Component

Escherichia coli CurA, NADPH-dependent curcumin reductase

Escherichia coli CurA, NADPH-dependent curcumin reductase. Species, exposure and limitations are retained in each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. CurA catalyzed the first reduction of curcumin to dihydrocurcumin.

    Escherichia coli CurA, NADPH-dependent curcumin reductase → Dihydrocurcumin source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/curcumin-research/21467222.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c4ff0be81d2a3b3bd5edb9902da02b1e599d45a5e60ab4787514e340bf63d757", "start_char": 0, "end_char": 1325, "text_sha256": "c4ff0be81d2a3b3bd5edb9902da02b1e599d45a5e60ab4787514e340bf63d757"}
    experimental_model
    Purification and characterization of a human-fecal bacterial enzyme
    exposure
    Curcumin and reduced intermediates; NADPH-dependent reactions
    limitations
    Bacterial biochemistry does not quantify a person's circulating metabolite concentrations or establish that dietary niacin increases this conversion.
    nutrient_topic
    Curcumin research collection; topical membership is not evidence of a direct dietary effect. · Curcumin
    organism
    Escherichia coli isolate
    plain_language
    A gut bacterial enzyme performs the first reduction step.
    primary_references
    [curcumin-p21467222] Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism. (2011). https://pubmed.ncbi.nlm.nih.gov/21467222/ DOI: 10.1073/pnas.1016217108
    tissue_or_cell_type
    Purified CurA

    Curcumin: metabolism, signaling and nutrient connections (2026-09-17) · lines 203–214

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Purification and characterization of a human-fecal bacterial enzyme · source_derived_draft · unverified_draft

    ### curcumin-cura-first CurA catalyzed the first reduction of curcumin to dihydrocurcumin. Condition category: normal nutrient_topic: Curcumin research collection; topical membership is not evidence of a direct dietary effect. plain_language: A gut bacterial enzyme performs the first reduction step. organism: Escherichia coli isolate tissue_or_cell_type: Purified CurA experimental_model: Purification and characterization of a human-fecal bacterial enzyme limitations: Bacterial biochemistry does not quantify a person's circulating metabolite concentrations or establish that dietary niacin increases this conversion. exposure: Curcumin and reduced intermediates; NADPH-dependent reactions evidence_span: {"source_cache": "artifacts/curcumin-research/21467222.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c4ff0be81d2a3b3bd5edb9902da02b1e599d45a5e60ab4787514e340bf63d757", "start_char": 0, "end_char": 1325, "text_sha256": "c4ff0be81d2a3b3bd5edb9902da02b1e599d45a5e60ab4787514e340bf63d757"} [curcumin-p21467222] Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism. (2011). https://pubmed.ncbi.nlm.nih.gov/21467222/ DOI: 10.1073/pnas.1016217108
    Complete structured claim and evidence

  2. CurA then reduced dihydrocurcumin to tetrahydrocurcumin.

    Escherichia coli CurA, NADPH-dependent curcumin reductase → Tetrahydrocurcumin source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/curcumin-research/21467222.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c4ff0be81d2a3b3bd5edb9902da02b1e599d45a5e60ab4787514e340bf63d757", "start_char": 0, "end_char": 1325, "text_sha256": "c4ff0be81d2a3b3bd5edb9902da02b1e599d45a5e60ab4787514e340bf63d757"}
    experimental_model
    Purification and characterization of a human-fecal bacterial enzyme
    exposure
    Curcumin and reduced intermediates; NADPH-dependent reactions
    limitations
    Bacterial biochemistry does not quantify a person's circulating metabolite concentrations or establish that dietary niacin increases this conversion.
    nutrient_topic
    Curcumin research collection; topical membership is not evidence of a direct dietary effect. · Curcumin
    organism
    Escherichia coli isolate
    plain_language
    The same enzyme can carry out the next step.
    primary_references
    [curcumin-p21467222] Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism. (2011). https://pubmed.ncbi.nlm.nih.gov/21467222/ DOI: 10.1073/pnas.1016217108
    tissue_or_cell_type
    Purified CurA

    Curcumin: metabolism, signaling and nutrient connections (2026-09-17) · lines 216–227

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Purification and characterization of a human-fecal bacterial enzyme · source_derived_draft · unverified_draft

    ### curcumin-cura-second CurA then reduced dihydrocurcumin to tetrahydrocurcumin. Condition category: normal nutrient_topic: Curcumin research collection; topical membership is not evidence of a direct dietary effect. plain_language: The same enzyme can carry out the next step. organism: Escherichia coli isolate tissue_or_cell_type: Purified CurA experimental_model: Purification and characterization of a human-fecal bacterial enzyme limitations: Bacterial biochemistry does not quantify a person's circulating metabolite concentrations or establish that dietary niacin increases this conversion. exposure: Curcumin and reduced intermediates; NADPH-dependent reactions evidence_span: {"source_cache": "artifacts/curcumin-research/21467222.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c4ff0be81d2a3b3bd5edb9902da02b1e599d45a5e60ab4787514e340bf63d757", "start_char": 0, "end_char": 1325, "text_sha256": "c4ff0be81d2a3b3bd5edb9902da02b1e599d45a5e60ab4787514e340bf63d757"} [curcumin-p21467222] Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism. (2011). https://pubmed.ncbi.nlm.nih.gov/21467222/ DOI: 10.1073/pnas.1016217108
    Complete structured claim and evidence

What acts on it

  1. The purified two-step reduction depended on NADPH.

    NADPH → Escherichia coli CurA, NADPH-dependent curcumin reductase source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/curcumin-research/21467222.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c4ff0be81d2a3b3bd5edb9902da02b1e599d45a5e60ab4787514e340bf63d757", "start_char": 0, "end_char": 1325, "text_sha256": "c4ff0be81d2a3b3bd5edb9902da02b1e599d45a5e60ab4787514e340bf63d757"}
    experimental_model
    Purification and characterization of a human-fecal bacterial enzyme
    exposure
    Curcumin and reduced intermediates; NADPH-dependent reactions
    limitations
    Bacterial biochemistry does not quantify a person's circulating metabolite concentrations or establish that dietary niacin increases this conversion.
    nutrient_topic
    Curcumin research collection; topical membership is not evidence of a direct dietary effect. · Curcumin
    organism
    Escherichia coli isolate
    plain_language
    This bacterial reaction draws on NADPH reducing power.
    primary_references
    [curcumin-p21467222] Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism. (2011). https://pubmed.ncbi.nlm.nih.gov/21467222/ DOI: 10.1073/pnas.1016217108
    tissue_or_cell_type
    Purified CurA

    Curcumin: metabolism, signaling and nutrient connections (2026-09-17) · lines 229–240

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Purification and characterization of a human-fecal bacterial enzyme · source_derived_draft · unverified_draft

    ### curcumin-cura-nadph The purified two-step reduction depended on NADPH. Condition category: normal nutrient_topic: Curcumin research collection; topical membership is not evidence of a direct dietary effect. plain_language: This bacterial reaction draws on NADPH reducing power. organism: Escherichia coli isolate tissue_or_cell_type: Purified CurA experimental_model: Purification and characterization of a human-fecal bacterial enzyme limitations: Bacterial biochemistry does not quantify a person's circulating metabolite concentrations or establish that dietary niacin increases this conversion. exposure: Curcumin and reduced intermediates; NADPH-dependent reactions evidence_span: {"source_cache": "artifacts/curcumin-research/21467222.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c4ff0be81d2a3b3bd5edb9902da02b1e599d45a5e60ab4787514e340bf63d757", "start_char": 0, "end_char": 1325, "text_sha256": "c4ff0be81d2a3b3bd5edb9902da02b1e599d45a5e60ab4787514e340bf63d757"} [curcumin-p21467222] Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism. (2011). https://pubmed.ncbi.nlm.nih.gov/21467222/ DOI: 10.1073/pnas.1016217108
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards