Component

Moringin / MIC-1

4-(alpha-L-rhamnosyloxy)benzyl isothiocyanate formed from glucomoringin by myrosinase.

6 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. In the same in-vitro comparison, moringin did not activate or only weakly activated TRPV1, TRPV2, TRPV3, TRPV4 and TRPM8 relative to its TRPA1 activity.

    Moringin / MIC-1 → Human TRPV1-TRPV4 and TRPM8 channel panel source_derived_draftungraded
    Experimental context and source evidence
    dose
    Purified moringin
    duration
    Acute
    evidence_access
    Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
    evidence_scope
    literature_reviewed; model-specific source-derived curation
    experimental_model
    Human TRP-channel in-vitro assays
    limitations
    This selectivity result is assay-specific and does not exclude indirect effects on sensory signaling in vivo.
    nutrient_topic
    Moringa oleifera chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings. · Moringa oleifera
    organism
    Human TRP-channel in-vitro assays
    plain_language
    In the same in-vitro comparison, moringin did not activate or only weakly activated TRPV1, TRPV2, TRPV3, TRPV4 and TRPM8 relative to its TRPA1 activity.
    primary_references
    Moringin, A Stable Isothiocyanate from Moringa oleifera, Activates the Somatosensory and Pain Receptor TRPA1 Channel In Vitro. (2020). https://pubmed.ncbi.nlm.nih.gov/32098328/ DOI: 10.3390/molecules25040976
    route
    In vitro
    tissue
    Channel selectivity panel

    Moringa oleifera: mechanism of action and interactions (2026-09-20) · lines 57–66

    Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text. · supports · Human TRP-channel in-vitro assays · source_derived_draft · unverified_draft

    ## moringa-moringin-trp-selectivity In the same in-vitro comparison, moringin did not activate or only weakly activated TRPV1, TRPV2, TRPV3, TRPV4 and TRPM8 relative to its TRPA1 activity. Model/species: Human TRP-channel in-vitro assays Tissue/system: Channel selectivity panel Exposure: Purified moringin Route: In vitro Duration: Acute Limits: This selectivity result is assay-specific and does not exclude indirect effects on sensory signaling in vivo. Primary reference: Moringin, A Stable Isothiocyanate from Moringa oleifera, Activates the Somatosensory and Pain Receptor TRPA1 Channel In Vitro. (2020). https://pubmed.ncbi.nlm.nih.gov/32098328/ DOI: 10.3390/molecules25040976 Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
    Complete structured claim and evidence

  2. Purified moringin acted as a potent agonist of human TRPA1 in vitro.

    Moringin / MIC-1 → Human TRPA1 ion channel source_derived_draftungraded
    Experimental context and source evidence
    dose
    Purified moringin concentration series
    duration
    Acute
    evidence_access
    Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
    evidence_scope
    literature_reviewed; model-specific source-derived curation
    experimental_model
    Human TRPA1-expressing in-vitro channel assay
    limitations
    Channel activation in an expression assay does not establish analgesia, pain, dose or tissue exposure in humans.
    nutrient_topic
    Moringa oleifera chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings. · Moringa oleifera
    organism
    Human TRPA1-expressing in-vitro channel assay
    plain_language
    Purified moringin acted as a potent agonist of human TRPA1 in vitro.
    primary_references
    Moringin, A Stable Isothiocyanate from Moringa oleifera, Activates the Somatosensory and Pain Receptor TRPA1 Channel In Vitro. (2020). https://pubmed.ncbi.nlm.nih.gov/32098328/ DOI: 10.3390/molecules25040976
    route
    In vitro
    tissue
    Somatosensory ion-channel activation

    Moringa oleifera: mechanism of action and interactions (2026-09-20) · lines 46–55

    Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text. · supports · Human TRPA1-expressing in-vitro channel assay · source_derived_draft · unverified_draft

    ## moringa-moringin-trpa1 Purified moringin acted as a potent agonist of human TRPA1 in vitro. Model/species: Human TRPA1-expressing in-vitro channel assay Tissue/system: Somatosensory ion-channel activation Exposure: Purified moringin concentration series Route: In vitro Duration: Acute Limits: Channel activation in an expression assay does not establish analgesia, pain, dose or tissue exposure in humans. Primary reference: Moringin, A Stable Isothiocyanate from Moringa oleifera, Activates the Somatosensory and Pain Receptor TRPA1 Channel In Vitro. (2020). https://pubmed.ncbi.nlm.nih.gov/32098328/ DOI: 10.3390/molecules25040976 Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
    Complete structured claim and evidence

What acts on it

  1. Cannabidiol plus moringin, each at 5 micromolar, produced larger changes in inflammatory, oxidative and apoptosis markers in LPS-stimulated murine macrophages than either constituent alone at that concentration.

    Cannabidiol → Moringin / MIC-1 source_derived_draftungraded
    Experimental context and source evidence
    dose
    Cannabidiol 5 micromolar plus moringin 5 micromolar
    duration
    Acute
    evidence_access
    Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
    evidence_scope
    literature_reviewed; model-specific source-derived curation
    experimental_model
    LPS-stimulated murine macrophages
    limitations
    This cell combination result does not establish clinical synergy, safety or dosing and should not be extrapolated to cannabis or whole Moringa products.
    nutrient_topic
    Moringa oleifera chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings. · Moringa oleifera
    organism
    LPS-stimulated murine macrophages
    plain_language
    Cannabidiol plus moringin, each at 5 micromolar, produced larger changes in inflammatory, oxidative and apoptosis markers in LPS-stimulated murine macrophages than either constituent alone at that concentration.
    primary_references
    Anti-inflammatory and antioxidant effects of a combination of cannabidiol and moringin in LPS-stimulated macrophages. (2016). https://pubmed.ncbi.nlm.nih.gov/27215129/ DOI: 10.1016/j.fitote.2016.05.008
    route
    In vitro
    tissue
    TNF-alpha, IL-10, iNOS, NRF2, nitrotyrosine, BCL2, BAX and cleaved-caspase-3 panel

    Moringa oleifera: mechanism of action and interactions (2026-09-20) · lines 90–99

    Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text. · supports · LPS-stimulated murine macrophages · source_derived_draft · unverified_draft

    ## moringa-cannabidiol-combination Cannabidiol plus moringin, each at 5 micromolar, produced larger changes in inflammatory, oxidative and apoptosis markers in LPS-stimulated murine macrophages than either constituent alone at that concentration. Model/species: LPS-stimulated murine macrophages Tissue/system: TNF-alpha, IL-10, iNOS, NRF2, nitrotyrosine, BCL2, BAX and cleaved-caspase-3 panel Exposure: Cannabidiol 5 micromolar plus moringin 5 micromolar Route: In vitro Duration: Acute Limits: This cell combination result does not establish clinical synergy, safety or dosing and should not be extrapolated to cannabis or whole Moringa products. Primary reference: Anti-inflammatory and antioxidant effects of a combination of cannabidiol and moringin in LPS-stimulated macrophages. (2016). https://pubmed.ncbi.nlm.nih.gov/27215129/ DOI: 10.1016/j.fitote.2016.05.008 Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
    Complete structured claim and evidence

  2. During standardized cold-water extraction of dried Moringa leaves, endogenous myrosinase converted glucomoringin to moringin; isothiocyanate yield was rapid and essentially complete after 30 minutes.

    Glucomoringin → Moringin / MIC-1 source_derived_draftungraded
    Experimental context and source evidence
    dose
    Calibrated cold-water extraction
    duration
    30 minutes
    evidence_access
    Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
    evidence_scope
    literature_reviewed; model-specific source-derived curation
    experimental_model
    Dried Moringa leaves and aqueous tea preparations
    limitations
    A standardized tea protocol does not establish the moringin dose in every household tea, cooked leaf, powder or capsule.
    nutrient_topic
    Moringa oleifera chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings. · Moringa oleifera
    organism
    Dried Moringa leaves and aqueous tea preparations
    plain_language
    During standardized cold-water extraction of dried Moringa leaves, endogenous myrosinase converted glucomoringin to moringin; isothiocyanate yield was rapid and essentially complete after 30 minutes.
    primary_references
    A Strategy to Deliver Precise Oral Doses of the Glucosinolates or Isothiocyanates from Moringa oleifera Leaves for Use in Clinical Studies. (2019). https://pubmed.ncbi.nlm.nih.gov/31323988/ DOI: 10.3390/nu11071547
    route
    Ex vivo food preparation
    tissue
    Glucosinolate/isothiocyanate preparation chemistry

    Moringa oleifera: mechanism of action and interactions (2026-09-20) · lines 13–22

    Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text. · supports · Dried Moringa leaves and aqueous tea preparations · source_derived_draft · unverified_draft

    ## moringa-cold-water-myrosinase-conversion During standardized cold-water extraction of dried Moringa leaves, endogenous myrosinase converted glucomoringin to moringin; isothiocyanate yield was rapid and essentially complete after 30 minutes. Model/species: Dried Moringa leaves and aqueous tea preparations Tissue/system: Glucosinolate/isothiocyanate preparation chemistry Exposure: Calibrated cold-water extraction Route: Ex vivo food preparation Duration: 30 minutes Limits: A standardized tea protocol does not establish the moringin dose in every household tea, cooked leaf, powder or capsule. Primary reference: A Strategy to Deliver Precise Oral Doses of the Glucosinolates or Isothiocyanates from Moringa oleifera Leaves for Use in Clinical Studies. (2019). https://pubmed.ncbi.nlm.nih.gov/31323988/ DOI: 10.3390/nu11071547 Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. A TRPV1 antagonist impaired cannabidiol efficacy in the macrophage assay but did not alter moringin activity; CB1 and CB2 antagonists affected neither route.

    Human transient receptor potential vanilloid 1 / TRPV1 → TRPV1-sensitive cannabidiol efficacy but TRPV1-insensitive moringin efficacy in macrophages source_derived_draftungraded
    Experimental context and source evidence
    dose
    Cannabidiol or moringin with TRPV1, CB1 or CB2 antagonists
    duration
    Acute
    evidence_access
    Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
    evidence_scope
    literature_reviewed; model-specific source-derived curation
    experimental_model
    LPS-stimulated murine macrophages
    limitations
    The abstract does not establish direct binding of either compound to every tested receptor, and the result is not a clinical interaction.
    nutrient_topic
    Moringa oleifera chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings. · Moringa oleifera
    organism
    LPS-stimulated murine macrophages
    plain_language
    A TRPV1 antagonist impaired cannabidiol efficacy in the macrophage assay but did not alter moringin activity; CB1 and CB2 antagonists affected neither route.
    primary_references
    Anti-inflammatory and antioxidant effects of a combination of cannabidiol and moringin in LPS-stimulated macrophages. (2016). https://pubmed.ncbi.nlm.nih.gov/27215129/ DOI: 10.1016/j.fitote.2016.05.008
    route
    In vitro perturbation
    tissue
    Receptor-antagonist separation of combination components

    Moringa oleifera: mechanism of action and interactions (2026-09-20) · lines 101–110

    Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text. · supports · LPS-stimulated murine macrophages · source_derived_draft · unverified_draft

    ## moringa-cannabidiol-trpv1-separation A TRPV1 antagonist impaired cannabidiol efficacy in the macrophage assay but did not alter moringin activity; CB1 and CB2 antagonists affected neither route. Model/species: LPS-stimulated murine macrophages Tissue/system: Receptor-antagonist separation of combination components Exposure: Cannabidiol or moringin with TRPV1, CB1 or CB2 antagonists Route: In vitro perturbation Duration: Acute Limits: The abstract does not establish direct binding of either compound to every tested receptor, and the result is not a clinical interaction. Primary reference: Anti-inflammatory and antioxidant effects of a combination of cannabidiol and moringin in LPS-stimulated macrophages. (2016). https://pubmed.ncbi.nlm.nih.gov/27215129/ DOI: 10.1016/j.fitote.2016.05.008 Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
    Complete structured claim and evidence

  2. The standardized multi-constituent ME-D leaf preparation increased NRF2-regulated NQO1 and HMOX1 expression and cellular glutathione in BEAS-2B cells, and increased NRF2-regulated genes after oral dosing in mice.

    Standardized palatable Moringa leaf preparation ME-D → NRF2-linked NQO1, HMOX1 and glutathione response to ME-D source_derived_draftungraded
    Experimental context and source evidence
    dose
    Chemically profiled ME-D hot-soup or freeze-dried preparation
    duration
    Acute cell exposure and study-specified mouse dosing
    evidence_access
    Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
    evidence_scope
    literature_reviewed; model-specific source-derived curation
    experimental_model
    Human BEAS-2B cells and orally dosed mice
    limitations
    The preparation contained moringin, glucomoringin and polyphenols, so the response cannot be assigned to one constituent or treated as a human clinical outcome.
    nutrient_topic
    Moringa oleifera chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings. · Moringa oleifera
    organism
    Human BEAS-2B cells and orally dosed mice
    plain_language
    The standardized multi-constituent ME-D leaf preparation increased NRF2-regulated NQO1 and HMOX1 expression and cellular glutathione in BEAS-2B cells, and increased NRF2-regulated genes after oral dosing in mice.
    primary_references
    Development of Moringa oleifera as functional food targeting NRF2 signaling: antioxidant and anti-inflammatory activity in experimental model systems. (2023). https://pubmed.ncbi.nlm.nih.gov/37114361/ DOI: 10.1039/d3fo00572k
    route
    In vitro and oral mouse exposure
    tissue
    NRF2-linked gene and glutathione responses

    Moringa oleifera: mechanism of action and interactions (2026-09-20) · lines 68–77

    Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text. · supports · Human BEAS-2B cells and orally dosed mice · source_derived_draft · unverified_draft

    ## moringa-standardized-preparation-nrf2 The standardized multi-constituent ME-D leaf preparation increased NRF2-regulated NQO1 and HMOX1 expression and cellular glutathione in BEAS-2B cells, and increased NRF2-regulated genes after oral dosing in mice. Model/species: Human BEAS-2B cells and orally dosed mice Tissue/system: NRF2-linked gene and glutathione responses Exposure: Chemically profiled ME-D hot-soup or freeze-dried preparation Route: In vitro and oral mouse exposure Duration: Acute cell exposure and study-specified mouse dosing Limits: The preparation contained moringin, glucomoringin and polyphenols, so the response cannot be assigned to one constituent or treated as a human clinical outcome. Primary reference: Development of Moringa oleifera as functional food targeting NRF2 signaling: antioxidant and anti-inflammatory activity in experimental model systems. (2023). https://pubmed.ncbi.nlm.nih.gov/37114361/ DOI: 10.1039/d3fo00572k Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards