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Results do not establish human systemic target engagement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Curcumin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"curcumin","display_name":"Curcumin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Mus musculus; transfected construct species not resolved in indexed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"This response required functioning Nrf2 machinery.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[curcumin-p31972171] Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification. 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Results do not establish human systemic target engagement.\nexposure: Curcumin versus tetrahydrocurcumin; Nrf2 siRNA and Keap1 C151S construct\nevidence_span: {\"source_cache\": \"artifacts/curcumin-research/31972171.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"0a05e877dfe677824dea390c30634719eba641ed122c2480147ce2e73bf05936\", \"start_char\": 0, \"end_char\": 1591, \"text_sha256\": \"0a05e877dfe677824dea390c30634719eba641ed122c2480147ce2e73bf05936\"}\n[curcumin-p31972171] Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification. (2020). https://pubmed.ncbi.nlm.nih.gov/31972171/ DOI: 10.1016/j.bcp.2020.113820","model_system":"Mouse epidermal-cell and skin experiments, siRNA and receptor-construct assays","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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