Component
Human beta-3 adrenergic receptor / ADRB3
Human beta-3 adrenergic receptor / ADRB3. Species, exposure and limitations are retained in each linked claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
UCP1 expression could be induced by any of the beta-1, beta-2 or beta-3 adrenergic receptor subtypes, but the greatest response came from stimulating all three simultaneously, and beta-3 stimulation did not prevent norepinephrine from further raising adenylyl cyclase activity, suggesting an additive cAMP response.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/cold-research/7738011.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b1c5506f21f40d6674727a5fc3344f2b02f7fc9f2f1e911fd04bfecfc2399175", "start_char": 0, "end_char": 2592, "text_sha256": "b1c5506f21f40d6674727a5fc3344f2b02f7fc9f2f1e911fd04bfecfc2399175"}
- experimental_model
- Immortalized mouse brown adipocyte cell lines with selective beta-adrenergic agonists and antagonists
- exposure
- Norepinephrine, the beta-3 selective agonist CL316,243, and subtype-selective antagonists
- limitations
- A cell-line dissection of receptor subtypes. The additive cAMP response indicates the subtypes are not redundant, but these are immortalized cells.
- nutrient_topic
- Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. · Cold water immersion
- organism
- Mouse cell lines
- plain_language
- Three different receptors for the same messenger all feed the heat gene, and together they do more than any one alone.
- primary_references
- [cold-p7738011] Regulation of the uncoupling protein gene (Ucp) by beta 1, beta 2, and beta 3-adrenergic receptor subtypes in immortalized brown adipose cell lines. (1995). https://pubmed.ncbi.nlm.nih.gov/7738011/ DOI: 10.1074/jbc.270.18.10723
- tissue_or_cell_type
- Brown adipocytes
Cold water immersion: cold sensing, heat production, the catecholamine axis and what repeated exposure changes (2026-09-19) · lines 364–375
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Immortalized mouse brown adipocyte cell lines with selective beta-adrenergic agonists and antagonists · source_derived_draft · unverified_draft
### cold-beta-receptors-ucp1 UCP1 expression could be induced by any of the beta-1, beta-2 or beta-3 adrenergic receptor subtypes, but the greatest response came from stimulating all three simultaneously, and beta-3 stimulation did not prevent norepinephrine from further raising adenylyl cyclase activity, suggesting an additive cAMP response. Condition category: normal nutrient_topic: Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. plain_language: Three different receptors for the same messenger all feed the heat gene, and together they do more than any one alone. organism: Mouse cell lines tissue_or_cell_type: Brown adipocytes experimental_model: Immortalized mouse brown adipocyte cell lines with selective beta-adrenergic agonists and antagonists limitations: A cell-line dissection of receptor subtypes. The additive cAMP response indicates the subtypes are not redundant, but these are immortalized cells. exposure: Norepinephrine, the beta-3 selective agonist CL316,243, and subtype-selective antagonists evidence_span: {"source_cache": "artifacts/cold-research/7738011.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b1c5506f21f40d6674727a5fc3344f2b02f7fc9f2f1e911fd04bfecfc2399175", "start_char": 0, "end_char": 2592, "text_sha256": "b1c5506f21f40d6674727a5fc3344f2b02f7fc9f2f1e911fd04bfecfc2399175"} [cold-p7738011] Regulation of the uncoupling protein gene (Ucp) by beta 1, beta 2, and beta 3-adrenergic receptor subtypes in immortalized brown adipose cell lines. (1995). https://pubmed.ncbi.nlm.nih.gov/7738011/ DOI: 10.1074/jbc.270.18.10723
Complete structured claim and evidence
What acts on it
In brown adipose tissue of hypothyroid rats beta-3 adrenergic receptor number and mRNA increased 4- to 6-fold while both fell in white adipose tissue, T3 injection reverted the changes within 24 hours, and T3 excess caused a greater than 90% reduction of beta-3 receptor mRNA in brown fat but a 5-fold increase in white fat.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/cold-research/7628361.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "ee7ba7cfa7ae3387c067f33a03ad9c212801437175f6cb656d5e86b482ed8d64", "start_char": 0, "end_char": 2080, "text_sha256": "ee7ba7cfa7ae3387c067f33a03ad9c212801437175f6cb656d5e86b482ed8d64"}
- experimental_model
- Brown and white adipose tissue of hypothyroid and T3-treated rats
- exposure
- Hypothyroidism, T3 replacement and T3 excess
- limitations
- The reciprocal regulation in the two tissues is the informative part. A post-receptor cAMP defect persisted after receptor numbers were corrected, so receptor count is not the whole story.
- nutrient_topic
- Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. · Cold water immersion
- organism
- Rat
- plain_language
- Thyroid hormone tunes how loudly each fat depot hears the nerve signal, in opposite directions.
- primary_references
- [cold-p7628361] Thyroid hormone and norepinephrine signaling in brown adipose tissue. II: Differential effects of thyroid hormone on beta 3-adrenergic receptors in brown and white adipose tissue. (1995). https://pubmed.ncbi.nlm.nih.gov/7628361/ DOI: 10.1210/endo.136.8.7628361
- tissue_or_cell_type
- Brown and white adipose tissue
Cold water immersion: cold sensing, heat production, the catecholamine axis and what repeated exposure changes (2026-09-19) · lines 429–440
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Brown and white adipose tissue of hypothyroid and T3-treated rats · source_derived_draft · unverified_draft
### cold-thyroid-beta3-regulation In brown adipose tissue of hypothyroid rats beta-3 adrenergic receptor number and mRNA increased 4- to 6-fold while both fell in white adipose tissue, T3 injection reverted the changes within 24 hours, and T3 excess caused a greater than 90% reduction of beta-3 receptor mRNA in brown fat but a 5-fold increase in white fat. Condition category: normal nutrient_topic: Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. plain_language: Thyroid hormone tunes how loudly each fat depot hears the nerve signal, in opposite directions. organism: Rat tissue_or_cell_type: Brown and white adipose tissue experimental_model: Brown and white adipose tissue of hypothyroid and T3-treated rats limitations: The reciprocal regulation in the two tissues is the informative part. A post-receptor cAMP defect persisted after receptor numbers were corrected, so receptor count is not the whole story. exposure: Hypothyroidism, T3 replacement and T3 excess evidence_span: {"source_cache": "artifacts/cold-research/7628361.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "ee7ba7cfa7ae3387c067f33a03ad9c212801437175f6cb656d5e86b482ed8d64", "start_char": 0, "end_char": 2080, "text_sha256": "ee7ba7cfa7ae3387c067f33a03ad9c212801437175f6cb656d5e86b482ed8d64"} [cold-p7628361] Thyroid hormone and norepinephrine signaling in brown adipose tissue. II: Differential effects of thyroid hormone on beta 3-adrenergic receptors in brown and white adipose tissue. (1995). https://pubmed.ncbi.nlm.nih.gov/7628361/ DOI: 10.1210/endo.136.8.7628361
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.