{"id":"54fb97d5-7693-5f9e-a267-22ef31df080c","stable_key":"a8baf7e9-80e4-5d8c-adec-9a63e84d2f21:l-cysteine-fgf21-cysteine-only-limit","predicate":"is_not_required_for_tested","statement":"Additional Fgf21 deletion in Cth-null mice did not prevent the rapid weight-loss phenotype during cysteine-free feeding.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"1b85de35-4f9a-5639-be67-7fdab455cb20","mechanism_event_label":"An increased hormone level did not make that hormone necessary for this outcome.","subject":{"id":"8b01fe3c-a32b-5076-9c61-34d4d35e8b89","slug":"mouse-fgf21","display_name":"Mouse fibroblast growth factor 21 / Fgf21","entity_type_key":"protein"},"object":{"id":"ea7d72df-c02d-5680-907a-66c588e31392","slug":"mouse-cysteine-depletion-weight-loss","display_name":"Weight loss during systemic cysteine depletion in mice","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"1b85de35-4f9a-5639-be67-7fdab455cb20","stable_key":"a8baf7e9-80e4-5d8c-adec-9a63e84d2f21:l-cysteine-fgf21-cysteine-only-limit-event","event_type":"observed_relationship","label":"An increased hormone level did not make that hormone necessary for this outcome.","description":"Additional Fgf21 deletion in Cth-null mice did not prevent the rapid weight-loss phenotype during cysteine-free feeding.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8b01fe3c-a32b-5076-9c61-34d4d35e8b89","slug":"mouse-fgf21","display_name":"Mouse fibroblast growth factor 21 / Fgf21","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ea7d72df-c02d-5680-907a-66c588e31392","slug":"mouse-cysteine-depletion-weight-loss","display_name":"Weight loss during systemic cysteine depletion in mice","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ca899f13-50ad-55e5-ab99-329ae0038c74","slug":"l-cysteine","display_name":"L-Cysteine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"09418c83-db15-582a-92a2-7d928f3ec14a","slug":"mouse-cth","display_name":"Mouse cystathionine gamma-lyase / Cth","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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