Component

Sodium-metasilicate-derived soluble silicon culture preparation

Context-specific entity; species, compartment and exposure are stated on each claim.

9 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

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What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Silicon-treated HUVECs increased catalase mRNA under the reported normal and peroxide conditions.

    Sodium-metasilicate-derived soluble silicon culture preparation → Human catalase source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text
    experimental_model
    Human HUVECs, 0.5 mM silicon preparation.
    limitations
    Expression is not measured catalytic flux or proof that silicon replaces established metal cofactors.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    An individual antioxidant or vascular enzyme was measured.
    primary_references
    Ionic silicon improves endothelial cells' survival under toxic oxidative stress by overexpressing angiogenic markers and antioxidant enzymes. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30062712/ · DOI 10.1002/term.2744

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 304–310

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human HUVECs, 0.5 mM silicon preparation. · source_derived_draft · unverified_draft

    ## silica-endothelial-human-catalase An individual antioxidant or vascular enzyme was measured. Silicon-treated HUVECs increased catalase mRNA under the reported normal and peroxide conditions. Model: Human HUVECs, 0.5 mM silicon preparation. Limitations: Expression is not measured catalytic flux or proof that silicon replaces established metal cofactors. Evidence access: Primary full text Ionic silicon improves endothelial cells' survival under toxic oxidative stress by overexpressing angiogenic markers and antioxidant enzymes. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30062712/ · DOI 10.1002/term.2744
    Complete structured claim and evidence

  2. The 0.5 mM silicon preparation increased HIF1A expression in HUVECs with or without the tested peroxide challenge.

    Sodium-metasilicate-derived soluble silicon culture preparation → HIF-1 alpha source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text
    experimental_model
    Human endothelial cultures; sodium-metasilicate-derived preparation.
    limitations
    Expression association does not establish direct activation or clinical angiogenesis.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    A distinct vascular regulator changed after exposure.
    primary_references
    Ionic silicon improves endothelial cells' survival under toxic oxidative stress by overexpressing angiogenic markers and antioxidant enzymes. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30062712/ · DOI 10.1002/term.2744

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 528–534

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human endothelial cultures; sodium-metasilicate-derived preparation. · source_derived_draft · unverified_draft

    ## silica-endothelial-marker-hif1a A distinct vascular regulator changed after exposure. The 0.5 mM silicon preparation increased HIF1A expression in HUVECs with or without the tested peroxide challenge. Model: Human endothelial cultures; sodium-metasilicate-derived preparation. Limitations: Expression association does not establish direct activation or clinical angiogenesis. Evidence access: Primary full text Ionic silicon improves endothelial cells' survival under toxic oxidative stress by overexpressing angiogenic markers and antioxidant enzymes. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30062712/ · DOI 10.1002/term.2744
    Complete structured claim and evidence

  3. The 0.5 mM silicon preparation increased VEGFR2 / KDR expression in HUVECs with or without the tested peroxide challenge.

    Sodium-metasilicate-derived soluble silicon culture preparation → Human VEGFR2 / KDR source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text
    experimental_model
    Human endothelial cultures; sodium-metasilicate-derived preparation.
    limitations
    Expression association does not establish direct activation or clinical angiogenesis.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    A distinct vascular regulator changed after exposure.
    primary_references
    Ionic silicon improves endothelial cells' survival under toxic oxidative stress by overexpressing angiogenic markers and antioxidant enzymes. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30062712/ · DOI 10.1002/term.2744

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 544–550

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human endothelial cultures; sodium-metasilicate-derived preparation. · source_derived_draft · unverified_draft

    ## silica-endothelial-marker-human-kdr A distinct vascular regulator changed after exposure. The 0.5 mM silicon preparation increased VEGFR2 / KDR expression in HUVECs with or without the tested peroxide challenge. Model: Human endothelial cultures; sodium-metasilicate-derived preparation. Limitations: Expression association does not establish direct activation or clinical angiogenesis. Evidence access: Primary full text Ionic silicon improves endothelial cells' survival under toxic oxidative stress by overexpressing angiogenic markers and antioxidant enzymes. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30062712/ · DOI 10.1002/term.2744
    Complete structured claim and evidence

  4. The 0.5 mM silicon preparation increased VEGFA expression in HUVECs with or without the tested peroxide challenge.

    Sodium-metasilicate-derived soluble silicon culture preparation → Human VEGFA source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text
    experimental_model
    Human endothelial cultures; sodium-metasilicate-derived preparation.
    limitations
    Expression association does not establish direct activation or clinical angiogenesis.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    A distinct vascular regulator changed after exposure.
    primary_references
    Ionic silicon improves endothelial cells' survival under toxic oxidative stress by overexpressing angiogenic markers and antioxidant enzymes. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30062712/ · DOI 10.1002/term.2744

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 536–542

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human endothelial cultures; sodium-metasilicate-derived preparation. · source_derived_draft · unverified_draft

    ## silica-endothelial-marker-human-vegfa A distinct vascular regulator changed after exposure. The 0.5 mM silicon preparation increased VEGFA expression in HUVECs with or without the tested peroxide challenge. Model: Human endothelial cultures; sodium-metasilicate-derived preparation. Limitations: Expression association does not establish direct activation or clinical angiogenesis. Evidence access: Primary full text Ionic silicon improves endothelial cells' survival under toxic oxidative stress by overexpressing angiogenic markers and antioxidant enzymes. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30062712/ · DOI 10.1002/term.2744
    Complete structured claim and evidence

  5. Silicon-treated HUVECs increased NOS3 mRNA under the reported normal and peroxide conditions.

    Sodium-metasilicate-derived soluble silicon culture preparation → Human endothelial nitric oxide synthase / eNOS / NOS3 source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text
    experimental_model
    Human HUVECs, 0.5 mM silicon preparation.
    limitations
    Expression is not measured catalytic flux or proof that silicon replaces established metal cofactors.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    An individual antioxidant or vascular enzyme was measured.
    primary_references
    Ionic silicon improves endothelial cells' survival under toxic oxidative stress by overexpressing angiogenic markers and antioxidant enzymes. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30062712/ · DOI 10.1002/term.2744

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 312–318

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human HUVECs, 0.5 mM silicon preparation. · source_derived_draft · unverified_draft

    ## silica-endothelial-nos3 An individual antioxidant or vascular enzyme was measured. Silicon-treated HUVECs increased NOS3 mRNA under the reported normal and peroxide conditions. Model: Human HUVECs, 0.5 mM silicon preparation. Limitations: Expression is not measured catalytic flux or proof that silicon replaces established metal cofactors. Evidence access: Primary full text Ionic silicon improves endothelial cells' survival under toxic oxidative stress by overexpressing angiogenic markers and antioxidant enzymes. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30062712/ · DOI 10.1002/term.2744
    Complete structured claim and evidence

  6. Silicon-treated HUVECs increased SOD1 mRNA under the reported normal and peroxide conditions.

    Sodium-metasilicate-derived soluble silicon culture preparation → Human copper-zinc superoxide dismutase / SOD1 source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text
    experimental_model
    Human HUVECs, 0.5 mM silicon preparation.
    limitations
    Expression is not measured catalytic flux or proof that silicon replaces established metal cofactors.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    An individual antioxidant or vascular enzyme was measured.
    primary_references
    Ionic silicon improves endothelial cells' survival under toxic oxidative stress by overexpressing angiogenic markers and antioxidant enzymes. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30062712/ · DOI 10.1002/term.2744

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 296–302

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human HUVECs, 0.5 mM silicon preparation. · source_derived_draft · unverified_draft

    ## silica-endothelial-sod1 An individual antioxidant or vascular enzyme was measured. Silicon-treated HUVECs increased SOD1 mRNA under the reported normal and peroxide conditions. Model: Human HUVECs, 0.5 mM silicon preparation. Limitations: Expression is not measured catalytic flux or proof that silicon replaces established metal cofactors. Evidence access: Primary full text Ionic silicon improves endothelial cells' survival under toxic oxidative stress by overexpressing angiogenic markers and antioxidant enzymes. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30062712/ · DOI 10.1002/term.2744
    Complete structured claim and evidence

  7. A 0.5 mM silicon preparation improved HUVEC viability during hydrogen-peroxide exposure.

    Sodium-metasilicate-derived soluble silicon culture preparation → HUVEC survival during peroxide challenge source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text
    experimental_model
    Sodium-metasilicate-derived medium; 0.6 mM H2O2 challenge.
    limitations
    Authors label exposure Si4+; this is not a measured pool of free aqueous Si4+. Supraphysiological culture exposure.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    Dissolved preparation altered the response to oxidative stress.
    primary_references
    Ionic silicon improves endothelial cells' survival under toxic oxidative stress by overexpressing angiogenic markers and antioxidant enzymes. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30062712/ · DOI 10.1002/term.2744

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 288–294

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Sodium-metasilicate-derived medium; 0.6 mM H2O2 challenge. · source_derived_draft · unverified_draft

    ## silica-endothelial-survival Dissolved preparation altered the response to oxidative stress. A 0.5 mM silicon preparation improved HUVEC viability during hydrogen-peroxide exposure. Model: Sodium-metasilicate-derived medium; 0.6 mM H2O2 challenge. Limitations: Authors label exposure Si4+; this is not a measured pool of free aqueous Si4+. Supraphysiological culture exposure. Evidence access: Primary full text Ionic silicon improves endothelial cells' survival under toxic oxidative stress by overexpressing angiogenic markers and antioxidant enzymes. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30062712/ · DOI 10.1002/term.2744
    Complete structured claim and evidence

  8. A 0.1 mM silicon preparation increased C2C12 viability, migration and myotube formation.

    Sodium-metasilicate-derived soluble silicon culture preparation → Myotube formation by mouse C2C12 cells source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text
    experimental_model
    Mouse C2C12 cultures; sodium-metasilicate-derived medium.
    limitations
    Not proof of human muscle regeneration after supplementation.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    The soluble-preparation findings extend beyond bone cells.
    primary_references
    Ionic Silicon Protects Oxidative Damage and Promotes Skeletal Muscle Cell Regeneration. · 2021 · https://pubmed.ncbi.nlm.nih.gov/33419056/ · DOI 10.3390/ijms22020497

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 320–326

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Mouse C2C12 cultures; sodium-metasilicate-derived medium. · source_derived_draft · unverified_draft

    ## silica-muscle-myotubes The soluble-preparation findings extend beyond bone cells. A 0.1 mM silicon preparation increased C2C12 viability, migration and myotube formation. Model: Mouse C2C12 cultures; sodium-metasilicate-derived medium. Limitations: Not proof of human muscle regeneration after supplementation. Evidence access: Primary full text Ionic Silicon Protects Oxidative Damage and Promotes Skeletal Muscle Cell Regeneration. · 2021 · https://pubmed.ncbi.nlm.nih.gov/33419056/ · DOI 10.3390/ijms22020497
    Complete structured claim and evidence

  9. Silicon preparations at 0.1–2 mM attenuated peroxide-associated loss of viability and differentiation.

    Sodium-metasilicate-derived soluble silicon culture preparation → Peroxide injury in mouse C2C12 cells source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text
    experimental_model
    Mouse muscle-cell culture, 24-hour challenge experiments.
    limitations
    Does not identify a direct antioxidant reaction or an in-vivo effective dose.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    Oxidative challenge changed the context in which protection was observed.
    primary_references
    Ionic Silicon Protects Oxidative Damage and Promotes Skeletal Muscle Cell Regeneration. · 2021 · https://pubmed.ncbi.nlm.nih.gov/33419056/ · DOI 10.3390/ijms22020497

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 328–334

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Mouse muscle-cell culture, 24-hour challenge experiments. · source_derived_draft · unverified_draft

    ## silica-muscle-peroxide Oxidative challenge changed the context in which protection was observed. Silicon preparations at 0.1–2 mM attenuated peroxide-associated loss of viability and differentiation. Model: Mouse muscle-cell culture, 24-hour challenge experiments. Limitations: Does not identify a direct antioxidant reaction or an in-vivo effective dose. Evidence access: Primary full text Ionic Silicon Protects Oxidative Damage and Promotes Skeletal Muscle Cell Regeneration. · 2021 · https://pubmed.ncbi.nlm.nih.gov/33419056/ · DOI 10.3390/ijms22020497
    Complete structured claim and evidence

In the sources

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