Component

Diallyl trisulfide / DATS

Diallyl trisulfide / DATS. Interpret through the linked study species, preparation, exposure and measured endpoint.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. DATS reacted rapidly with GSH to release sulfide through the reported exchange and perthiol-reduction chemistry.

    Diallyl trisulfide / DATS → Sulfide generation in the DATS plus GSH chemical assay Recorded from sourceungraded
    Experimental context and source evidence
    evidence_access
    Primary indexed abstract reviewed; full methods, exact concentrations or species-specific attribution remain unextracted unless explicitly stated in the abstract or separately verified publisher text.
    experimental_model
    Purified-compound chemical study; abstract-level access.
    interpretation_status
    Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
    limitations
    DATS-specific; no automatic transfer to allicin, DADS, aged extract, or human blood-pressure response.
    plain_language
    DATS reacted rapidly with GSH to release sulfide through the reported exchange and perthiol-reduction chemistry.
    primary_references
    Diallyl Trisulfide Is a Fast H2S Donor, but Diallyl Disulfide Is a Slow One: The Reaction Pathways and Intermediates of Glutathione with Polysulfides. | 2015 | DOI 10.1021/acs.orglett.5b01962 | PMID 26301500 | https://pubmed.ncbi.nlm.nih.gov/26301500/ | https://doi.org/10.1021/acs.orglett.5b01962
    source_locator
    Reviewed reference lines 83-83; exact primary location described in quoted passage where extracted.

    Allicin: detailed mechanisms of action (reviewed 5 October 2026) · lines 83–83

    Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Purified-compound chemical study; abstract-level access. · Recorded from source · Recorded from source

    **DATS and DADS differ.** A later chemical study found rapid GSH-dependent sulfide release from DATS, involving an allyl-perthiol intermediate, but very little and slow release from DADS. DATS contamination could account for fast release attributed to DADS. Sulfur-chain length, purity, and reaction conditions belong in the record. This qualifies older attribution without deleting either observation; it does not establish that allicin or aged garlic extract has the same behavior. [Liang 2015](https://pubmed.ncbi.nlm.nih.gov/26301500/)
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Purified DADS released only a small amount of sulfide slowly with GSH; DATS impurity can explain apparent rapid DADS release.

    Diallyl disulfide / DADS → Sulfide generation in the DADS plus GSH chemical assay Recorded from sourceungraded
    Experimental context and source evidence
    evidence_access
    Primary indexed abstract reviewed; full methods, exact concentrations or species-specific attribution remain unextracted unless explicitly stated in the abstract or separately verified publisher text.
    experimental_model
    Purified-compound comparison; source-specific purity interpretation.
    interpretation_status
    Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
    limitations
    Slow/minute is not zero. Historical observations remain preserved with purity qualification, not erased as fictional experiments.
    plain_language
    Purified DADS released only a small amount of sulfide slowly with GSH; DATS impurity can explain apparent rapid DADS release.
    primary_references
    Diallyl Trisulfide Is a Fast H2S Donor, but Diallyl Disulfide Is a Slow One: The Reaction Pathways and Intermediates of Glutathione with Polysulfides. | 2015 | DOI 10.1021/acs.orglett.5b01962 | PMID 26301500 | https://pubmed.ncbi.nlm.nih.gov/26301500/ | https://doi.org/10.1021/acs.orglett.5b01962
    source_locator
    Reviewed reference lines 83-83; exact primary location described in quoted passage where extracted.

    Allicin: detailed mechanisms of action (reviewed 5 October 2026) · lines 83–83

    Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Purified-compound comparison; source-specific purity interpretation. · Recorded from source · Recorded from source

    **DATS and DADS differ.** A later chemical study found rapid GSH-dependent sulfide release from DATS, involving an allyl-perthiol intermediate, but very little and slow release from DADS. DATS contamination could account for fast release attributed to DADS. Sulfur-chain length, purity, and reaction conditions belong in the record. This qualifies older attribution without deleting either observation; it does not establish that allicin or aged garlic extract has the same behavior. [Liang 2015](https://pubmed.ncbi.nlm.nih.gov/26301500/)
    Complete structured claim and evidence

  2. Omission of added GSH did not significantly alter the tested polysulfide-induced rat aortic relaxation.

    GSH → Rat aortic-ring relaxation in the garlic-polysulfide study Recorded from sourceungraded
    Experimental context and source evidence
    evidence_access
    Primary full text available; selected claim-relevant methods, results, tables/figures and limitations reviewed. Supplemental proteome and all secondary findings are not exhaustively extracted.
    experimental_condition
    Same tested polysulfide with added GSH one tested donor · Diallyl trisulfide / DATS Condition belongs to the full experimental contrast; do not separate a joint intervention.
    experimental_condition
    Same tested polysulfide with added GSH no exogenous addition · GSH Condition belongs to the full experimental contrast; do not separate a joint intervention.
    experimental_contrast
    {"intervention": "Polysulfide exposure without added GSH", "comparator": "Same tested polysulfide with added GSH", "endpoint": "Omission of added GSH did not significantly alter the tested polysulfide-induced rat aortic relaxation.", "effect_direction": "no_detected_change", "combination": "joint", "conditions": [{"entity_slug": "glutathione", "state": "no exogenous addition"}, {"entity_slug": "diallyl-trisulfide", "state": "one tested donor"}]} Explicit extracted experimental comparison; source-derived draft.
    experimental_model
    Rat aortic rings; Figure 3E, DATS/DPDS comparisons with and without 1 mM added GSH.
    interpretation_status
    Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
    limitations
    Omitting added GSH does not remove endogenous vascular thiols. Null is relaxation, not sulfide generation; no clinical glutathione gate.
    plain_language
    Omission of added GSH did not significantly alter the tested polysulfide-induced rat aortic relaxation.
    primary_references
    Hydrogen sulfide mediates the vasoactivity of garlic. | 2007 | DOI 10.1073/pnas.0705710104 | PMID 17951430 | https://pubmed.ncbi.nlm.nih.gov/17951430/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC2084282/ | https://doi.org/10.1073/pnas.0705710104
    source_locator
    Reviewed reference lines 81-81; exact primary location described in quoted passage where extracted.

    Allicin: detailed mechanisms of action (reviewed 5 October 2026) · lines 81–81

    Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Rat aortic rings; Figure 3E, DATS/DPDS comparisons with and without 1 mM added GSH. · Recorded from source · Recorded from source

    **Alternative thiols and the vascular null.** GSH, cysteine, homocysteine, and NAC each supported garlic-associated sulfide generation in cell-free assays. In rat aortic rings, added GSH aided detectable sulfide production, but its omission did not significantly alter the tested polysulfide-induced relaxation. Membrane and intracellular thiols therefore matter alongside the added reagent. NAC is a direct participant in this chemistry, not a selective way to raise cellular GSH. Results in deoxygenated red-cell assays and oxygen-controlled rat vessels are not human oral pharmacokinetics. [Benavides 2007](https://pmc.ncbi.nlm.nih.gov/articles/PMC2084282/)
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.