{"id":"cd598c7c-f651-540a-8998-a2585f8459bc","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-taucl-ho1","predicate":"induces","statement":"Taurine chloramine treatment increased HO-1 expression in mouse peritoneal macrophages in the zymosan inflammation study.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"93570d73-fa53-589e-b5be-1bdf14de67b4","mechanism_event_label":"The derivative changed an enzyme involved in stress responses.","subject":{"id":"0f99da38-0eae-53be-b1db-cb0146a11406","slug":"taurine-chloramine","display_name":"Taurine chloramine / TauCl","entity_type_key":"small_molecule"},"object":{"id":"0c325a53-28e4-529d-8322-66ba5f821c7c","slug":"mouse-hmox1","display_name":"Mouse heme oxygenase 1 / Hmox1","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"93570d73-fa53-589e-b5be-1bdf14de67b4","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-taucl-ho1-event","event_type":"observed_relationship","label":"The derivative changed an enzyme involved in stress responses.","description":"Taurine chloramine treatment increased HO-1 expression in mouse peritoneal macrophages in the zymosan inflammation study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0f99da38-0eae-53be-b1db-cb0146a11406","slug":"taurine-chloramine","display_name":"Taurine chloramine / TauCl","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0c325a53-28e4-529d-8322-66ba5f821c7c","slug":"mouse-hmox1","display_name":"Mouse heme oxygenase 1 / Hmox1","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Murine peritonitis, isolated macrophages and RAW264.7 cells.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This is a derivative and mouse immune-cell result, not evidence that taurine directly supplies or removes iron.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The derivative changed an enzyme involved in stress responses.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Role of heme oxygenase-1 in potentiation of phagocytic activity of macrophages by taurine chloramine: Implications for the resolution of zymosan A-induced murine peritonitis. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29477410/ · DOI 10.1016/j.cellimm.2018.02.003","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"3ab92f1b-d45b-5139-9386-4eec14df46d7","evidence_kind":"source_excerpt","locator":"Lines 385-391","start_line":385,"end_line":391,"excerpt":"## taurine-taucl-ho1\nThe derivative changed an enzyme involved in stress responses.\nTaurine chloramine treatment increased HO-1 expression in mouse peritoneal macrophages in the zymosan inflammation study.\nModel: Murine peritonitis, isolated macrophages and RAW264.7 cells.\nLimitations: This is a derivative and mouse immune-cell result, not evidence that taurine directly supplies or removes iron.\nEvidence access: Primary abstract\nRole of heme oxygenase-1 in potentiation of phagocytic activity of macrophages by taurine chloramine: Implications for the resolution of zymosan A-induced murine peritonitis. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29477410/ · DOI 10.1016/j.cellimm.2018.02.003","model_system":"Murine peritonitis, isolated macrophages and RAW264.7 cells.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc8d9ab8-fdf9-5107-877c-336cf8005097","stable_key":"import-1acdb1e8-2159-5c7f-b39f-0153ff8024ae","title":"Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"c6cb77619a374d9b1b04830032fdd3b33d269d160df5baba3778fad5adf57db5","revision_id":"cc45c491-cc6a-5426-ab72-d7c6d26c3614","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}