Component
Rat aortic-ring relaxation in the garlic-polysulfide study
Rat aortic-ring relaxation in the garlic-polysulfide study. Interpret through the linked study species, preparation, exposure and measured endpoint.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Omission of added GSH did not significantly alter the tested polysulfide-induced rat aortic relaxation.
Experimental context and source evidence
- evidence_access
- Primary full text available; selected claim-relevant methods, results, tables/figures and limitations reviewed. Supplemental proteome and all secondary findings are not exhaustively extracted.
- experimental_condition
- Same tested polysulfide with added GSH one tested donor · Diallyl trisulfide / DATS Condition belongs to the full experimental contrast; do not separate a joint intervention.
- experimental_condition
- Same tested polysulfide with added GSH no exogenous addition · GSH Condition belongs to the full experimental contrast; do not separate a joint intervention.
- experimental_contrast
- {"intervention": "Polysulfide exposure without added GSH", "comparator": "Same tested polysulfide with added GSH", "endpoint": "Omission of added GSH did not significantly alter the tested polysulfide-induced rat aortic relaxation.", "effect_direction": "no_detected_change", "combination": "joint", "conditions": [{"entity_slug": "glutathione", "state": "no exogenous addition"}, {"entity_slug": "diallyl-trisulfide", "state": "one tested donor"}]} Explicit extracted experimental comparison; source-derived draft.
- experimental_model
- Rat aortic rings; Figure 3E, DATS/DPDS comparisons with and without 1 mM added GSH.
- interpretation_status
- Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
- limitations
- Omitting added GSH does not remove endogenous vascular thiols. Null is relaxation, not sulfide generation; no clinical glutathione gate.
- plain_language
- Omission of added GSH did not significantly alter the tested polysulfide-induced rat aortic relaxation.
- primary_references
- Hydrogen sulfide mediates the vasoactivity of garlic. | 2007 | DOI 10.1073/pnas.0705710104 | PMID 17951430 | https://pubmed.ncbi.nlm.nih.gov/17951430/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC2084282/ | https://doi.org/10.1073/pnas.0705710104
- source_locator
- Reviewed reference lines 81-81; exact primary location described in quoted passage where extracted.
Allicin: detailed mechanisms of action (reviewed 5 October 2026) · lines 81–81
Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Rat aortic rings; Figure 3E, DATS/DPDS comparisons with and without 1 mM added GSH. · Recorded from source · Recorded from source
**Alternative thiols and the vascular null.** GSH, cysteine, homocysteine, and NAC each supported garlic-associated sulfide generation in cell-free assays. In rat aortic rings, added GSH aided detectable sulfide production, but its omission did not significantly alter the tested polysulfide-induced relaxation. Membrane and intracellular thiols therefore matter alongside the added reagent. NAC is a direct participant in this chemistry, not a selective way to raise cellular GSH. Results in deoxygenated red-cell assays and oxygen-controlled rat vessels are not human oral pharmacokinetics. [Benavides 2007](https://pmc.ncbi.nlm.nih.gov/articles/PMC2084282/)
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.