{"id":"3643578d-a634-5061-926a-1ddabda8ff7c","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-ho1-required","predicate":"loss_blocks","statement":"HO-1 inhibition, knockdown or genetic absence blocked the enhancement of macrophage phagocytosis by taurine chloramine, while overexpression augmented it.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"cc80dc9e-3f33-558f-8517-599a279f757f","mechanism_event_label":"Removing HO-1 tested whether the observed effect needed that enzyme.","subject":{"id":"0c325a53-28e4-529d-8322-66ba5f821c7c","slug":"mouse-hmox1","display_name":"Mouse heme oxygenase 1 / Hmox1","entity_type_key":"protein"},"object":{"id":"f8edb524-af1f-5dc6-8af2-5b73a461a3fc","slug":"mouse-taucl-phagocytosis","display_name":"Taurine-chloramine-induced mouse macrophage phagocytosis","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"cc80dc9e-3f33-558f-8517-599a279f757f","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-ho1-required-event","event_type":"observed_relationship","label":"Removing HO-1 tested whether the observed effect needed that enzyme.","description":"HO-1 inhibition, knockdown or genetic absence blocked the enhancement of macrophage phagocytosis by taurine chloramine, while overexpression augmented it.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0c325a53-28e4-529d-8322-66ba5f821c7c","slug":"mouse-hmox1","display_name":"Mouse heme oxygenase 1 / Hmox1","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f8edb524-af1f-5dc6-8af2-5b73a461a3fc","slug":"mouse-taucl-phagocytosis","display_name":"Taurine-chloramine-induced mouse macrophage phagocytosis","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"0f99da38-0eae-53be-b1db-cb0146a11406","slug":"taurine-chloramine","display_name":"Taurine chloramine / TauCl","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse macrophage pharmacological and genetic comparisons.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The mechanism concerns this phagocytosis assay, not all actions of taurine chloramine.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Removing HO-1 tested whether the observed effect needed that enzyme.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Role of heme oxygenase-1 in potentiation of phagocytic activity of macrophages by taurine chloramine: Implications for the resolution of zymosan A-induced murine peritonitis. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29477410/ · DOI 10.1016/j.cellimm.2018.02.003","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"5e3bd3ae-8553-5d84-a778-2434654c2348","evidence_kind":"source_excerpt","locator":"Lines 393-399","start_line":393,"end_line":399,"excerpt":"## taurine-ho1-required\nRemoving HO-1 tested whether the observed effect needed that enzyme.\nHO-1 inhibition, knockdown or genetic absence blocked the enhancement of macrophage phagocytosis by taurine chloramine, while overexpression augmented it.\nModel: Mouse macrophage pharmacological and genetic comparisons.\nLimitations: The mechanism concerns this phagocytosis assay, not all actions of taurine chloramine.\nEvidence access: Primary abstract\nRole of heme oxygenase-1 in potentiation of phagocytic activity of macrophages by taurine chloramine: Implications for the resolution of zymosan A-induced murine peritonitis. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29477410/ · DOI 10.1016/j.cellimm.2018.02.003","model_system":"Mouse macrophage pharmacological and genetic comparisons.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc8d9ab8-fdf9-5107-877c-336cf8005097","stable_key":"import-1acdb1e8-2159-5c7f-b39f-0153ff8024ae","title":"Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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