Component

Creatinine

Independently recorded entity or measured process. Linked claims specify compartment, assay and experimental scope.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Creatinine excretion represents continuing loss from the creatine/phosphocreatine pool, which is replaced by diet and/or endogenous synthesis.

    Creatinine → Creatine source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/creatine-research/19017728.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8394bd0e01991356b47a2e57593a5054e565b4020d50226b1331dbb290fc0cee", "start_char": 0, "end_char": 1599, "text_sha256": "8394bd0e01991356b47a2e57593a5054e565b4020d50226b1331dbb290fc0cee"}
    experimental_model
    Rat feeding, isolated hepatocytes and in-vivo hepatic balance
    exposure
    Creatine-fed versus creatine-free conditions; guanidinoacetate and methionine substrate experiments
    limitations
    Biochemical premise of the rat synthesis paper, not a new quantitative human turnover measurement or a direct measure of tissue stores.
    nutrient_topic
    Creatine research collection; topical membership is not evidence of a direct dietary effect. · Creatine
    organism
    Rats
    plain_language
    The pool needs replenishment because some material continually leaves as creatinine.
    primary_references
    [creatine-p19017728] Creatine synthesis: hepatic metabolism of guanidinoacetate and creatine in the rat in vitro and in vivo. (2009). https://pubmed.ncbi.nlm.nih.gov/19017728/ DOI: 10.1152/ajpendo.90547.2008
    tissue_or_cell_type
    Kidney, liver, plasma and isolated hepatocytes

    Creatine: synthesis, transport, phosphocreatine energetics and nutrient interactions (2026-09-17) · lines 256–267

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Rat feeding, isolated hepatocytes and in-vivo hepatic balance · source_derived_draft · unverified_draft

    ### creatine-creatinine-loss Creatinine excretion represents continuing loss from the creatine/phosphocreatine pool, which is replaced by diet and/or endogenous synthesis. Condition category: normal nutrient_topic: Creatine research collection; topical membership is not evidence of a direct dietary effect. plain_language: The pool needs replenishment because some material continually leaves as creatinine. organism: Rats tissue_or_cell_type: Kidney, liver, plasma and isolated hepatocytes experimental_model: Rat feeding, isolated hepatocytes and in-vivo hepatic balance limitations: Biochemical premise of the rat synthesis paper, not a new quantitative human turnover measurement or a direct measure of tissue stores. exposure: Creatine-fed versus creatine-free conditions; guanidinoacetate and methionine substrate experiments evidence_span: {"source_cache": "artifacts/creatine-research/19017728.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8394bd0e01991356b47a2e57593a5054e565b4020d50226b1331dbb290fc0cee", "start_char": 0, "end_char": 1599, "text_sha256": "8394bd0e01991356b47a2e57593a5054e565b4020d50226b1331dbb290fc0cee"} [creatine-p19017728] Creatine synthesis: hepatic metabolism of guanidinoacetate and creatine in the rat in vitro and in vivo. (2009). https://pubmed.ncbi.nlm.nih.gov/19017728/ DOI: 10.1152/ajpendo.90547.2008
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Plasma creatine decreased 40% in both meal states; creatinine fell 9% and dimethylglycine 16% postprandially.

    Vitamin B6 → Creatine source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    cross_nutrient
    Plasma metabolites connect B6 status with one-carbon metabolism without establishing a complete causal chain.
    experimental_model
    Twenty-three healthy adults; paired pre/postprandial LC-MS/MS metabolite profiling.
    exposure
    28 days below 0.35 mg/day B6. Related restriction research program; do not count paper totals as independent trial replications.
    limitations
    This does not establish exhausted SAM, impaired muscle phosphocreatine or a direct PLP requirement for creatine methylation.
    nutrient_topic
    Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin B6
    organism
    Homo sapiens
    plain_language
    B6 restriction changed selected methylation-related metabolites.
    primary_references
    [b6-dasilva2013] Metabolite profile analysis reveals functional effects of 28-day vitamin B-6 restriction on one-carbon metabolism and tryptophan catabolic pathways in healthy men and women (2013). https://pubmed.ncbi.nlm.nih.gov/23966327/ DOI: 10.3945/jn.113.180588
    tissue_or_cell_type
    Human blood and whole-body measurements
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Vitamin B6: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1423–1434

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Twenty-three healthy adults; paired pre/postprandial LC-MS/MS metabolite profiling. · source_derived_draft · unverified_draft

    ### b6-restriction-creatine-profile Plasma creatine decreased 40% in both meal states; creatinine fell 9% and dimethylglycine 16% postprandially. Condition category: nutrient_deficiency nutrient_topic: Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. plain_language: B6 restriction changed selected methylation-related metabolites. organism: Homo sapiens tissue_or_cell_type: Human blood and whole-body measurements experimental_model: Twenty-three healthy adults; paired pre/postprandial LC-MS/MS metabolite profiling. limitations: This does not establish exhausted SAM, impaired muscle phosphocreatine or a direct PLP requirement for creatine methylation. exposure: 28 days below 0.35 mg/day B6. Related restriction research program; do not count paper totals as independent trial replications. cross_nutrient: Plasma metabolites connect B6 status with one-carbon metabolism without establishing a complete causal chain. [b6-dasilva2013] Metabolite profile analysis reveals functional effects of 28-day vitamin B-6 restriction on one-carbon metabolism and tryptophan catabolic pathways in healthy men and women (2013). https://pubmed.ncbi.nlm.nih.gov/23966327/ DOI: 10.3945/jn.113.180588
    Complete structured claim and evidence

  2. Serum creatinine was higher with creatine ethyl ester than with monohydrate or placebo at the measured post-baseline visits.

    Creatine ethyl ester → Serum creatinine concentration source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    biomarker_context Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/creatine-research/19228401.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "381c3f18fe14f7eba6ee3abe9ca81ab4f02c293c3dd4593ea27dcbb6f879a114", "start_char": 0, "end_char": 1727, "text_sha256": "381c3f18fe14f7eba6ee3abe9ca81ab4f02c293c3dd4593ea27dcbb6f879a114"}
    experimental_model
    Seven-week randomized double-blind comparison plus resistance training
    exposure
    Creatine ethyl ester, creatine monohydrate or placebo with loading and maintenance
    limitations
    The abstract conclusion overstates some comparisons: reported muscle total creatine did not differ significantly between formulations. This curation preserves the actual reported outcomes.
    nutrient_topic
    Creatine research collection; topical membership is not evidence of a direct dietary effect. · Creatine
    organism
    30 previously non-resistance-trained men
    plain_language
    A formulation can change the creatinine marker; this trial alone does not establish the mechanism or diagnose kidney injury.
    primary_references
    [creatine-p19228401] The effects of creatine ethyl ester supplementation combined with heavy resistance training on body composition, muscle performance, and serum and muscle creatine levels. (2009). https://pubmed.ncbi.nlm.nih.gov/19228401/ DOI: 10.1186/1550-2783-6-6
    tissue_or_cell_type
    Serum and muscle metabolites, body composition and performance
    trigger_kind
    biomarker_context Imported condition classification; unverified.

    Creatine: synthesis, transport, phosphocreatine energetics and nutrient interactions (2026-09-17) · lines 1101–1112

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Seven-week randomized double-blind comparison plus resistance training · source_derived_draft · unverified_draft

    ### creatine-ethyl-ester-creatinine Serum creatinine was higher with creatine ethyl ester than with monohydrate or placebo at the measured post-baseline visits. Condition category: biomarker_context nutrient_topic: Creatine research collection; topical membership is not evidence of a direct dietary effect. plain_language: A formulation can change the creatinine marker; this trial alone does not establish the mechanism or diagnose kidney injury. organism: 30 previously non-resistance-trained men tissue_or_cell_type: Serum and muscle metabolites, body composition and performance experimental_model: Seven-week randomized double-blind comparison plus resistance training limitations: The abstract conclusion overstates some comparisons: reported muscle total creatine did not differ significantly between formulations. This curation preserves the actual reported outcomes. exposure: Creatine ethyl ester, creatine monohydrate or placebo with loading and maintenance evidence_span: {"source_cache": "artifacts/creatine-research/19228401.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "381c3f18fe14f7eba6ee3abe9ca81ab4f02c293c3dd4593ea27dcbb6f879a114", "start_char": 0, "end_char": 1727, "text_sha256": "381c3f18fe14f7eba6ee3abe9ca81ab4f02c293c3dd4593ea27dcbb6f879a114"} [creatine-p19228401] The effects of creatine ethyl ester supplementation combined with heavy resistance training on body composition, muscle performance, and serum and muscle creatine levels. (2009). https://pubmed.ncbi.nlm.nih.gov/19228401/ DOI: 10.1186/1550-2783-6-6
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards