-person bioavailability. Isoforms are specified only where experimentally identified.
    nutrient_topic
    Curcumin research collection; topical membership is not evidence of a direct dietary effect. · Curcumin
    organism
    Human assays below; rat experiments not merged
    plain_language
    Reduction changes curcumin into a different molecule.
    primary_references
    [curcumin-p11815407] Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine. (2002). https://pubmed.ncbi.nlm.nih.gov/11815407/
    tissue_or_cell_type
    Intestinal and hepatic microsomes and cytosol

    Curcumin: metabolism, signaling and nutrient connections (2026-09-17) · lines 151–162

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human and rat tissue fractions and enzyme assays · source_derived_draft · unverified_draft

    ### curcumin-human-thc Tetrahydrocurcumin was detected among human intestinal and hepatic cytosolic metabolites. Condition category: normal nutrient_topic: Curcumin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Reduction changes curcumin into a different molecule. organism: Human assays below; rat experiments not merged tissue_or_cell_type: Intestinal and hepatic microsomes and cytosol experimental_model: Human and rat tissue fractions and enzyme assays limitations: Ex-vivo metabolism does not measure whole-person bioavailability. Isoforms are specified only where experimentally identified. exposure: Curcumin incubated with tissue fractions or purified sulfotransferases evidence_span: {"source_cache": "artifacts/curcumin-research/11815407.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "028fbc6d7e7e728f7e52970df07c8e9b04053abe4799669798d593369d2c23b8", "start_char": 0, "end_char": 2113, "text_sha256": "028fbc6d7e7e728f7e52970df07c8e9b04053abe4799669798d593369d2c23b8"} [curcumin-p11815407] Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine. (2002). https://pubmed.ncbi.nlm.nih.gov/11815407/
    Complete structured claim and evidence

  3. Tetrahydrocurcumin showed lower glucuronidation activity than curcumin under the tested UGT2B7 conditions.

    Human UDP-glucuronosyltransferase 2B7 / UGT2B7 → Tetrahydrocurcumin source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/curcumin-research/38522299.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "84f7b5a7112090e4cc09dfd8b0bfce03908e6dd800773861d42815d71caf261c", "start_char": 0, "end_char": 1005, "text_sha256": "84f7b5a7112090e4cc09dfd8b0bfce03908e6dd800773861d42815d71caf261c"}
    experimental_model
    Glucuronidation assays with human liver microsomes and UGT2B7
    exposure
    Curcumin compared with tetrahydrocurcumin; pH-dependent structural analysis
    limitations
    Kinetic and structural comparisons do not establish comparative clinical efficacy; docking hypotheses are not imported as proven steps.
    nutrient_topic
    Curcumin research collection; topical membership is not evidence of a direct dietary effect. · Curcumin
    organism
    Human tissue and enzyme systems
    plain_language
    The reduced metabolite is processed differently.
    primary_references
    [curcumin-p38522299] Glucuronidation dynamics of curcumin and tetrahydrocurcumin for differential structures and chemical reactivities in human liver microsome and uridine diphosphate glucuronosyltransferase 2B7. (2024). https://pubmed.ncbi.nlm.nih.gov/38522299/ DOI: 10.1016/j.foodchem.2024.138929
    tissue_or_cell_type
    Microsomes and recombinant UGT2B7

    Curcumin: metabolism, signaling and nutrient connections (2026-09-17) · lines 190–201

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Glucuronidation assays with human liver microsomes and UGT2B7 · source_derived_draft · unverified_draft

    ### curcumin-ugt2b7-thc Tetrahydrocurcumin showed lower glucuronidation activity than curcumin under the tested UGT2B7 conditions. Condition category: normal nutrient_topic: Curcumin research collection; topical membership is not evidence of a direct dietary effect. plain_language: The reduced metabolite is processed differently. organism: Human tissue and enzyme systems tissue_or_cell_type: Microsomes and recombinant UGT2B7 experimental_model: Glucuronidation assays with human liver microsomes and UGT2B7 limitations: Kinetic and structural comparisons do not establish comparative clinical efficacy; docking hypotheses are not imported as proven steps. exposure: Curcumin compared with tetrahydrocurcumin; pH-dependent structural analysis evidence_span: {"source_cache": "artifacts/curcumin-research/38522299.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "84f7b5a7112090e4cc09dfd8b0bfce03908e6dd800773861d42815d71caf261c", "start_char": 0, "end_char": 1005, "text_sha256": "84f7b5a7112090e4cc09dfd8b0bfce03908e6dd800773861d42815d71caf261c"} [curcumin-p38522299] Glucuronidation dynamics of curcumin and tetrahydrocurcumin for differential structures and chemical reactivities in human liver microsome and uridine diphosphate glucuronosyltransferase 2B7. (2024). https://pubmed.ncbi.nlm.nih.gov/38522299/ DOI: 10.1016/j.foodchem.2024.138929
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards