{"id":"3612f87f-d9bf-55e8-8dd8-18c704eb7c62","stable_key":"d17caac5-7018-5ca8-9e96-95afeb384bc4:pectin-dc-il10","predicate":"reduces","statement":"DM7 also reduced stimulus-dependent IL-10 release in human dendritic cells.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"55434f6a-d627-5e25-bb91-90879996ba55","mechanism_event_label":"The cell result includes IL-10; it should not be simplified to selective suppression of only harmful signals.","subject":{"id":"d54fb89f-e04d-580a-aff2-a97bdab74c19","slug":"low-dm-lemon-pectin","display_name":"Low-methylesterified lemon pectin, DM7 preparation","entity_type_key":"chemical_species"},"object":{"id":"846fd146-8631-513a-8140-dcddf2742b00","slug":"human-dc-il10-release","display_name":"Human dendritic-cell IL-10 release","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"55434f6a-d627-5e25-bb91-90879996ba55","stable_key":"d17caac5-7018-5ca8-9e96-95afeb384bc4:pectin-dc-il10-event","event_type":"biochemical_relationship","label":"The cell result includes IL-10; it should not be simplified to selective suppression of only harmful signals.","description":"DM7 also reduced stimulus-dependent IL-10 release in human dendritic cells.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d54fb89f-e04d-580a-aff2-a97bdab74c19","slug":"low-dm-lemon-pectin","display_name":"Low-methylesterified lemon pectin, DM7 preparation","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"846fd146-8631-513a-8140-dcddf2742b00","slug":"human-dc-il10-release","display_name":"Human dendritic-cell IL-10 release","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/pectin-research/29545800.fulltext.txt\", \"locator\": \"Primary full-text span; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"4b9e856ec2420c457b98f455ec243b742525b63d9382b69ef087456e0136cb42\", \"start_char\": 38875, \"end_char\": 39612, \"text_sha256\": \"8b75517328dfdbdd5a4290c5523e8136762b0456a8fd69af5e0e172edb168bda\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Receptor binding, reporter cells, human dendritic cells and mouse ileitis model","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Lemon pectin DM7 versus DM75; cell exposures 1-100 micrograms/mL; mice 3 mg/day before doxorubicin","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Model-specific. 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