{"id":"5d67143e-fd53-5256-af8e-5f062af72286","stable_key":"16c35a72-8162-5bb1-ae01-45331b8b42d0:moringa-cold-water-myrosinase-conversion","predicate":"is_converted_by","statement":"During standardized cold-water extraction of dried Moringa leaves, endogenous myrosinase converted glucomoringin to moringin; isothiocyanate yield was rapid and essentially complete after 30 minutes.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"0814528e-ed41-56a7-92b8-c65dc6862bf1","mechanism_event_label":"During standardized cold-water extraction of dried Moringa leaves, endogenous myrosinase converted glucomoringin to moringin; isothiocyanate yield was rapid and essentially complete after 30 minutes.","subject":{"id":"6d239d9e-2d14-57b0-b6df-636aa00b9c2c","slug":"glucomoringin","display_name":"Glucomoringin","entity_type_key":"small_molecule"},"object":{"id":"18d01b02-1f9f-5dfd-8df2-a27c1899fa9c","slug":"moringin","display_name":"Moringin / MIC-1","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"0814528e-ed41-56a7-92b8-c65dc6862bf1","stable_key":"16c35a72-8162-5bb1-ae01-45331b8b42d0:moringa-cold-water-myrosinase-conversion-event","event_type":"observed_relationship","label":"During standardized cold-water extraction of dried Moringa leaves, endogenous myrosinase converted glucomoringin to moringin; isothiocyanate yield was rapid and essentially complete after 30 minutes.","description":"During standardized cold-water extraction of dried Moringa leaves, endogenous myrosinase converted glucomoringin to moringin; isothiocyanate yield was rapid and essentially complete after 30 minutes.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6d239d9e-2d14-57b0-b6df-636aa00b9c2c","slug":"glucomoringin","display_name":"Glucomoringin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"18d01b02-1f9f-5dfd-8df2-a27c1899fa9c","slug":"moringin","display_name":"Moringin / MIC-1","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"30f490e4-34ad-5282-8f31-9dc611146545","slug":"moringa-myrosinase","display_name":"Moringa oleifera myrosinase","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"dd76de93-3426-5121-a1c7-5d492193169e","slug":"moringa-cold-water-tea","display_name":"Standardized cold-water Moringa leaf tea","entity_type_key":"botanical"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Calibrated cold-water extraction","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"30 minutes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Dried Moringa leaves and aqueous tea preparations","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A standardized tea protocol does not establish the moringin dose in every household tea, cooked leaf, powder or capsule.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Moringa oleifera chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings.","comparator":null,"unit":null,"notes":"","entity":{"slug":"moringa","display_name":"Moringa oleifera","entity_type_key":"botanical"}},{"dimension":"organism","value_text":"Dried Moringa leaves and aqueous tea preparations","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"During standardized cold-water extraction of dried Moringa leaves, endogenous myrosinase converted glucomoringin to moringin; isothiocyanate yield was rapid and essentially complete after 30 minutes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"A Strategy to Deliver Precise Oral Doses of the Glucosinolates or Isothiocyanates from Moringa oleifera Leaves for Use in Clinical Studies. (2019). https://pubmed.ncbi.nlm.nih.gov/31323988/ DOI: 10.3390/nu11071547","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Ex vivo food preparation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Glucosinolate/isothiocyanate preparation chemistry","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"5182bae4-32e3-58d4-9cef-857fd6717769","evidence_kind":"source_excerpt","locator":"Lines 13-22","start_line":13,"end_line":22,"excerpt":"## moringa-cold-water-myrosinase-conversion\nDuring standardized cold-water extraction of dried Moringa leaves, endogenous myrosinase converted glucomoringin to moringin; isothiocyanate yield was rapid and essentially complete after 30 minutes.\nModel/species: Dried Moringa leaves and aqueous tea preparations\nTissue/system: Glucosinolate/isothiocyanate preparation chemistry\nExposure: Calibrated cold-water extraction\nRoute: Ex vivo food preparation\nDuration: 30 minutes\nLimits: A standardized tea protocol does not establish the moringin dose in every household tea, cooked leaf, powder or capsule.\nPrimary reference: A Strategy to Deliver Precise Oral Doses of the Glucosinolates or Isothiocyanates from Moringa oleifera Leaves for Use in Clinical Studies. (2019). https://pubmed.ncbi.nlm.nih.gov/31323988/ DOI: 10.3390/nu11071547\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"Dried Moringa leaves and aqueous tea preparations","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span with primary citation; not a publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2752e9b3-e4b9-55fe-be07-944204cca4b8","stable_key":"import-16c35a72-8162-5bb1-ae01-45331b8b42d0","title":"Moringa oleifera: mechanism of action and interactions (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. 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