Component
Mouse beta-3 adrenergic receptor / Adrb3
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
The study linked cysteine-depletion-induced adipose browning and weight loss to sympathetic noradrenaline signaling through beta-3 adrenergic receptors.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- evidence_access
- Primary full text
- experimental_model
- Mouse systemic depletion with sympathetic and adrenergic perturbations.
- limitations
- Does not establish that cysteine directly binds the adrenergic receptor or that dietary changes reproduce the genetic model.
- nutrient_topic
- L-Cysteine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Cysteine
- plain_language
- The whole-body response involved nerve-to-fat signaling.
- primary_references
- Cysteine depletion triggers adipose tissue thermogenesis and weight loss. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40461845/ · DOI 10.1038/s42255-025-01297-8
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
L-Cysteine: sulfur allocation, redox supply and cross-nutrient mechanisms (2026-09-19) · lines 372–378
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Mouse systemic depletion with sympathetic and adrenergic perturbations. · source_derived_draft · unverified_draft
## l-cysteine-adrenergic-depletion-response The whole-body response involved nerve-to-fat signaling. The study linked cysteine-depletion-induced adipose browning and weight loss to sympathetic noradrenaline signaling through beta-3 adrenergic receptors. Model: Mouse systemic depletion with sympathetic and adrenergic perturbations. Limitations: Does not establish that cysteine directly binds the adrenergic receptor or that dietary changes reproduce the genetic model. Evidence access: Primary full text Cysteine depletion triggers adipose tissue thermogenesis and weight loss. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40461845/ · DOI 10.1038/s42255-025-01297-8
Complete structured claim and evidence
Where it participates (unsigned role)
In brown adipose tissue of hypothyroid rats beta-3 adrenergic receptor number and mRNA increased 4- to 6-fold while both fell in white adipose tissue, T3 injection reverted the changes within 24 hours, and T3 excess caused a greater than 90% reduction of beta-3 receptor mRNA in brown fat but a 5-fold increase in white fat.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/cold-research/7628361.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "ee7ba7cfa7ae3387c067f33a03ad9c212801437175f6cb656d5e86b482ed8d64", "start_char": 0, "end_char": 2080, "text_sha256": "ee7ba7cfa7ae3387c067f33a03ad9c212801437175f6cb656d5e86b482ed8d64"}
- experimental_model
- Brown and white adipose tissue of hypothyroid and T3-treated rats
- exposure
- Hypothyroidism, T3 replacement and T3 excess
- limitations
- The reciprocal regulation in the two tissues is the informative part. A post-receptor cAMP defect persisted after receptor numbers were corrected, so receptor count is not the whole story.
- nutrient_topic
- Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. · Cold water immersion
- organism
- Rat
- plain_language
- Thyroid hormone tunes how loudly each fat depot hears the nerve signal, in opposite directions.
- primary_references
- [cold-p7628361] Thyroid hormone and norepinephrine signaling in brown adipose tissue. II: Differential effects of thyroid hormone on beta 3-adrenergic receptors in brown and white adipose tissue. (1995). https://pubmed.ncbi.nlm.nih.gov/7628361/ DOI: 10.1210/endo.136.8.7628361
- tissue_or_cell_type
- Brown and white adipose tissue
Cold water immersion: cold sensing, heat production, the catecholamine axis and what repeated exposure changes (2026-09-19) · lines 429–440
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Brown and white adipose tissue of hypothyroid and T3-treated rats · source_derived_draft · unverified_draft
### cold-thyroid-beta3-regulation In brown adipose tissue of hypothyroid rats beta-3 adrenergic receptor number and mRNA increased 4- to 6-fold while both fell in white adipose tissue, T3 injection reverted the changes within 24 hours, and T3 excess caused a greater than 90% reduction of beta-3 receptor mRNA in brown fat but a 5-fold increase in white fat. Condition category: normal nutrient_topic: Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. plain_language: Thyroid hormone tunes how loudly each fat depot hears the nerve signal, in opposite directions. organism: Rat tissue_or_cell_type: Brown and white adipose tissue experimental_model: Brown and white adipose tissue of hypothyroid and T3-treated rats limitations: The reciprocal regulation in the two tissues is the informative part. A post-receptor cAMP defect persisted after receptor numbers were corrected, so receptor count is not the whole story. exposure: Hypothyroidism, T3 replacement and T3 excess evidence_span: {"source_cache": "artifacts/cold-research/7628361.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "ee7ba7cfa7ae3387c067f33a03ad9c212801437175f6cb656d5e86b482ed8d64", "start_char": 0, "end_char": 2080, "text_sha256": "ee7ba7cfa7ae3387c067f33a03ad9c212801437175f6cb656d5e86b482ed8d64"} [cold-p7628361] Thyroid hormone and norepinephrine signaling in brown adipose tissue. II: Differential effects of thyroid hormone on beta 3-adrenergic receptors in brown and white adipose tissue. (1995). https://pubmed.ncbi.nlm.nih.gov/7628361/ DOI: 10.1210/endo.136.8.7628361
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.