Component

Mouse uncoupling protein 1 / Ucp1

Context-specific entity; species, compartment and exposure are stated on each claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Cth/Ucp1 double-null mice still lost weight during cysteine deprivation; body-mass-adjusted energy expenditure was lower than in Cth-null mice in the reported comparison.

    Mouse uncoupling protein 1 / Ucp1 → Weight loss during systemic cysteine depletion in mice source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    evidence_access
    Primary full text
    experimental_model
    Mouse double-knockout comparisons, six-day diet and metabolic-cage analysis.
    limitations
    UCP1-independent weight loss must not be generalized to UCP1-independent heat production or identical energy expenditure.
    nutrient_topic
    L-Cysteine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Cysteine
    plain_language
    Persistence of weight loss does not mean every thermogenic measurement was unchanged.
    primary_references
    Cysteine depletion triggers adipose tissue thermogenesis and weight loss. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40461845/ · DOI 10.1038/s42255-025-01297-8
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    L-Cysteine: sulfur allocation, redox supply and cross-nutrient mechanisms (2026-09-19) · lines 380–386

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Mouse double-knockout comparisons, six-day diet and metabolic-cage analysis. · source_derived_draft · unverified_draft

    ## l-cysteine-ucp1-endpoint-limit Persistence of weight loss does not mean every thermogenic measurement was unchanged. Cth/Ucp1 double-null mice still lost weight during cysteine deprivation; body-mass-adjusted energy expenditure was lower than in Cth-null mice in the reported comparison. Model: Mouse double-knockout comparisons, six-day diet and metabolic-cage analysis. Limitations: UCP1-independent weight loss must not be generalized to UCP1-independent heat production or identical energy expenditure. Evidence access: Primary full text Cysteine depletion triggers adipose tissue thermogenesis and weight loss. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40461845/ · DOI 10.1038/s42255-025-01297-8
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. BAT-specific Slc25a44 deletion blunted BCAA oxidation and non-shivering thermogenesis following intracerebroventricular PGE2.

    Mouse mitochondrial BCAA carrier / Slc25a44 → PGE2-evoked BAT thermogenesis in mice source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_access
    Primary full text
    experimental_model
    Mouse conditional knockout; PGE2 1.4 micrograms per mouse; valine oxidation readout.
    limitations
    Not an isoleucine-specific tracer result or a supplement treatment for fever.
    nutrient_topic
    L-Isoleucine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Isoleucine
    plain_language
    The shared mitochondrial gate mattered during a defined fever response.
    primary_references
    Metabolic flexibility via mitochondrial BCAA carrier SLC25A44 is required for optimal fever. · 2021 · https://pubmed.ncbi.nlm.nih.gov/33944778/ · DOI 10.7554/eLife.66865
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    L-Isoleucine: transport, translation, catabolism and cross-nutrient mechanisms (2026-09-19) · lines 74–80

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Mouse conditional knockout; PGE2 1.4 micrograms per mouse; valine oxidation readout. · source_derived_draft · unverified_draft

    ## isoleucine-fever-carrier The shared mitochondrial gate mattered during a defined fever response. BAT-specific Slc25a44 deletion blunted BCAA oxidation and non-shivering thermogenesis following intracerebroventricular PGE2. Model: Mouse conditional knockout; PGE2 1.4 micrograms per mouse; valine oxidation readout. Limitations: Not an isoleucine-specific tracer result or a supplement treatment for fever. Evidence access: Primary full text Metabolic flexibility via mitochondrial BCAA carrier SLC25A44 is required for optimal fever. · 2021 · https://pubmed.ncbi.nlm.nih.gov/33944778/ · DOI 10.7554/eLife.66865
    Complete structured claim and evidence

  2. The reduced-isoleucine diet increased hepatic FGF21 expression and circulating FGF21, with adipose UCP1-associated changes and increased energy expenditure.

    Experimentally reduced-isoleucine mouse diet → Mouse fibroblast growth factor 21 / Fgf21 source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text
    experimental_model
    Mouse formulated-diet and tissue studies.
    limitations
    Co-change alone does not show that every metabolic benefit depends on FGF21.
    nutrient_topic
    L-Isoleucine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Isoleucine
    plain_language
    Dietary composition elicited a liver-to-adipose hormonal response.
    primary_references
    The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine. · 2021 · https://pubmed.ncbi.nlm.nih.gov/33887198/ · DOI 10.1016/j.cmet.2021.03.025

    L-Isoleucine: transport, translation, catabolism and cross-nutrient mechanisms (2026-09-19) · lines 378–384

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Mouse formulated-diet and tissue studies. · source_derived_draft · unverified_draft

    ## isoleucine-restriction-fgf21 Dietary composition elicited a liver-to-adipose hormonal response. The reduced-isoleucine diet increased hepatic FGF21 expression and circulating FGF21, with adipose UCP1-associated changes and increased energy expenditure. Model: Mouse formulated-diet and tissue studies. Limitations: Co-change alone does not show that every metabolic benefit depends on FGF21. Evidence access: Primary full text The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine. · 2021 · https://pubmed.ncbi.nlm.nih.gov/33887198/ · DOI 10.1016/j.cmet.2021.03.025
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards