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A post-receptor cAMP defect persisted after receptor numbers were corrected, so receptor count is not the whole story.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake.","comparator":null,"unit":null,"notes":"","entity":{"slug":"cold-water-immersion","display_name":"Cold water immersion","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Rat","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Thyroid hormone tunes how loudly each fat depot hears the nerve signal, in opposite directions.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[cold-p7628361] Thyroid hormone and norepinephrine signaling in brown adipose tissue. 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A post-receptor cAMP defect persisted after receptor numbers were corrected, so receptor count is not the whole story.\nexposure: Hypothyroidism, T3 replacement and T3 excess\nevidence_span: {\"source_cache\": \"artifacts/cold-research/7628361.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"ee7ba7cfa7ae3387c067f33a03ad9c212801437175f6cb656d5e86b482ed8d64\", \"start_char\": 0, \"end_char\": 2080, \"text_sha256\": \"ee7ba7cfa7ae3387c067f33a03ad9c212801437175f6cb656d5e86b482ed8d64\"}\n[cold-p7628361] Thyroid hormone and norepinephrine signaling in brown adipose tissue. II: Differential effects of thyroid hormone on beta 3-adrenergic receptors in brown and white adipose tissue. 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