{"id":"e91fdf77-f712-52d2-aeae-2ef928354310","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-endothelial-survival","predicate":"improves","statement":"A 0.5 mM silicon preparation improved HUVEC viability during hydrogen-peroxide exposure.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"c9107984-9108-5bca-9748-03deb0c7d37b","mechanism_event_label":"Dissolved preparation altered the response to oxidative stress.","subject":{"id":"36f2ccf3-5023-5074-aab3-d65d3650b9f6","slug":"metasilicate-derived-culture-solution","display_name":"Sodium-metasilicate-derived soluble silicon culture preparation","entity_type_key":"chemical_species"},"object":{"id":"3f675100-7840-5d12-802f-f0b4793e1581","slug":"human-silicate-peroxide-survival","display_name":"HUVEC survival during peroxide challenge","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"c9107984-9108-5bca-9748-03deb0c7d37b","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-endothelial-survival-event","event_type":"observed_relationship","label":"Dissolved preparation altered the response to oxidative stress.","description":"A 0.5 mM silicon preparation improved HUVEC viability during hydrogen-peroxide exposure.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"36f2ccf3-5023-5074-aab3-d65d3650b9f6","slug":"metasilicate-derived-culture-solution","display_name":"Sodium-metasilicate-derived soluble silicon culture preparation","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3f675100-7840-5d12-802f-f0b4793e1581","slug":"human-silicate-peroxide-survival","display_name":"HUVEC survival during peroxide challenge","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"11b1cdb5-1b10-586b-9917-b4da18ac072f","slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"da9d64bc-69d4-5d97-90a4-8f0ed03e0ac8","slug":"hydrogen-peroxide","display_name":"Hydrogen peroxide","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Sodium-metasilicate-derived medium; 0.6 mM H2O2 challenge.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Authors label exposure Si4+; this is not a measured pool of free aqueous Si4+. 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