{"id":"e67c06bb-c7b8-55c7-80ae-7c50d51b777f","stable_key":"a8baf7e9-80e4-5d8c-adec-9a63e84d2f21:l-cysteine-ucp1-endpoint-limit","predicate":"is_not_required_for_weight_loss","statement":"Cth/Ucp1 double-null mice still lost weight during cysteine deprivation; body-mass-adjusted energy expenditure was lower than in Cth-null mice in the reported comparison.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"1257327a-ea89-5594-a682-d4bbef1c34c5","mechanism_event_label":"Persistence of weight loss does not mean every thermogenic measurement was unchanged.","subject":{"id":"70be98ea-8d3a-5c43-ab31-1b1eb695e65b","slug":"mouse-ucp1","display_name":"Mouse uncoupling protein 1 / Ucp1","entity_type_key":"protein"},"object":{"id":"ea7d72df-c02d-5680-907a-66c588e31392","slug":"mouse-cysteine-depletion-weight-loss","display_name":"Weight loss during systemic cysteine depletion in mice","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"1257327a-ea89-5594-a682-d4bbef1c34c5","stable_key":"a8baf7e9-80e4-5d8c-adec-9a63e84d2f21:l-cysteine-ucp1-endpoint-limit-event","event_type":"observed_relationship","label":"Persistence of weight loss does not mean every thermogenic measurement was unchanged.","description":"Cth/Ucp1 double-null mice still lost weight during cysteine deprivation; body-mass-adjusted energy expenditure was lower than in Cth-null mice in the reported comparison.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"70be98ea-8d3a-5c43-ab31-1b1eb695e65b","slug":"mouse-ucp1","display_name":"Mouse uncoupling protein 1 / Ucp1","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ea7d72df-c02d-5680-907a-66c588e31392","slug":"mouse-cysteine-depletion-weight-loss","display_name":"Weight loss during systemic cysteine depletion in mice","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ca899f13-50ad-55e5-ab99-329ae0038c74","slug":"l-cysteine","display_name":"L-Cysteine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"09418c83-db15-582a-92a2-7d928f3ec14a","slug":"mouse-cth","display_name":"Mouse cystathionine gamma-lyase / Cth","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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