{"id":"253439db-35a6-5eb4-9b8c-157fb67f040b","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-endothelial-marker-human-vegfa","predicate":"increases_transcript","statement":"The 0.5 mM silicon preparation increased VEGFA expression in HUVECs with or without the tested peroxide challenge.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a60ef510-afbc-5df5-8608-247d286cff39","mechanism_event_label":"A distinct vascular regulator changed after exposure.","subject":{"id":"36f2ccf3-5023-5074-aab3-d65d3650b9f6","slug":"metasilicate-derived-culture-solution","display_name":"Sodium-metasilicate-derived soluble silicon culture preparation","entity_type_key":"chemical_species"},"object":{"id":"f4e8cf70-ed41-55d8-8299-62e01c83ab2d","slug":"human-vegfa","display_name":"Human VEGFA","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"a60ef510-afbc-5df5-8608-247d286cff39","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-endothelial-marker-human-vegfa-event","event_type":"observed_relationship","label":"A distinct vascular regulator changed after exposure.","description":"The 0.5 mM silicon preparation increased VEGFA expression in HUVECs with or without the tested peroxide challenge.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"36f2ccf3-5023-5074-aab3-d65d3650b9f6","slug":"metasilicate-derived-culture-solution","display_name":"Sodium-metasilicate-derived soluble silicon culture preparation","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f4e8cf70-ed41-55d8-8299-62e01c83ab2d","slug":"human-vegfa","display_name":"Human VEGFA","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"11b1cdb5-1b10-586b-9917-b4da18ac072f","slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"da9d64bc-69d4-5d97-90a4-8f0ed03e0ac8","slug":"hydrogen-peroxide","display_name":"Hydrogen peroxide","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human endothelial cultures; sodium-metasilicate-derived preparation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Expression association does not establish direct activation or clinical angiogenesis.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"A distinct vascular regulator changed after exposure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Ionic silicon improves endothelial cells' survival under toxic oxidative stress by overexpressing angiogenic markers and antioxidant enzymes. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30062712/ · DOI 10.1002/term.2744","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"9ca0acbe-f848-5d1a-8f43-dd6fc16808fd","evidence_kind":"source_excerpt","locator":"Lines 536-542","start_line":536,"end_line":542,"excerpt":"## silica-endothelial-marker-human-vegfa\nA distinct vascular regulator changed after exposure.\nThe 0.5 mM silicon preparation increased VEGFA expression in HUVECs with or without the tested peroxide challenge.\nModel: Human endothelial cultures; sodium-metasilicate-derived preparation.\nLimitations: Expression association does not establish direct activation or clinical angiogenesis.\nEvidence access: Primary full text\nIonic silicon improves endothelial cells' survival under toxic oxidative stress by overexpressing angiogenic markers and antioxidant enzymes. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30062712/ · DOI 10.1002/term.2744","model_system":"Human endothelial cultures; sodium-metasilicate-derived preparation.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc4b461e-dd46-57ab-8213-8aeb7ff9e8d0","stable_key":"import-3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd","title":"Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"e05d81962a1ca6cbfc68fce4fd3dbcdea67c8e61332c19f4fec5d0c3ab8bf1b9","revision_id":"6433ed49-a331-571b-a611-21e56c3ce4bc","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}