{"id":"62e59fc6-e443-5d91-91b5-4a6776c03848","stable_key":"16c35a72-8162-5bb1-ae01-45331b8b42d0:moringa-moringin-trp-selectivity","predicate":"weakly_or_does_not_activate","statement":"In the same in-vitro comparison, moringin did not activate or only weakly activated TRPV1, TRPV2, TRPV3, TRPV4 and TRPM8 relative to its TRPA1 activity.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"695aa8fa-9675-5eeb-9efc-eb0a88abc0d5","mechanism_event_label":"In the same in-vitro comparison, moringin did not activate or only weakly activated TRPV1, TRPV2, TRPV3, TRPV4 and TRPM8 relative to its TRPA1 activity.","subject":{"id":"18d01b02-1f9f-5dfd-8df2-a27c1899fa9c","slug":"moringin","display_name":"Moringin / MIC-1","entity_type_key":"small_molecule"},"object":{"id":"e2267067-496f-53ba-ab7a-eac79749f27a","slug":"human-trpv1-4-trpm8-panel","display_name":"Human TRPV1-TRPV4 and TRPM8 channel panel","entity_type_key":"protein_set"},"evidence_count":1,"mechanism_event":{"id":"695aa8fa-9675-5eeb-9efc-eb0a88abc0d5","stable_key":"16c35a72-8162-5bb1-ae01-45331b8b42d0:moringa-moringin-trp-selectivity-event","event_type":"observed_relationship","label":"In the same in-vitro comparison, moringin did not activate or only weakly activated TRPV1, TRPV2, TRPV3, TRPV4 and TRPM8 relative to its TRPA1 activity.","description":"In the same in-vitro comparison, moringin did not activate or only weakly activated TRPV1, TRPV2, TRPV3, TRPV4 and TRPM8 relative to its TRPA1 activity.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"18d01b02-1f9f-5dfd-8df2-a27c1899fa9c","slug":"moringin","display_name":"Moringin / MIC-1","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e2267067-496f-53ba-ab7a-eac79749f27a","slug":"human-trpv1-4-trpm8-panel","display_name":"Human TRPV1-TRPV4 and TRPM8 channel panel","entity_type_key":"protein_set"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"44366bfb-222d-5da6-911a-e853c3d7cdb7","slug":"human-trpa1","display_name":"Human TRPA1 ion channel","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"8e0c61d8-3930-51d5-bce2-25a5edfb797c","slug":"human-trpv1","display_name":"Human transient receptor potential vanilloid 1 / TRPV1","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Purified moringin","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Acute","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human TRP-channel in-vitro assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This selectivity result is assay-specific and does not exclude indirect effects on sensory signaling in vivo.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Moringa oleifera chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings.","comparator":null,"unit":null,"notes":"","entity":{"slug":"moringa","display_name":"Moringa oleifera","entity_type_key":"botanical"}},{"dimension":"organism","value_text":"Human TRP-channel in-vitro assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"In the same in-vitro comparison, moringin did not activate or only weakly activated TRPV1, TRPV2, TRPV3, TRPV4 and TRPM8 relative to its TRPA1 activity.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Moringin, A Stable Isothiocyanate from Moringa oleifera, Activates the Somatosensory and Pain Receptor TRPA1 Channel In Vitro. (2020). https://pubmed.ncbi.nlm.nih.gov/32098328/ DOI: 10.3390/molecules25040976","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In vitro","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Channel selectivity panel","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"fea5c397-129e-53cf-b037-d3a03eecc577","evidence_kind":"source_excerpt","locator":"Lines 57-66","start_line":57,"end_line":66,"excerpt":"## moringa-moringin-trp-selectivity\nIn the same in-vitro comparison, moringin did not activate or only weakly activated TRPV1, TRPV2, TRPV3, TRPV4 and TRPM8 relative to its TRPA1 activity.\nModel/species: Human TRP-channel in-vitro assays\nTissue/system: Channel selectivity panel\nExposure: Purified moringin\nRoute: In vitro\nDuration: Acute\nLimits: This selectivity result is assay-specific and does not exclude indirect effects on sensory signaling in vivo.\nPrimary reference: Moringin, A Stable Isothiocyanate from Moringa oleifera, Activates the Somatosensory and Pain Receptor TRPA1 Channel In Vitro. (2020). https://pubmed.ncbi.nlm.nih.gov/32098328/ DOI: 10.3390/molecules25040976\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"Human TRP-channel in-vitro assays","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span with primary citation; not a publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2752e9b3-e4b9-55fe-be07-944204cca4b8","stable_key":"import-16c35a72-8162-5bb1-ae01-45331b8b42d0","title":"Moringa oleifera: mechanism of action and interactions (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text.","file_path":"","sha256":"c4146a85ed4997fa117a83862fcf605ffb74110cf9f9cac8c63d1f6b07b8a57c","revision_id":"399ef3a4-8939-5df0-9f90-71d41dd6bab8","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}