{"id":"0c356ec6-268f-52c8-a33e-f2b0d4e99dcf","stable_key":"a8baf7e9-80e4-5d8c-adec-9a63e84d2f21:l-cysteine-adrenergic-depletion-response","predicate":"mediates_tested","statement":"The study linked cysteine-depletion-induced adipose browning and weight loss to sympathetic noradrenaline signaling through beta-3 adrenergic receptors.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d9ffe1e2-09b7-5fb0-90e6-12147e6a959a","mechanism_event_label":"The whole-body response involved nerve-to-fat signaling.","subject":{"id":"3d3ccca3-da93-5416-8397-30ad46a1d44f","slug":"mouse-adrb3","display_name":"Mouse beta-3 adrenergic receptor / Adrb3","entity_type_key":"protein"},"object":{"id":"ea7d72df-c02d-5680-907a-66c588e31392","slug":"mouse-cysteine-depletion-weight-loss","display_name":"Weight loss during systemic cysteine depletion in mice","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d9ffe1e2-09b7-5fb0-90e6-12147e6a959a","stable_key":"a8baf7e9-80e4-5d8c-adec-9a63e84d2f21:l-cysteine-adrenergic-depletion-response-event","event_type":"observed_relationship","label":"The whole-body response involved nerve-to-fat signaling.","description":"The study linked cysteine-depletion-induced adipose browning and weight loss to sympathetic noradrenaline signaling through beta-3 adrenergic receptors.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"3d3ccca3-da93-5416-8397-30ad46a1d44f","slug":"mouse-adrb3","display_name":"Mouse beta-3 adrenergic receptor / Adrb3","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ea7d72df-c02d-5680-907a-66c588e31392","slug":"mouse-cysteine-depletion-weight-loss","display_name":"Weight loss during systemic cysteine depletion in mice","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ca899f13-50ad-55e5-ab99-329ae0038c74","slug":"l-cysteine","display_name":"L-Cysteine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"09418c83-db15-582a-92a2-7d928f3ec14a","slug":"mouse-cth","display_name":"Mouse cystathionine gamma-lyase / Cth","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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