{"id":"9d7657d3-923f-5a5a-8d52-df122bcaaf73","stable_key":"d17caac5-7018-5ca8-9e96-95afeb384bc4:pectin-mouse-ileitis","predicate":"attenuates","statement":"DM7 reduced inflammatory features in the doxorubicin mouse ileitis model.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"aa8076eb-36f9-5714-8d51-0fcdd3be207e","mechanism_event_label":"The animal experiment found less intestinal inflammation.","subject":{"id":"d54fb89f-e04d-580a-aff2-a97bdab74c19","slug":"low-dm-lemon-pectin","display_name":"Low-methylesterified lemon pectin, DM7 preparation","entity_type_key":"chemical_species"},"object":{"id":"d2d6cfbf-2f9f-5118-8b0d-9249cb4cc80d","slug":"mouse-doxorubicin-ileitis","display_name":"Mouse doxorubicin-induced ileitis","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"aa8076eb-36f9-5714-8d51-0fcdd3be207e","stable_key":"d17caac5-7018-5ca8-9e96-95afeb384bc4:pectin-mouse-ileitis-event","event_type":"biochemical_relationship","label":"The animal experiment found less intestinal inflammation.","description":"DM7 reduced inflammatory features in the doxorubicin mouse ileitis model.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d54fb89f-e04d-580a-aff2-a97bdab74c19","slug":"low-dm-lemon-pectin","display_name":"Low-methylesterified lemon pectin, DM7 preparation","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d2d6cfbf-2f9f-5118-8b0d-9249cb4cc80d","slug":"mouse-doxorubicin-ileitis","display_name":"Mouse doxorubicin-induced ileitis","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/pectin-research/29545800.fulltext.txt\", \"locator\": \"Primary full-text span; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"4b9e856ec2420c457b98f455ec243b742525b63d9382b69ef087456e0136cb42\", \"start_char\": 40658, \"end_char\": 42820, \"text_sha256\": \"8fbd4579844713a0928cb551165880b3ad5d4b1b345b812e096ab830d0a1a0e3\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Receptor binding, reporter cells, human dendritic cells and mouse ileitis model","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Lemon pectin DM7 versus DM75; cell exposures 1-100 micrograms/mL; mice 3 mg/day before doxorubicin","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Model-specific. 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Lack of increased measured SCFAs does not exclude every microbial contribution.\nexposure: Lemon pectin DM7 versus DM75; cell exposures 1-100 micrograms/mL; mice 3 mg/day before doxorubicin\nevidence_span: {\"source_cache\": \"artifacts/pectin-research/29545800.fulltext.txt\", \"locator\": \"Primary full-text span; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"4b9e856ec2420c457b98f455ec243b742525b63d9382b69ef087456e0136cb42\", \"start_char\": 40658, \"end_char\": 42820, \"text_sha256\": \"8fbd4579844713a0928cb551165880b3ad5d4b1b345b812e096ab830d0a1a0e3\"}\n[pectin-p29545800] Dietary Fiber Pectin Directly Blocks Toll-Like Receptor 2-1 and Prevents Doxorubicin-Induced Ileitis. 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