Low-methylesterified lemon pectin, DM7 preparation

evidence_span

{"source_cache": "artifacts/pectin-research/29545800.fulltext.txt", "locator": "Primary full-text span; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4b9e856ec2420c457b98f455ec243b742525b63d9382b69ef087456e0136cb42", "start_char": 38875, "end_char": 39612, "text_sha256": "8b75517328dfdbdd5a4290c5523e8136762b0456a8fd69af5e0e172edb168bda"}

experimental_model

Receptor binding, reporter cells, human dendritic cells and mouse ileitis model

exposure

Lemon pectin DM7 versus DM75; cell exposures 1-100 micrograms/mL; mice 3 mg/day before doxorubicin

limitations

Model-specific. Binding and cytokine experiments do not establish prevention of human inflammatory disease. Lack of increased measured SCFAs does not exclude every microbial contribution.

nutrient_topic

Pectin research collection; topical membership is not evidence of a direct dietary effect. · Pectin, structurally heterogeneous plant polysaccharides

organism

Homo sapiens

plain_language

The cell result includes IL-10; it should not be simplified to selective suppression of only harmful signals.

primary_references

[pectin-p29545800] Dietary Fiber Pectin Directly Blocks Toll-Like Receptor 2-1 and Prevents Doxorubicin-Induced Ileitis. (2018). https://pubmed.ncbi.nlm.nih.gov/29545800/ DOI: 10.3389/fimmu.2018.00383

tissue_or_cell_type

Dendritic cells

Pectin: metabolism, signaling and nutrient connections (2026-09-17) · lines 399–410

AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Receptor binding, reporter cells, human dendritic cells and mouse ileitis model · source_derived_draft · unverified_draft

### pectin-dc-il10 DM7 also reduced stimulus-dependent IL-10 release in human dendritic cells. Condition category: normal nutrient_topic: Pectin research collection; topical membership is not evidence of a direct dietary effect. plain_language: The cell result includes IL-10; it should not be simplified to selective suppression of only harmful signals. organism: Homo sapiens tissue_or_cell_type: Dendritic cells experimental_model: Receptor binding, reporter cells, human dendritic cells and mouse ileitis model limitations: Model-specific. Binding and cytokine experiments do not establish prevention of human inflammatory disease. Lack of increased measured SCFAs does not exclude every microbial contribution. exposure: Lemon pectin DM7 versus DM75; cell exposures 1-100 micrograms/mL; mice 3 mg/day before doxorubicin evidence_span: {"source_cache": "artifacts/pectin-research/29545800.fulltext.txt", "locator": "Primary full-text span; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4b9e856ec2420c457b98f455ec243b742525b63d9382b69ef087456e0136cb42", "start_char": 38875, "end_char": 39612, "text_sha256": "8b75517328dfdbdd5a4290c5523e8136762b0456a8fd69af5e0e172edb168bda"} [pectin-p29545800] Dietary Fiber Pectin Directly Blocks Toll-Like Receptor 2-1 and Prevents Doxorubicin-Induced Ileitis. (2018). https://pubmed.ncbi.nlm.nih.gov/29545800/ DOI: 10.3389/fimmu.2018.00383

evidence_span

{"source_cache": "artifacts/pectin-research/29545800.fulltext.txt", "locator": "Primary full-text span; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4b9e856ec2420c457b98f455ec243b742525b63d9382b69ef087456e0136cb42", "start_char": 38875, "end_char": 39612, "text_sha256": "8b75517328dfdbdd5a4290c5523e8136762b0456a8fd69af5e0e172edb168bda"}

experimental_model

Receptor binding, reporter cells, human dendritic cells and mouse ileitis model

exposure

Lemon pectin DM7 versus DM75; cell exposures 1-100 micrograms/mL; mice 3 mg/day before doxorubicin

limitations

Model-specific. Binding and cytokine experiments do not establish prevention of human inflammatory disease. Lack of increased measured SCFAs does not exclude every microbial contribution.

nutrient_topic

Pectin research collection; topical membership is not evidence of a direct dietary effect. · Pectin, structurally heterogeneous plant polysaccharides

organism

Homo sapiens

plain_language

Preparation structure affected how much the cells released an inflammatory messenger.

primary_references

[pectin-p29545800] Dietary Fiber Pectin Directly Blocks Toll-Like Receptor 2-1 and Prevents Doxorubicin-Induced Ileitis. (2018). https://pubmed.ncbi.nlm.nih.gov/29545800/ DOI: 10.3389/fimmu.2018.00383

tissue_or_cell_type

Dendritic cells

Pectin: metabolism, signaling and nutrient connections (2026-09-17) · lines 386–397

AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Receptor binding, reporter cells, human dendritic cells and mouse ileitis model · source_derived_draft · unverified_draft

### pectin-dc-il6 DM7 reduced stimulus-dependent IL-6 release from human dendritic cells; at lower tested concentrations DM75 did not reproduce this effect. Condition category: normal nutrient_topic: Pectin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Preparation structure affected how much the cells released an inflammatory messenger. organism: Homo sapiens tissue_or_cell_type: Dendritic cells experimental_model: Receptor binding, reporter cells, human dendritic cells and mouse ileitis model limitations: Model-specific. Binding and cytokine experiments do not establish prevention of human inflammatory disease. Lack of increased measured SCFAs does not exclude every microbial contribution. exposure: Lemon pectin DM7 versus DM75; cell exposures 1-100 micrograms/mL; mice 3 mg/day before doxorubicin evidence_span: {"source_cache": "artifacts/pectin-research/29545800.fulltext.txt", "locator": "Primary full-text span; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4b9e856ec2420c457b98f455ec243b742525b63d9382b69ef087456e0136cb42", "start_char": 38875, "end_char": 39612, "text_sha256": "8b75517328dfdbdd5a4290c5523e8136762b0456a8fd69af5e0e172edb168bda"} [pectin-p29545800] Dietary Fiber Pectin Directly Blocks Toll-Like Receptor 2-1 and Prevents Doxorubicin-Induced Ileitis. (2018). https://pubmed.ncbi.nlm.nih.gov/29545800/ DOI: 10.3389/fimmu.2018.00383

evidence_span

{"source_cache": "artifacts/pectin-research/29545800.fulltext.txt", "locator": "Primary full-text span; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4b9e856ec2420c457b98f455ec243b742525b63d9382b69ef087456e0136cb42", "start_char": 40658, "end_char": 42820, "text_sha256": "8fbd4579844713a0928cb551165880b3ad5d4b1b345b812e096ab830d0a1a0e3"}

experimental_model

Receptor binding, reporter cells, human dendritic cells and mouse ileitis model

exposure

Lemon pectin DM7 versus DM75; cell exposures 1-100 micrograms/mL; mice 3 mg/day before doxorubicin

limitations

Model-specific. Binding and cytokine experiments do not establish prevention of human inflammatory disease. Lack of increased measured SCFAs does not exclude every microbial contribution.

nutrient_topic

Pectin research collection; topical membership is not evidence of a direct dietary effect. · Pectin, structurally heterogeneous plant polysaccharides

organism

Mus musculus

plain_language

Less intestinal cell death was measured in these mice.

primary_references

[pectin-p29545800] Dietary Fiber Pectin Directly Blocks Toll-Like Receptor 2-1 and Prevents Doxorubicin-Induced Ileitis. (2018). https://pubmed.ncbi.nlm.nih.gov/29545800/ DOI: 10.3389/fimmu.2018.00383

tissue_or_cell_type

Ileum

Pectin: metabolism, signaling and nutrient connections (2026-09-17) · lines 438–449

AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Receptor binding, reporter cells, human dendritic cells and mouse ileitis model · source_derived_draft · unverified_draft

### pectin-mouse-apoptosis DM7 reduced the number of apoptotic ileal crypt cells after doxorubicin. Condition category: normal nutrient_topic: Pectin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Less intestinal cell death was measured in these mice. organism: Mus musculus tissue_or_cell_type: Ileum experimental_model: Receptor binding, reporter cells, human dendritic cells and mouse ileitis model limitations: Model-specific. Binding and cytokine experiments do not establish prevention of human inflammatory disease. Lack of increased measured SCFAs does not exclude every microbial contribution. exposure: Lemon pectin DM7 versus DM75; cell exposures 1-100 micrograms/mL; mice 3 mg/day before doxorubicin evidence_span: {"source_cache": "artifacts/pectin-research/29545800.fulltext.txt", "locator": "Primary full-text span; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4b9e856ec2420c457b98f455ec243b742525b63d9382b69ef087456e0136cb42", "start_char": 40658, "end_char": 42820, "text_sha256": "8fbd4579844713a0928cb551165880b3ad5d4b1b345b812e096ab830d0a1a0e3"} [pectin-p29545800] Dietary Fiber Pectin Directly Blocks Toll-Like Receptor 2-1 and Prevents Doxorubicin-Induced Ileitis. (2018). https://pubmed.ncbi.nlm.nih.gov/29545800/ DOI: 10.3389/fimmu.2018.00383

evidence_span

{"source_cache": "artifacts/pectin-research/29545800.fulltext.txt", "locator": "Primary full-text span; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4b9e856ec2420c457b98f455ec243b742525b63d9382b69ef087456e0136cb42", "start_char": 40658, "end_char": 42820, "text_sha256": "8fbd4579844713a0928cb551165880b3ad5d4b1b345b812e096ab830d0a1a0e3"}

experimental_model

Receptor binding, reporter cells, human dendritic cells and mouse ileitis model

exposure

Lemon pectin DM7 versus DM75; cell exposures 1-100 micrograms/mL; mice 3 mg/day before doxorubicin

limitations

Model-specific. Binding and cytokine experiments do not establish prevention of human inflammatory disease. Lack of increased measured SCFAs does not exclude every microbial contribution.

nutrient_topic

Pectin research collection; topical membership is not evidence of a direct dietary effect. · Pectin, structurally heterogeneous plant polysaccharides

organism

Mus musculus

plain_language

The animal experiment found less intestinal inflammation.

primary_references

[pectin-p29545800] Dietary Fiber Pectin Directly Blocks Toll-Like Receptor 2-1 and Prevents Doxorubicin-Induced Ileitis. (2018). https://pubmed.ncbi.nlm.nih.gov/29545800/ DOI: 10.3389/fimmu.2018.00383

tissue_or_cell_type

Ileum

Pectin: metabolism, signaling and nutrient connections (2026-09-17) · lines 425–436

AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Receptor binding, reporter cells, human dendritic cells and mouse ileitis model · source_derived_draft · unverified_draft

### pectin-mouse-ileitis DM7 reduced inflammatory features in the doxorubicin mouse ileitis model. Condition category: normal nutrient_topic: Pectin research collection; topical membership is not evidence of a direct dietary effect. plain_language: The animal experiment found less intestinal inflammation. organism: Mus musculus tissue_or_cell_type: Ileum experimental_model: Receptor binding, reporter cells, human dendritic cells and mouse ileitis model limitations: Model-specific. Binding and cytokine experiments do not establish prevention of human inflammatory disease. Lack of increased measured SCFAs does not exclude every microbial contribution. exposure: Lemon pectin DM7 versus DM75; cell exposures 1-100 micrograms/mL; mice 3 mg/day before doxorubicin evidence_span: {"source_cache": "artifacts/pectin-research/29545800.fulltext.txt", "locator": "Primary full-text span; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4b9e856ec2420c457b98f455ec243b742525b63d9382b69ef087456e0136cb42", "start_char": 40658, "end_char": 42820, "text_sha256": "8fbd4579844713a0928cb551165880b3ad5d4b1b345b812e096ab830d0a1a0e3"} [pectin-p29545800] Dietary Fiber Pectin Directly Blocks Toll-Like Receptor 2-1 and Prevents Doxorubicin-Induced Ileitis. (2018). https://pubmed.ncbi.nlm.nih.gov/29545800/ DOI: 10.3389/fimmu.2018.00383

evidence_span

{"source_cache": "artifacts/pectin-research/29545800.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c194f301d46822febd69d3bc9768bd31de73e5dd2ca87f0d3b0e64cd4726dc65", "start_char": 0, "end_char": 1540, "text_sha256": "c194f301d46822febd69d3bc9768bd31de73e5dd2ca87f0d3b0e64cd4726dc65"}

experimental_model

Receptor binding, reporter cells, human dendritic cells and mouse ileitis model

exposure

Lemon pectin DM7 versus DM75; cell exposures 1-100 micrograms/mL; mice 3 mg/day before doxorubicin

limitations

Model-specific. Binding and cytokine experiments do not establish prevention of human inflammatory disease. Lack of increased measured SCFAs does not exclude every microbial contribution.

nutrient_topic

Pectin research collection; topical membership is not evidence of a direct dietary effect. · Pectin, structurally heterogeneous plant polysaccharides

organism

Human receptor/cell assays; Mus musculus separately scoped

plain_language

Exposed acidic groups can interact directly with an immune receptor.

primary_references

[pectin-p29545800] Dietary Fiber Pectin Directly Blocks Toll-Like Receptor 2-1 and Prevents Doxorubicin-Induced Ileitis. (2018). https://pubmed.ncbi.nlm.nih.gov/29545800/ DOI: 10.3389/fimmu.2018.00383

tissue_or_cell_type

Innate immune receptors and intestine

Pectin: metabolism, signaling and nutrient connections (2026-09-17) · lines 347–358

AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Receptor binding, reporter cells, human dendritic cells and mouse ileitis model · source_derived_draft · unverified_draft

### pectin-tlr2-binding Low-DM pectin bound TLR2 with results consistent with electrostatic interaction of free galacturonate groups and positively charged receptor regions. Condition category: normal nutrient_topic: Pectin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Exposed acidic groups can interact directly with an immune receptor. organism: Human receptor/cell assays; Mus musculus separately scoped tissue_or_cell_type: Innate immune receptors and intestine experimental_model: Receptor binding, reporter cells, human dendritic cells and mouse ileitis model limitations: Model-specific. Binding and cytokine experiments do not establish prevention of human inflammatory disease. Lack of increased measured SCFAs does not exclude every microbial contribution. exposure: Lemon pectin DM7 versus DM75; cell exposures 1-100 micrograms/mL; mice 3 mg/day before doxorubicin evidence_span: {"source_cache": "artifacts/pectin-research/29545800.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c194f301d46822febd69d3bc9768bd31de73e5dd2ca87f0d3b0e64cd4726dc65", "start_char": 0, "end_char": 1540, "text_sha256": "c194f301d46822febd69d3bc9768bd31de73e5dd2ca87f0d3b0e64cd4726dc65"} [pectin-p29545800] Dietary Fiber Pectin Directly Blocks Toll-Like Receptor 2-1 and Prevents Doxorubicin-Induced Ileitis. (2018). https://pubmed.ncbi.nlm.nih.gov/29545800/ DOI: 10.3389/fimmu.2018.00383

evidence_span

{"source_cache": "artifacts/pectin-research/29545800.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c194f301d46822febd69d3bc9768bd31de73e5dd2ca87f0d3b0e64cd4726dc65", "start_char": 0, "end_char": 1540, "text_sha256": "c194f301d46822febd69d3bc9768bd31de73e5dd2ca87f0d3b0e64cd4726dc65"}

experimental_model

Receptor binding, reporter cells, human dendritic cells and mouse ileitis model

exposure

Lemon pectin DM7 versus DM75; cell exposures 1-100 micrograms/mL; mice 3 mg/day before doxorubicin

limitations

Model-specific. Binding and cytokine experiments do not establish prevention of human inflammatory disease. Lack of increased measured SCFAs does not exclude every microbial contribution.

nutrient_topic

Pectin research collection; topical membership is not evidence of a direct dietary effect. · Pectin, structurally heterogeneous plant polysaccharides

organism

Human receptor/cell assays; Mus musculus separately scoped

plain_language

This pectin preparation reduced one receptor-pair signal.

primary_references

[pectin-p29545800] Dietary Fiber Pectin Directly Blocks Toll-Like Receptor 2-1 and Prevents Doxorubicin-Induced Ileitis. (2018). https://pubmed.ncbi.nlm.nih.gov/29545800/ DOI: 10.3389/fimmu.2018.00383

tissue_or_cell_type

Innate immune receptors and intestine

Pectin: metabolism, signaling and nutrient connections (2026-09-17) · lines 360–371

AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Receptor binding, reporter cells, human dendritic cells and mouse ileitis model · source_derived_draft · unverified_draft

### pectin-tlr21-inhibition Low-DM pectin inhibited stimulated TLR2-TLR1 signaling in the tested assays. Condition category: normal nutrient_topic: Pectin research collection; topical membership is not evidence of a direct dietary effect. plain_language: This pectin preparation reduced one receptor-pair signal. organism: Human receptor/cell assays; Mus musculus separately scoped tissue_or_cell_type: Innate immune receptors and intestine experimental_model: Receptor binding, reporter cells, human dendritic cells and mouse ileitis model limitations: Model-specific. Binding and cytokine experiments do not establish prevention of human inflammatory disease. Lack of increased measured SCFAs does not exclude every microbial contribution. exposure: Lemon pectin DM7 versus DM75; cell exposures 1-100 micrograms/mL; mice 3 mg/day before doxorubicin evidence_span: {"source_cache": "artifacts/pectin-research/29545800.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c194f301d46822febd69d3bc9768bd31de73e5dd2ca87f0d3b0e64cd4726dc65", "start_char": 0, "end_char": 1540, "text_sha256": "c194f301d46822febd69d3bc9768bd31de73e5dd2ca87f0d3b0e64cd4726dc65"} [pectin-p29545800] Dietary Fiber Pectin Directly Blocks Toll-Like Receptor 2-1 and Prevents Doxorubicin-Induced Ileitis. (2018). https://pubmed.ncbi.nlm.nih.gov/29545800/ DOI: 10.3389/fimmu.2018.00383

evidence_span

{"source_cache": "artifacts/pectin-research/29545800.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c194f301d46822febd69d3bc9768bd31de73e5dd2ca87f0d3b0e64cd4726dc65", "start_char": 0, "end_char": 1540, "text_sha256": "c194f301d46822febd69d3bc9768bd31de73e5dd2ca87f0d3b0e64cd4726dc65"}

experimental_model

Receptor binding, reporter cells, human dendritic cells and mouse ileitis model

exposure

Lemon pectin DM7 versus DM75; cell exposures 1-100 micrograms/mL; mice 3 mg/day before doxorubicin

limitations

Model-specific. Binding and cytokine experiments do not establish prevention of human inflammatory disease. Lack of increased measured SCFAs does not exclude every microbial contribution.

nutrient_topic

Pectin research collection; topical membership is not evidence of a direct dietary effect. · Pectin, structurally heterogeneous plant polysaccharides

organism

Human receptor/cell assays; Mus musculus separately scoped

plain_language

The effect did not extend to every TLR2 receptor partnership.

primary_references

[pectin-p29545800] Dietary Fiber Pectin Directly Blocks Toll-Like Receptor 2-1 and Prevents Doxorubicin-Induced Ileitis. (2018). https://pubmed.ncbi.nlm.nih.gov/29545800/ DOI: 10.3389/fimmu.2018.00383

tissue_or_cell_type

Innate immune receptors and intestine

Pectin: metabolism, signaling and nutrient connections (2026-09-17) · lines 373–384

AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Receptor binding, reporter cells, human dendritic cells and mouse ileitis model · source_derived_draft · unverified_draft

### pectin-tlr26-null TLR2-TLR6 signaling was not inhibited under the corresponding assay conditions. Condition category: normal nutrient_topic: Pectin research collection; topical membership is not evidence of a direct dietary effect. plain_language: The effect did not extend to every TLR2 receptor partnership. organism: Human receptor/cell assays; Mus musculus separately scoped tissue_or_cell_type: Innate immune receptors and intestine experimental_model: Receptor binding, reporter cells, human dendritic cells and mouse ileitis model limitations: Model-specific. Binding and cytokine experiments do not establish prevention of human inflammatory disease. Lack of increased measured SCFAs does not exclude every microbial contribution. exposure: Lemon pectin DM7 versus DM75; cell exposures 1-100 micrograms/mL; mice 3 mg/day before doxorubicin evidence_span: {"source_cache": "artifacts/pectin-research/29545800.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c194f301d46822febd69d3bc9768bd31de73e5dd2ca87f0d3b0e64cd4726dc65", "start_char": 0, "end_char": 1540, "text_sha256": "c194f301d46822febd69d3bc9768bd31de73e5dd2ca87f0d3b0e64cd4726dc65"} [pectin-p29545800] Dietary Fiber Pectin Directly Blocks Toll-Like Receptor 2-1 and Prevents Doxorubicin-Induced Ileitis. (2018). https://pubmed.ncbi.nlm.nih.gov/29545800/ DOI: 10.3389/fimmu.2018.00383

availability_state

machinery_impairment Imported condition classification; unverified.

evidence_span

{"source_cache": "artifacts/pectin-research/29545800.fulltext.txt", "locator": "Primary full-text span; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4b9e856ec2420c457b98f455ec243b742525b63d9382b69ef087456e0136cb42", "start_char": 37198, "end_char": 38286, "text_sha256": "1e7101498d68b59ef3b4b7d5ad57ce9d4aa25f535bc5000e421099adc8720b19"}

experimental_model

Receptor binding, reporter cells, human dendritic cells and mouse ileitis model

exposure

Lemon pectin DM7 versus DM75; cell exposures 1-100 micrograms/mL; mice 3 mg/day before doxorubicin

limitations

Model-specific. Binding and cytokine experiments do not establish prevention of human inflammatory disease. Lack of increased measured SCFAs does not exclude every microbial contribution.

nutrient_topic

Pectin research collection; topical membership is not evidence of a direct dietary effect. · Pectin, structurally heterogeneous plant polysaccharides

organism

Human receptor/cell assays; Mus musculus separately scoped

plain_language

Changing the receptor charges weakens the measured interaction.

primary_references

[pectin-p29545800] Dietary Fiber Pectin Directly Blocks Toll-Like Receptor 2-1 and Prevents Doxorubicin-Induced Ileitis. (2018). https://pubmed.ncbi.nlm.nih.gov/29545800/ DOI: 10.3389/fimmu.2018.00383

tissue_or_cell_type

Innate immune receptors and intestine

trigger_kind

machinery_impairment Imported condition classification; unverified.

Pectin: metabolism, signaling and nutrient connections (2026-09-17) · lines 412–423

AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Receptor binding, reporter cells, human dendritic cells and mouse ileitis model · source_derived_draft · unverified_draft

### pectin-tlr2-mutant DM7 binding was lower to R315Q/R316Q/R321Q/K347Q TLR2 than to the R321Q/K347Q construct. Condition category: machinery_impairment nutrient_topic: Pectin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Changing the receptor charges weakens the measured interaction. organism: Human receptor/cell assays; Mus musculus separately scoped tissue_or_cell_type: Innate immune receptors and intestine experimental_model: Receptor binding, reporter cells, human dendritic cells and mouse ileitis model limitations: Model-specific. Binding and cytokine experiments do not establish prevention of human inflammatory disease. Lack of increased measured SCFAs does not exclude every microbial contribution. exposure: Lemon pectin DM7 versus DM75; cell exposures 1-100 micrograms/mL; mice 3 mg/day before doxorubicin evidence_span: {"source_cache": "artifacts/pectin-research/29545800.fulltext.txt", "locator": "Primary full-text span; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4b9e856ec2420c457b98f455ec243b742525b63d9382b69ef087456e0136cb42", "start_char": 37198, "end_char": 38286, "text_sha256": "1e7101498d68b59ef3b4b7d5ad57ce9d4aa25f535bc5000e421099adc8720b19"} [pectin-p29545800] Dietary Fiber Pectin Directly Blocks Toll-Like Receptor 2-1 and Prevents Doxorubicin-Induced Ileitis. (2018). https://pubmed.ncbi.nlm.nih.gov/29545800/ DOI: 10.3389/fimmu.2018.00383