Component

Weight loss during systemic cysteine depletion in mice

Context-specific entity; species, compartment and exposure are stated on each claim.

5 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

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What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. The study linked cysteine-depletion-induced adipose browning and weight loss to sympathetic noradrenaline signaling through beta-3 adrenergic receptors.

    Mouse beta-3 adrenergic receptor / Adrb3 → Weight loss during systemic cysteine depletion in mice source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    evidence_access
    Primary full text
    experimental_model
    Mouse systemic depletion with sympathetic and adrenergic perturbations.
    limitations
    Does not establish that cysteine directly binds the adrenergic receptor or that dietary changes reproduce the genetic model.
    nutrient_topic
    L-Cysteine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Cysteine
    plain_language
    The whole-body response involved nerve-to-fat signaling.
    primary_references
    Cysteine depletion triggers adipose tissue thermogenesis and weight loss. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40461845/ · DOI 10.1038/s42255-025-01297-8
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    L-Cysteine: sulfur allocation, redox supply and cross-nutrient mechanisms (2026-09-19) · lines 372–378

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Mouse systemic depletion with sympathetic and adrenergic perturbations. · source_derived_draft · unverified_draft

    ## l-cysteine-adrenergic-depletion-response The whole-body response involved nerve-to-fat signaling. The study linked cysteine-depletion-induced adipose browning and weight loss to sympathetic noradrenaline signaling through beta-3 adrenergic receptors. Model: Mouse systemic depletion with sympathetic and adrenergic perturbations. Limitations: Does not establish that cysteine directly binds the adrenergic receptor or that dietary changes reproduce the genetic model. Evidence access: Primary full text Cysteine depletion triggers adipose tissue thermogenesis and weight loss. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40461845/ · DOI 10.1038/s42255-025-01297-8
    Complete structured claim and evidence

  2. Fgf21 knockout attenuated weight loss in mice fed a diet lacking both methionine and cysteine.

    Mouse fibroblast growth factor 21 / Fgf21 → Weight loss during systemic cysteine depletion in mice source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    evidence_access
    Primary full text
    experimental_model
    Fgf21-null versus control mice on no-methionine/no-cysteine diets; separate from the Cse-null cysteine-only experiment.
    limitations
    Do not silently replace the combined restriction with cysteine-only restriction. Correction record: Author correction published 12 December 2025 (2026 issue), PMID 41388205, DOI 10.1038/s41586-025-09780-8: two incorrect day-3 muscle histology panels in Extended Data Fig. 2f,g duplicated day-7 panels and were replaced. The authors state that figure and paper conclusions were unaffected. This is a figure correction, not independent validation. https://www.nature.com/articles/s41586-025-09780-8
    nutrient_topic
    L-Cysteine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Cysteine
    plain_language
    A stress hormone contributed under combined sulfur-amino-acid withdrawal.
    primary_references
    Unravelling cysteine-deficiency-associated rapid weight loss. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40399674/ · DOI 10.1038/s41586-025-08996-y
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    L-Cysteine: sulfur allocation, redox supply and cross-nutrient mechanisms (2026-09-19) · lines 340–346

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Fgf21-null versus control mice on no-methionine/no-cysteine diets; separate from the Cse-null cysteine-only experiment. · source_derived_draft · unverified_draft

    ## l-cysteine-fgf21-combined-restriction A stress hormone contributed under combined sulfur-amino-acid withdrawal. Fgf21 knockout attenuated weight loss in mice fed a diet lacking both methionine and cysteine. Model: Fgf21-null versus control mice on no-methionine/no-cysteine diets; separate from the Cse-null cysteine-only experiment. Limitations: Do not silently replace the combined restriction with cysteine-only restriction. Correction record: Author correction published 12 December 2025 (2026 issue), PMID 41388205, DOI 10.1038/s41586-025-09780-8: two incorrect day-3 muscle histology panels in Extended Data Fig. 2f,g duplicated day-7 panels and were replaced. The authors state that figure and paper conclusions were unaffected. This is a figure correction, not independent validation. https://www.nature.com/articles/s41586-025-09780-8 Evidence access: Primary full text Unravelling cysteine-deficiency-associated rapid weight loss. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40399674/ · DOI 10.1038/s41586-025-08996-y
    Complete structured claim and evidence

  3. Additional Fgf21 deletion in Cth-null mice did not prevent the rapid weight-loss phenotype during cysteine-free feeding.

    Mouse fibroblast growth factor 21 / Fgf21 → Weight loss during systemic cysteine depletion in mice source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    evidence_access
    Primary full text
    experimental_model
    Cth-null versus Cth/Fgf21 double-null mice on cysteine-free diet for five days.
    limitations
    Different genotype and diet from the combined methionine/cysteine restriction study; no universal FGF21 dependence is assigned.
    nutrient_topic
    L-Cysteine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Cysteine
    plain_language
    An increased hormone level did not make that hormone necessary for this outcome.
    primary_references
    Cysteine depletion triggers adipose tissue thermogenesis and weight loss. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40461845/ · DOI 10.1038/s42255-025-01297-8
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    L-Cysteine: sulfur allocation, redox supply and cross-nutrient mechanisms (2026-09-19) · lines 364–370

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Cth-null versus Cth/Fgf21 double-null mice on cysteine-free diet for five days. · source_derived_draft · unverified_draft

    ## l-cysteine-fgf21-cysteine-only-limit An increased hormone level did not make that hormone necessary for this outcome. Additional Fgf21 deletion in Cth-null mice did not prevent the rapid weight-loss phenotype during cysteine-free feeding. Model: Cth-null versus Cth/Fgf21 double-null mice on cysteine-free diet for five days. Limitations: Different genotype and diet from the combined methionine/cysteine restriction study; no universal FGF21 dependence is assigned. Evidence access: Primary full text Cysteine depletion triggers adipose tissue thermogenesis and weight loss. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40461845/ · DOI 10.1038/s42255-025-01297-8
    Complete structured claim and evidence

  4. Whole-body Cth-null mice fed a cysteine-free diet developed rapid fat loss and adipose browning; restoring cysteine reversed the phenotype, whereas prolonged depletion could be lethal.

    Whole-body Cth loss plus cysteine-free feeding → Weight loss during systemic cysteine depletion in mice source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    evidence_access
    Primary full text
    experimental_model
    Mouse genetic/dietary depletion and repletion; lean and obese models.
    limitations
    Severe induced deficiency is not evidence for a safe human weight-loss strategy.
    nutrient_topic
    L-Cysteine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Cysteine
    plain_language
    Loss of the nutrient caused systemic stress, not simply a desirable fat-burning switch.
    primary_references
    Cysteine depletion triggers adipose tissue thermogenesis and weight loss. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40461845/ · DOI 10.1038/s42255-025-01297-8
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    L-Cysteine: sulfur allocation, redox supply and cross-nutrient mechanisms (2026-09-19) · lines 356–362

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Mouse genetic/dietary depletion and repletion; lean and obese models. · source_derived_draft · unverified_draft

    ## l-cysteine-systemic-depletion-reversal Loss of the nutrient caused systemic stress, not simply a desirable fat-burning switch. Whole-body Cth-null mice fed a cysteine-free diet developed rapid fat loss and adipose browning; restoring cysteine reversed the phenotype, whereas prolonged depletion could be lethal. Model: Mouse genetic/dietary depletion and repletion; lean and obese models. Limitations: Severe induced deficiency is not evidence for a safe human weight-loss strategy. Evidence access: Primary full text Cysteine depletion triggers adipose tissue thermogenesis and weight loss. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40461845/ · DOI 10.1038/s42255-025-01297-8
    Complete structured claim and evidence

  5. Cth/Ucp1 double-null mice still lost weight during cysteine deprivation; body-mass-adjusted energy expenditure was lower than in Cth-null mice in the reported comparison.

    Mouse uncoupling protein 1 / Ucp1 → Weight loss during systemic cysteine depletion in mice source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    evidence_access
    Primary full text
    experimental_model
    Mouse double-knockout comparisons, six-day diet and metabolic-cage analysis.
    limitations
    UCP1-independent weight loss must not be generalized to UCP1-independent heat production or identical energy expenditure.
    nutrient_topic
    L-Cysteine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Cysteine
    plain_language
    Persistence of weight loss does not mean every thermogenic measurement was unchanged.
    primary_references
    Cysteine depletion triggers adipose tissue thermogenesis and weight loss. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40461845/ · DOI 10.1038/s42255-025-01297-8
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    L-Cysteine: sulfur allocation, redox supply and cross-nutrient mechanisms (2026-09-19) · lines 380–386

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Mouse double-knockout comparisons, six-day diet and metabolic-cage analysis. · source_derived_draft · unverified_draft

    ## l-cysteine-ucp1-endpoint-limit Persistence of weight loss does not mean every thermogenic measurement was unchanged. Cth/Ucp1 double-null mice still lost weight during cysteine deprivation; body-mass-adjusted energy expenditure was lower than in Cth-null mice in the reported comparison. Model: Mouse double-knockout comparisons, six-day diet and metabolic-cage analysis. Limitations: UCP1-independent weight loss must not be generalized to UCP1-independent heat production or identical energy expenditure. Evidence access: Primary full text Cysteine depletion triggers adipose tissue thermogenesis and weight loss. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40461845/ · DOI 10.1038/s42255-025-01297-8
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

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